Serotonin (5-hydroxytryptamine, 5-HT) enhances migration of rat aortic smooth muscle cells through 5-HT2 receptors

Tamura, Ken; Kanzaki, Tetsuto; Saitō, Yasushi; Otabe, Masako; Morisaki, Naho

doi:10.1016/s0021-9150(97)00077-4

Cited by 43 publications

(18 citation statements)

References 17 publications

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“…A developmental role of 5-HT has been described previously in non-neural tissues as diverse as the palate and craniofacial mesenchyme (Zimmerman et al, 1983;Shuey et al, 1992;Moiseiwitch and Lauder, 1995), the heart (Yavarone et al, 1993;Choi et al, 1997), and the endothelium and vascular smooth muscle (Bottaro et al, 1985;Bell and Madri, 1989;Tamura et al, 1997). cell migration, typically mediated by 5-HT 2 receptor subtypes, has been reliably documented in all these instances (Zimmerman et al, 1983;Bottaro et al, 1985;Bell and Madri, 1989;Shuey et al, 1992;Yavarone et al, 1993;Moiseiwitch and Lauder, 1995;Choi et al, 1997;Tamura et al, 1997).…”

Section: Possible Mechanisms Of Serotonin-induced Alterations In 5-htmentioning

confidence: 79%

“…cell migration, typically mediated by 5-HT 2 receptor subtypes, has been reliably documented in all these instances (Zimmerman et al, 1983;Bottaro et al, 1985;Bell and Madri, 1989;Shuey et al, 1992;Yavarone et al, 1993;Moiseiwitch and Lauder, 1995;Choi et al, 1997;Tamura et al, 1997). The involvement of 5-HT in regulating cell migration may be more widespread than anticipated, given the broad distribution of transient 5-HTT immunoreactivity recently described in mouse embryos (Hansson et al, 1999).…”

Section: Possible Mechanisms Of Serotonin-induced Alterations In 5-htmentioning

confidence: 95%

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Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release

et al. 2001

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Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2). 5-HTT knock-out (ko) mice reveal a nearly complete absence of 5-HT in the cerebral cortex by immunohistochemistry, and of barrels, both at P7 and adulthood. Quantitative electron microscopy reveals that 5-HTT ko affects neither the density of synapses nor the length of synaptic contacts in layer IV. VMAT2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-HT, also show a complete lack of 5-HT in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth. Transient 5-HTT expression is thus required for barrel pattern formation, whereas activity-dependent vesicular 5-HT release is not.

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Section: Possible Mechanisms Of Serotonin-induced Alterations In 5-htmentioning

confidence: 79%

Section: Possible Mechanisms Of Serotonin-induced Alterations In 5-htmentioning

confidence: 95%

Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release

et al. 2001

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“…1 When platelets adhere and aggregate at a site of vessel injury, 5-HT is secreted and directly accelerates platelet aggregation and potentiates the response of platelets to other agonists such as adenosine diphosphate, collagen, and thromboxane A 2 . 2 5-HT also promotes the proliferation, [3][4][5] migration, 6 and contraction [7][8][9] of vascular smooth muscle cells (VSMCs). In addition to physiologic hemostasis, these vascular responses play a pivotal role in the development and progression of thrombotic diseases.…”

Section: Introductionmentioning

confidence: 99%

Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells

Kawano

Tsuji

Nishimura

et al. 2001

Blood

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“…In state of vascular injury, subsequent platelet activation accompanied by endothelial damage provides increasing local plasma level of 5-HT. Furthermore, 5-HT causes the proliferation, contraction, and migration of VSMCs through the 5-HT2A receptor ampliied by various intracellular signaling pathways [37][38][39]. Thus, 5-HT plays the basic principle of vascular repair, which spreads to neointimal thickening and decrease of peripheral blood low.…”

Section: Serotonin -A Chemical Messenger Between All Types Of Living mentioning

confidence: 99%

Serotonin Effects on Expression of the LDL Receptor Family Member LR11 and 7-Ketocholesterol–Induced Apoptosis in Human Vascular Smooth Muscle Cells

Nagayama¹,

Tatsuno²

2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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We previously conirmed the efect of sarpogrelate hydrochloride (sarpogrelate), 5-hydroxytryptamine (5-HT) 2A receptor antagonist on cardio-ankle vascular index (CAVI) as a marker of systemic arterial stifness. After 6 months of treatment with sarpogrelate for 35 type 2 diabetic patients, decreased CAVI, indicating the ameliorated arterial stifness, was observed. Therefore, via 5-HT2A receptor blockade, sarpogrelate might efect as a vasoactive agent, as well as an inhibitor of platelet aggregation. 5-HT is a known mitogen for vascular smooth muscle cells (VSMCs). In addition, the pathogenic change of VSMCs such as dediferentiation and proliferation/apoptosis represents one of the atherosclerotic changes. On the other hand, LR11, a mosaic LDL receptor family member, may involve in the invasion of VSMCs into neointimal thickening. We therefore investigated an in vitro study to clarify whether 5-HT was concerned to LR11 expression and apoptosis of human VSMCs induced by 7-ketocholesterol (7KCHO), a major oxidation product of cholesterol involved in plaque destabilization. Resultantly, 5-HT accelerated the proliferation of VSMCs, and this efect was suppressed by simultaneous addition of sarpogrelate. Sarpogrelate also atenuated the 5-HT-induced LR11 mRNA expression in VSMCs. Additionally, 5-HT atenuated the 7KCHO-induced apoptosis of VSMCs through caspase-dependent pathway. These results suggest new knowledge on the modiication of human VSMCs induced by 5-HT.

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Serotonin (5-hydroxytryptamine, 5-HT) enhances migration of rat aortic smooth muscle cells through 5-HT2 receptors

Cited by 43 publications

References 17 publications

Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release

Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release

Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells

Serotonin Effects on Expression of the LDL Receptor Family Member LR11 and 7-Ketocholesterol–Induced Apoptosis in Human Vascular Smooth Muscle Cells

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