Serotonin: a review

Mohammadzadeh, Leila; Moses, Lisa L; Gwaltney‐Brant, Sharon M.

doi:10.1111/j.1365-2885.2008.00944.x

Cited by 406 publications

(317 citation statements)

References 91 publications

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“…Diversos estudos têm mostrado sua participação na modulação da motilidade gastrointestinal, tônus vascular periférico, tônus vascular cerebral, além de exercer importante função plaquetária e na fisiopatologia de diversas desordens de humor, vômito, enxaquecas, SII e hipertensão sistêmica e pulmonar (MOHAMMAD-ZADEH; MOSES; GWALTNEY--BRANT, 2008).…”

Section: Desenvolvimento Serotoninaunclassified

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O Eixo Intestino-Cérebro E O Papel Da Serotonina

Vedovato¹,

Trevizan²,

Zucoloto³

et al. 2015

Arq. Ciênc. Saúde Unipar

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VEDOVATO, K.; TREVIZAN, A. R.; ZUCOLOTO, C. N.; BERNARDI, M. D. L.; ZANONI, J. N.; MARTINS, J. V. C. P. O eixo intestinocérebro e o papel da serotonina. Arq. Ciênc. Saúde Unipar, Umuarama, v. 18 n. 1, p. 33-42, jan./abr. 2014 RESUMO: Este trabalho teve por finalidade buscar informações na literatura que descrevam a interação entre o sistema nervoso central (SNC) e sistema nervoso entérico (SNE), e que demonstrem de que forma a serotonina pode atuar no "eixo intestino-cérebro". A serotonina (5-hidroxitriptamina, 5-HT) originalmente descoberta em 1937 por Vittorio Erspamer é uma indolamina, encontrada em células do trato gastrointestinal, plaquetas e no sistema nervoso central de mamíferos, sendo que cerca de 95% da 5-HT corpórea é produzida no intestino. De acordo com a literatura o trato gastrointestinal é inervado por cinco diferentes classes de neurônios: neurônios entéricos, aferentes vagal, aferentes da coluna vertebral, eferentes parassimpáticos e eferentes simpáticos. Os alvos primários da 5-HT que é secretado pelas células enteroendócrinas são as projeções intrínsecas constituída por neurônios aferentes primários da mucosa e plexo mientérico, e projeções extrínsecas, constituída por nervos que transmitem sensações gerais além de náuseas e desconforto para o sistema nervoso central. Após os dados compilados da literatura fica claro que o SNE desempenha papel singular, podendo agir de maneira independente, mas também mantém sinapses com o SNC, por meio do nervo vago. Dessa forma, ambos os sistemas podem influenciar a atividade um do outro mediante o "eixo intestino-cérebro". Adicionalmente a 5-HT apresenta-se como um importante neurotransmissor envolvido na interação entre o SNE o SNC, importante na regulação da sensação de motilidade e secreção intestinal e também atua na ativação e condução da informação ao SNC. PALAVRAS-CHAVE: Sistema nervoso entérico; Sistema nervoso central; Intestino; Serotonina. THE BRAIN-INTESTINE AXIS AND THE ROLE OF SEROTONINABSTRACT: This paper aims to seek literature information describing the interaction between the central and enteric nervous system, and to demonstrate how serotonin may be acting on the "brain-intestine axis." Serotonin, originally discovered in 1937 by Vittorio Erspamer, is an indoleamine found in cells in the gastrointestinal tract, platelets and in the central nervous system of mammals, with approximately 95% of body 5-HT produced in the intestine. According to literature, the gastrointestinal tract is innervated by five different neuron classes: enteric neurons, vagal afferent, spinal afferent, parasympathetic efferent, and sympathetic efferent. The primary targets of serotonin secreted by entero-endocrine cells are the intrinsic projections composed by primary afferent neurons of the mucosa and myenteric plexus, and extrinsic projections, consisting of nerves that send general sensations as well as nausea and general discomfort to the central nervous system. After the data were compiled from the literature, it is clear that the enteric nervous system p...

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Section: Desenvolvimento Serotoninaunclassified

“…Além de atuar sobre a modulação da motilidade gastrintestinal e função plaquetá-ria, a serotonina (5-HT) participa efetivamente da regulação hidroeletrolítica, modulando a sede e o apetite, ingestão alimentar, balanço energético, regulação da emoção e processos do controle comportamental (MOHAMMAD-ZADEH; MO-SES; GWALTNEY-BRANT, 2008).…”

Section: Introductionunclassified

O Eixo Intestino-Cérebro E O Papel Da Serotonina

Vedovato¹,

Trevizan²,

Zucoloto³

et al. 2015

Arq. Ciênc. Saúde Unipar

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“…More important, activated platelets liberate serotonin and thromboxane A 2 , both of which are potent vasoactive compounds implicated in several clinical situations, such as angina, acute coronary syndrome, and vasospasm 10, 11, 12. Serotonin and thromboxane A 2 function through their cell surface receptors (serotonin 2A+2B and thromboxane A 2 receptors), coupled to both the G q/11 and G 12/13 families of G‐protein–coupled receptors, respectively.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms Responsible for Serotonin Vascular Reactivity Sex Differences in the Internal Mammary Artery

Lamin

Jaghoori

Jakobczak

et al. 2018

JAHA

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BackgroundThe increased adverse cardiac events in women undergoing coronary artery bypass grafting are multifactorial and may include clinical, psychosocial, and biological factors. Potential contributing biological factors could include vascular hyperreactivity of the internal mammary artery (IMA) to endogenous vasoconstrictors in women, resulting in a predilection to myocardial ischemia. This study evaluated sex differences in serotonin and thromboxane A2 dependent vasoconstriction in human isolated IMA, with the mechanistic role of (1) the endothelium, (2) nitric oxide (NO), (3) prostaglandins, and (4) receptor activity investigated for any observed sex difference.Methods and ResultsViable isolated human IMA segments were obtained from 116 patients (44 women [mean age, 66.8±12.2 years] and 72 men [mean age, 66.6±10.4 years]) undergoing coronary artery bypass grafting. Cumulative concentration‐response curves for serotonin and thromboxane A2 mimetic, U46619, were determined and revealed an increased sensitivity to serotonin but not U46619 in women. This sex difference to serotonin was further assessed by the following: (1) endothelial denudation, (2) endothelial NO synthase inhibition and NO quantification using electron paramagnetic resonance, (3) cyclooxygenase inhibition and prostaglandin metabolite quantification using mass spectrometry, and (4) quantification of receptor activity status. The female hyperreactivity to serotonin was (1) abolished by endothelial denudation; (2) unaffected by NO synthase inhibition, with no difference in electron paramagnetic resonance–assessed NO levels; (3) abolished by cyclooxygenase inhibition (quantification of prostaglandins in IMA revealed a trend towards reduced 6‐keto prostaglandin F1α in female IMA; P=0.08); and (4) unrelated to receptor activity.ConclusionsThese data indicate that female IMAs are hyperreactive to serotonin but not U46619, with the former attributable to an endothelium‐dependent cyclooxygenase pathway.

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“…As most families exhibit heterogeneity in form and function, they are further divided in subtypes as 5-HT 1A and 5-HT 1b , etc. The EC cells of the intestine are the main source of peripheral serotonin (Mohammad-Zadeh et al 2008). As SI-NETs originated from these EC cells, serotonin immunohistochemistry (IHC) is positive in >85% of the SI-NETs and can be used as a marker for intestinal origin of neuroendocrine tumours (Yang et al 1983, Krishnamurthy & Dayal 1997, Facco et al 1998, Niederle et al 2016.…”

Section: Serotoninmentioning

confidence: 99%

Small intestinal neuroendocrine tumours and fibrosis: an entangled conundrum

Blažević¹,

Hofland²,

Hofland³

et al. 2018

Endocrine-Related Cancer

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Small intestinal neuroendocrine tumours (SI-NETs) are neoplasms characterized by their ability to secrete biogenic amines and peptides. These cause distinct clinical pathology including carcinoid syndrome, marked by diarrhoea and flushing, as well as fibrosis, notably mesenteric fibrosis. Mesenteric fibrosis often results in significant morbidity by causing intestinal obstruction, oedema and ischaemia. Although advancements have been made to alleviate symptoms of carcinoid syndrome and prolong the survival of patients with SI-NETs, therapeutic options for patients with mesenteric fibrosis are still limited. As improved insight in the complex pathogenesis of mesenteric fibrosis is key to the development of new therapies, we evaluated the literature for known and putative mediators of fibrosis in SI-NETs. In this review, we discuss the tumour microenvironment, growth factors and signalling pathways involved in the complex process of fibrosis development and tumour progression in SI-NETs, in order to elucidate potential new avenues for scientific research and therapies to improve the management of patients suffering from the complications of mesenteric fibrosis.

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Serotonin: a review

Cited by 406 publications

References 91 publications

O Eixo Intestino-Cérebro E O Papel Da Serotonina

O Eixo Intestino-Cérebro E O Papel Da Serotonina

Mechanisms Responsible for Serotonin Vascular Reactivity Sex Differences in the Internal Mammary Artery

Small intestinal neuroendocrine tumours and fibrosis: an entangled conundrum

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