Serotonin 5-HT1B receptors mediate the antidepressant- and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation in a mouse model of social defeat

Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway

“…Based on clinical observation, both males and females are affected by the MDD, and their unique physiological and psychological differences may impact disease progression and treatment outcomes ( Brody et al, 2018 ; Cosgrove et al, 2007 ; Khan et al, 2005 ; Kornstein et al, 2000 ; Mocny-Pachońska et al, 2020 ; Verma et al, 2011 ). Consistent with clinical observation, male and female chronic social stress mouse models demonstrated different behavioral performance ( Furman et al, 2022 ) and treatment effect ( Silk et al, 2022 ). In order to minimize the effect caused by sexual issues and simplify the experimental variable, the use of exclusively male mice was applied in this study though it would restrict the generalizability of the findings to clinical applications.…”

Reduction of aggressive behaviour following hypothalamic deep brain stimulation: involvement of 5-HT1Aand testosterone

“…Stereotaxic surgeries were performed for electrode implant and control surgery, as previously reported [51,52]. Under Isoflurane anesthesia and analgesia (Meloxicam, 5mg/Kg, SC), one stainless steel electrode (0.5 mm lead exposure, Plastics One model 333/3) was implanted, targeting the posterior hypothalamic nucleus in the right hemisphere (ML: 0.2; AP: -2.4; DV: -4.3) [53] and 2 stainless-steel ground/anchoring screws over the parietal cortex.…”