Serotonin and central nervous system syndromes of childhood: A review

Coleman, Mary

doi:10.1007/bf01537552

Cited by 39 publications

(5 citation statements)

References 21 publications

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“…Anomalies of amine metabolism have been implicated in some behavioral disorders of childhood. Alterations in serotonin metabolism and blood levels were found in certain retarded, schizophrenic and autistic children (Boullin et al, 1970;Coleman, 1973; P age, 1968\Partington et al, 1973Ritvo et al, 1970;Schain and Freedman, 1961;Campbell et al, 1974Campbell et al, , 1975. Others have found abnormalities in catecholamine metabolism in autistic and atypical children (Cohen et al, 1975).…”

mentioning

confidence: 99%

Blood Platelet Monoamine Oxidase Activity in Schizophrenic Children and Their Families

Campbell¹,

Friedman²,

Green³

et al. 1976

Neuropsychobiology

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In this study monoamine oxidase (MAO) activity was measured in blood platelets of 21 individuals (age 2⁶/₁₂^–19 years) who were diagnosed at preschool age as schizophrenics; MAO activity was not significantly different from that found in normals. An insignificant correlation was found between MAO activity in patients and age; a similar correlation for normals was also insignificant. In a sample of 15 families, no significant correlation between MAO activity of patients and their parents was obtained.

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mentioning

confidence: 99%

Blood Platelet Monoamine Oxidase Activity in Schizophrenic Children and Their Families

Campbell¹,

Friedman²,

Green³

et al. 1976

Neuropsychobiology

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“…It is worth noting that CB1 receptors' activation was also demonstrated to lead to the formation of heterodimers with 5-hydroxy-tryptamine (5-HT)2A receptors, further accounting for the negative cognitive effects of THC, because of their expression and functioning in brain regions specifically being involved in memory impairment [52]. Considering the long-lasting evidence of 5-HT [53] and cognitive [54] abnormalities across the autism-psychosis spectrum, whether they are modulated by the eCB system requires further investigation. Detrimental methylation effects of THC/ cannabis exposure on autism-and neurodevelopment-associated genes controlling social behavior, vocalization behavior, and learning were found in both humans and animals [28,29].…”

Section: Discussionmentioning

confidence: 99%

The Autism–Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System

Colizzi

Bortoletto

Costa³

et al. 2022

IJERPH

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Evidence indicates shared physiopathological mechanisms between autism and psychosis. In this regard, the endocannabinoid system has been suggested to modulate neural circuits during the early stage of neurodevelopment, with implications for both autism and psychosis. Nevertheless, such potential common markers of disease have been investigated in both autism and psychosis spectrum disorders, without considering the conundrum of differentiating the two groups of conditions in terms of diagnosis and treatment. Here, we systematically review all human and animal studies examining the endocannabinoid system and its biobehavioral correlates in the association between autism and psychosis. Studies indicate overlapping biobehavioral aberrancies between autism and schizophrenia, subject to correction by modulation of the endocannabinoid system. In addition, common cannabinoid-based pharmacological strategies have been identified, exerting epigenetic effects across genes controlling neural mechanisms shared between autism and schizophrenia. Interestingly, a developmental and transgenerational trajectory between autism and schizophrenia is supported by evidence that exogenous alteration of the endocannabinoid system promotes progression to inheritable psychosis phenotypes in the context of biobehavioral autism vulnerability. However, evidence for a diametral association between autism and psychosis is scant. Several clinical implications follow from evidence of a developmental continuum between autism and psychosis as a function of the endocannabinoid system dysregulation.

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“…In the cutting edge we foresee memory type lymphocyte transfusion. Mature memory type lymphocytes are known to directly induce and guide the developments of the hematopoietic cells [1]. We propose that these cells be taken from elder individuals, whose immunity has seen them through many a battle with diseases over time, and be transfused in small quantities, sufficient to direct the development of other lymphocytes, into young infants.…”

Section: Dear Editormentioning

confidence: 99%