2020
DOI: 10.1016/j.ejphar.2020.173319
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Serotonin and noradrenaline modulate chronic itch processing in mice

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Cited by 9 publications
(4 citation statements)
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“…Historically, the noradrenergic and serotonergic pathways were known to alleviate thermal, mechanical, and neuropathic pain in animal models ( 32 ). However, recent research has indicated their involvement in acute ( 35 ) and chronic itch ( 36 ). A study by Koga et al ( 37 ) suggested that descending noradrenergic signalling inhibits acute and chronic itch, supporting our findings that yohimbine, an α1/α2 receptor antagonist, suppressed the anti-alloknesis activity of antipruritics.…”
Section: Discussionmentioning
confidence: 99%
“…Historically, the noradrenergic and serotonergic pathways were known to alleviate thermal, mechanical, and neuropathic pain in animal models ( 32 ). However, recent research has indicated their involvement in acute ( 35 ) and chronic itch ( 36 ). A study by Koga et al ( 37 ) suggested that descending noradrenergic signalling inhibits acute and chronic itch, supporting our findings that yohimbine, an α1/α2 receptor antagonist, suppressed the anti-alloknesis activity of antipruritics.…”
Section: Discussionmentioning
confidence: 99%
“…One of the stimuli for non-histaminergic pathways is serotonin. In patients with chronic and inflammatory diseases, serotonin is one of the substances that contributes to the induction of pruritus through its involvement in various pathways [ 40 , 41 ]. In this study we have induced pruritus by serotonin intradermal injection and have shown niclosamide reduce pruritus significantly in 5 mg/kg and 10 mg/kg furthermore we investigated the protein and gen expressions in skin, DRG, spine and brain tissues.…”
Section: Discussionmentioning
confidence: 99%
“…For example, continuous theta burst transcranial magnetic stimulation over the contralateral primary somatosensory cortex has been shown to help reduce the intensity of histamine-induced pruritus. 58 Some antidepressants such as paroxetine, [59][60][61] and anticonvulsants such as gabapentin [62][63][64] and pregabalin 64,65 have also shown antipruritic effects. Therefore, an improved understanding of the pruritus regulation mechanism in the central nervous system of AD may help develop new drugs or physical therapies targeted at the physiological parameters underlying sensory hypersensitivity.…”
Section: Discussionmentioning
confidence: 99%