Serotonin and dopamine receptors profile on peripheral immune cells from patients with temporal lobe epilepsy

Vieira, Érica Leandro Marciano; Silva, Maria Carolina Machado da; Gonçalves, Ana Paula; Martins, Gabriela Lopes; Teixeira, Antônio Lúcio; Oliveira, Antônio Carlos Pinheiro de; Reis, Helton José

doi:10.1016/j.jneuroim.2021.577534

Cited by 3 publications

(3 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seizures that occur in epilepsy may increase circulating dopamine levels ( Nass et al, 2019 ), which may modulate leukocyte release of inflammatory mediators, which could be a regulatory mechanism of neuroimmune pathways in epilepsy. Increased expression of D1, D2, D4, and D5 were found on monocytes and granulocytes of patients with temporal lobe epilepsy, while D2 expression was increased in lymphocytes ( Vieira et al, 2021 ). Additionally, higher seizure frequency was associated with lower D5 expression on lymphocytes.…”

Section: Regional and Disease-specific Effects Of Dopaminementioning

confidence: 99%

Dopamine, Immunity, and Disease

et al. 2022

View full text Add to dashboard Cite

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition. Dopamine also regulates critical functions in peripheral organs, such as blood pressure, renal activity, and intestinal motility. Beyond these functions, a growing body of evidence indicates that dopamine is an important immunoregulatory factor. Most types of immune cells express dopamine receptors and other dopaminergic proteins, and many immune cells take up, produce, store, and/or release dopamine, suggesting that dopaminergic immunomodulation is important for immune function. Targeting these pathways could be a promising avenue for the treatment of inflammation and disease, but despite increasing research in this area, data on the specific effects of dopamine on many immune cells and disease processes remain inconsistent and poorly understood. Therefore, this review integrates the current knowledge of the role of dopamine in immune cell function and inflammatory signaling across systems. We also discuss the current understanding of dopaminergic regulation of immune signaling in the CNS and peripheral tissues, highlighting the role of dopaminergic immunomodulation in diseases such as Parkinson’s disease, several neuropsychiatric conditions, neurologic human immunodeficiency virus, inflammatory bowel disease, rheumatoid arthritis, and others. Careful consideration is given to the influence of experimental design on results, and we note a number of areas in need of further research. Overall, this review integrates our knowledge of dopaminergic immunology at the cellular, tissue, and disease level and prompts the development of therapeutics and strategies targeted toward ameliorating disease through dopaminergic regulation of immunity. Significance Statement Canonically, dopamine is recognized as a neurotransmitter involved in the regulation of movement, cognition, and reward. However, dopamine also acts as an immune modulator in the central nervous system and periphery. This review comprehensively assesses the current knowledge of dopaminergic immunomodulation and the role of dopamine in disease pathogenesis at the cellular and tissue level. This will provide broad access to this information across fields, identify areas in need of further investigation, and drive the development of dopaminergic therapeutic strategies.

show abstract

Section: Regional and Disease-specific Effects Of Dopaminementioning

confidence: 99%

Dopamine, Immunity, and Disease

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Pollution leads to neuroinflammation, which may play a role in epilepsy. In this situation, leukocytes and inflammatory mediators seem to contribute to a reduction in seizure threshold [91]. Even if their significance is unknown, immune cells from patients with TLE with hippocampal sclerosis exhibit high expression of 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 receptors [91].…”

Section: Neurodevelopmental Disordersmentioning

confidence: 99%

“…In this situation, leukocytes and inflammatory mediators seem to contribute to a reduction in seizure threshold [91]. Even if their significance is unknown, immune cells from patients with TLE with hippocampal sclerosis exhibit high expression of 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 receptors [91]. Platelets are also probably involved in this process by secreting proinflammatory mediators during neuroinflammation and traumatic brain injury (TBI).…”

Section: Neurodevelopmental Disordersmentioning

confidence: 99%

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

Sarrouilhe¹,

Defamie

Mesnil

2021

Biomedicines

View full text Add to dashboard Cite

Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine acting as a neurotransmitter in the central nervous system (CNS), local mediator in the gut, and vasoactive agent in the blood. It has been linked to a variety of CNS functions and is implicated in many CNS and psychiatric disorders. The high comorbidity between some neuropathies can be partially understood by the fact that these diseases share a common etiology involving the serotoninergic system. In addition to its well-known functions, serotonin has been shown to be a mitogenic factor for a wide range of normal and tumor cells, including glioma cells, in vitro. The developing CNS of fetus and newborn is particularly susceptible to the deleterious effects of neurotoxic substances in our environment, and perinatal exposure could result in the later development of diseases, a hypothesis known as the developmental origin of health and disease. Some of these substances affect the serotoninergic system and could therefore be the source of a silent pandemic of neurodevelopmental toxicity. This review presents the available data that are contributing to the appreciation of the effects of the exposome on the serotoninergic system and their potential link with brain pathologies (neurodevelopmental, neurodegenerative, neurobehavioral disorders, and glioblastoma).

show abstract

The Dopamine Gene Receptors (DRD_1-5) Expression Alteration in Psoriasis Patients

Mohamadian

Mortazavi

Makvand

et al. 2022

RAIAD

View full text Add to dashboard Cite

Background: Psoriasis is a chronic inflammatory autoimmune disease that is considered linked to genetic and environmental factors such as stress. Since the neurotransmitter dopamine has a close association with stress configuration, it can be a candidate for relieving psoriasis representation. In addition to the CNS, immune cells can play a decisive role in regulating immune functions through dopamine synthesis and the expression of its receptors. Altered response of immune cells to dopamine as well as distorted expression of dopamine receptors (DRs) in immune cells have been reported in some chronic inflammatory conditions. Objective: This study aims the evaluation of dopamine receptor (DR1-DR5) gene expression in mononuclear blood cells of psoriatic patients in comparison with normal individuals. Method: We isolated peripheral mononuclear cells (PBMCs) from blood samples followed by total RNA extraction, cDNA synthesis, and real-time PCR using specific primer pairs. Result: We found that all types of DRs are expressed in the PBMCs of normal and psoriatic individuals. We also concluded that compared to controls, DR2 and DR4 were overexpressed in psoriasis patients while DR3 was low-expressed. Conclusion: Increased expression of DR2 and DR4 along with decreased expression of DR3 in PBMCs of psoriasis patients not only provide new insight into the pathogenesis of psoriasis but may also be effective in designing future therapeutic strategies attributable to psoriasis.

show abstract

Serotonin and dopamine receptors profile on peripheral immune cells from patients with temporal lobe epilepsy

Cited by 3 publications

References 112 publications

Dopamine, Immunity, and Disease

Dopamine, Immunity, and Disease

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

The Dopamine Gene Receptors (DRD_1-5) Expression Alteration in Psoriasis Patients

Contact Info

Product

Resources

About

Serotonin and dopamine receptors profile on peripheral immune cells from patients with temporal lobe epilepsy

Cited by 3 publications

References 112 publications

Dopamine, Immunity, and Disease

Dopamine, Immunity, and Disease

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

The Dopamine Gene Receptors (DRD1-5) Expression Alteration in Psoriasis Patients

Contact Info

Product

Resources

About

The Dopamine Gene Receptors (DRD_1-5) Expression Alteration in Psoriasis Patients