Serotonin-degradative pathways in the toad (Bufo bufo japonicus) brain: clues to the pharmacological analysis of human psychiatric disorders

Takeda, Norihiko

doi:10.1016/1367-8280(94)90051-5

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…Only, N -methylserotonin levels were found elevated in drug abusers. N -methylserotonin is a congener of serotonin and with its derivative bufotenine has shown psychotropic and hallucinogenic effects (Takeda, 1994). Both compounds are elevated in psychiatric disorders characterized by altered perceptions and hallucinations (Takeda, 1994; Takeda et al ., 1995).…”

Section: Discussionmentioning

confidence: 99%

Opioid use affects antioxidant activity and purine metabolism: preliminary results

Mannelli

Patkar

Rozen

et al. 2009

Human Psychopharmacology

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Objective More must be learned about metabolic and biochemical alterations that contribute to the development and expression of drug dependence. Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant compounds and purine metabolism. We examined perturbations of neurotransmitter-related pathways in opioid dependence (OD). Methods In this preliminary study, we used a targeted metabolomics platform to explore whether biochemical changes were associated with OD by comparing OD individuals (n = 14) and non-drug users (n = 10). Results OD patients undergoing short-term methadone detoxification showed altered oxidation–reduction activity, as confirmed by higher plasma levels of α- and γ- tocopherol and increased GSH/GSSG ratio. OD individuals had also altered purine metabolism, showing increased concentration of guanine and xanthosine, with decreased guanosine, hypoxanthine and hypoxanthine/xanthine and xanthine/xanthosine ratios. Other drug use in addition to opioids was associated with partly different biochemical changes. Conclusions This is a preliminary investigation using metabolomics and showing multiple peripheral alterations of metabolic pathways in OD. Further studies should explore the metabolic profile of conditions of opioid abuse, withdrawal and long-term abstinence in relation to agonist and antagonist treatment and investigate biochemical signatures of opioid substances and medications.

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Section: Discussionmentioning

confidence: 99%

Opioid use affects antioxidant activity and purine metabolism: preliminary results

Mannelli

Patkar

Rozen

et al. 2009

Human Psychopharmacology

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“…N-methylserotonin has been previously identified in several plants, including black cohosh (Powell et al, 2008;Nikoli c et al, 2014), Japanese pepper (Yanase et al, 2010), and citrus fruits (Servillo et al, 2015). There is very limited information on whether this compound has beneficial or potentially detrimental physiologic effects (e.g., Takeda, 1994;.…”

Section: Resultsmentioning

confidence: 99%

Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans

Han¹,

Cheng²,

Delannoy-Bruno³

et al. 2022

Cell

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“…Thus, there is great hope that these unusual psychoactive botanicals (Barsuglia et al, 2018; Griffiths et al, 2019) and animal venoms may open new avenues for the development of novel psychotropics (Takeda, 1994; Uthaug et al, 2018; Dos Santos et al, 2019).…”

Section: Methodsmentioning

confidence: 99%

Opportunities in Novel Psychotropic Drug Design from Natural Compounds

Tang

2019

International Journal of Neuropsychopharmacology

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Multiple initiatives at the national and international level support natural drug discovery. Psychiatrists and patients are not well informed about natural psychotropics in general. Existing antidepressant and antipsychotic drugs were developed from atropine, a natural product. Subsequent drug developments were largely based on extension and modification of earlier molecular scaffolds. This limits their mechanisms of action to similar neuropathways. Natural psychotropic substances, particularly those with hallucinogenic and psychedelic properties and different chemical structures, may serve as new paths to novel psychotropic drug development.

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Serotonin-degradative pathways in the toad (Bufo bufo japonicus) brain: clues to the pharmacological analysis of human psychiatric disorders

Cited by 5 publications

References 17 publications

Opioid use affects antioxidant activity and purine metabolism: preliminary results

Opioid use affects antioxidant activity and purine metabolism: preliminary results

Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans

Opportunities in Novel Psychotropic Drug Design from Natural Compounds

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