Serotonin content of foods: effect on urinary excretion of 5-hydroxyindoleacetic acid

Feldman, Jerome M.; Lee, E M

doi:10.1093/ajcn/42.4.639

Cited by 199 publications

(117 citation statements)

References 11 publications

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“…Moreover, many laxatives are made with seed and fruit extracts containing serotonins. Walnut and hickory have high levels of serotonins (25-400 mg/kg), while pineapples, bananas, kiwis, and tomatoes contain about 3-30 mg/kg (Feldman and Lee 1985). In the present study, C. tinctorius seeds were found to contain 4.3 mg/kg serotonin.…”

Section: Identification Of Four Major Chemical Compoundssupporting

confidence: 40%

Serotonins of safflower seeds play a key role in anti-inflammatory effect in lipopolysaccharide-stimulated RAW 264.7 macrophages

et al. 2015

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Serotonins of safflower seeds play a key role in anti-inflammatory effect in lipopolysaccharide-stimulated RAW 264.7 macrophages Dong-Hee Kim ･ Yong-Sun Moon ･ Tae-Soon Park ･ Jun-Ho Son Abstract Safflower (Carthamus tinctorius) seeds are wellknown traditional oriental medicines that have long been used for the remedies of blood stasis and bone formation in east Asia. In this study, ethyl acetate (EtOAc) was used for extraction of the main chemical compounds from C. tinctorius seeds. Four major compounds were identified, acacetin, cosmosiin, N-feruloyl serotonin and N-(p-coumaroyl) serotonin. Each compound was evaluated for its inhibitory activity against the inflammatory process of macrophages. All compounds significantly inhibited production of lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and pro-inflammatory cytokines. The protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were dramatically decreased by serotonins in a dose-dependent manner in LPS-stimulated RAW 264.7 macrophages. These results suggest that serotonin derivatives from safflower seeds may reduce inflammationrelated diseases.

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Section: Identification Of Four Major Chemical Compoundssupporting

confidence: 40%

Serotonins of safflower seeds play a key role in anti-inflammatory effect in lipopolysaccharide-stimulated RAW 264.7 macrophages

et al. 2015

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“…The high antioxidant capacity of kiwifruit may also reduce oxidative damage and consequently improve sleep quality. In addition, kiwifruit is one of the few fruits that has a high serotonin concentration (63), which may be another possible sleep-promoting mechanism of kiwifruit. However, the authors did not measure any of these biological compounds and therefore the mechanism of action remains unclear.…”

Section: Sleep-promoting Foods and Sleep Quality: Experimental Findingsmentioning

confidence: 99%

Effects of Diet on Sleep Quality

St‐Onge

Mikic

Pietrolungo

2016

Advances in Nutrition

399

300

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There is much emerging information surrounding the impact of sleep duration and quality on food choice and consumption in both children and adults. However, less attention has been paid to the effects of dietary patterns and specific foods on nighttime sleep. Early studies have shown that certain dietary patterns may affect not only daytime alertness but also nighttime sleep. In this review, we surveyed the literature to describe the role of food consumption on sleep. Research has focused on the effects of mixed meal patterns, such as high-carbohydrate plus lowfat or low-carbohydrate diets, over the short term on sleep. Such studies highlight a potential effect of macronutrient intakes on sleep variables, particularly alterations in slow wave sleep and rapid eye movement sleep with changes in carbohydrate and fat intakes. Other studies instead examined the intake of specific foods, consumed at a fixed time relative to sleep, on sleep architecture and quality. Those foods, specifically milk, fatty fish, tart cherry juice, and kiwifruit, are reviewed here. Studies provide some evidence for a role of certain dietary patterns and foods in the promotion of high-quality sleep, but more studies are necessary to confirm those preliminary findings. Adv Nutr 2016;7:938-49.

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“…Strict attention to dietary intake of tryptophan may not be essential for diagnostic purposes, but is advisable if accurate monitoring of carcinoid patients is required for research studies. Many foodstuffs are rich in 5HTs,lo3, 104 and it has been demonstrated that excessive ingestion of bananas,6s.los.l06 pineapple 6S,IO? and watnutsl'" significantly increases urinary excretion of 5HIAA.…”

Section: Dietmentioning

confidence: 99%

The Measurement of 5-Hydroxyindoleacetic Acid in Urine

Deacon

1994

Ann Clin Biochem

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Serotonin content of foods: effect on urinary excretion of 5-hydroxyindoleacetic acid

Cited by 199 publications

References 11 publications

Serotonins of safflower seeds play a key role in anti-inflammatory effect in lipopolysaccharide-stimulated RAW 264.7 macrophages

Serotonins of safflower seeds play a key role in anti-inflammatory effect in lipopolysaccharide-stimulated RAW 264.7 macrophages

Effects of Diet on Sleep Quality

The Measurement of 5-Hydroxyindoleacetic Acid in Urine

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