Serotonin dependent masking of hippocampal sharp wave ripples

Haq, Rizwan ul; Anderson, Marlene; Hollnagel, Jan‐Oliver; Worschech, Franziska; Sherkheli, Muhammad Azahr; Behrens, Christoph; Heinemann, Uwe

doi:10.1016/j.neuropharm.2015.09.026

Cited by 23 publications

(16 citation statements)

References 81 publications

(107 reference statements)

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“…5-HT1A receptors mediate a strong hyperpolarizing effect of 5-HT on granule cells and pyramidal cells through activation of GIRK channels (Andrade and Nicoll, 1987 ; Beck et al, 1992 ; Okuhara and Beck, 1994 ; Piguet and Galvan, 1994 ; Twarkowski et al, 2016 ; Ul Haq et al, 2016 ), reducing firing frequency, and dampening gamma oscillations (Twarkowski et al, 2016 ). This hyperpolarization is opposed by activation of 5-HT4 receptors on pyramidal and granule cells, and 5-HT7 receptors on pyramidal cells that inhibit sAHP currents to increase firing frequency (Bacon and Beck, 2000 ).…”

Section: Neuromodulation Of Dg-ca3 Microcircuitmentioning

confidence: 99%

Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit

Prince

Bacon

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et al. 2016

Front. Synaptic Neurosci.

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The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.

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Section: Neuromodulation Of Dg-ca3 Microcircuitmentioning

confidence: 99%

Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit

Prince

Bacon

Tigaret

et al. 2016

Front. Synaptic Neurosci.

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“…This compares well to a previous study which stated that stimuli sufficient to induce LTP also induce SPW‐Rs when LTP inducing stimulus paradigms were repeated a few times (Behrens et al ., ). During such events we noted sequential activation of neurons as indicated by the different sizes of extracellular action potentials and participation of a given cell with one or at best two action potentials while most other pyramidal cells were silent (Behrens et al ., ; Liotta et al ., ; ul Haq et al ), similar to spontaneous SPW‐Rs in murine CA1 (Valero et al ., ; Ul Haq et al ., ) The type of stimulation activated pyramidal cells at somewhat different latencies due to run time differences to and within the associational network. SPW‐R after HFS for induction of LTP were not that often observed ‐ presumably because many LTP experiments in area CA1 have been done with area CA3 removed.…”

Section: Discussionmentioning

confidence: 65%

“…In many cases the observation of spontaneous activity may also have been neglected since this activity was considered to be a sign of epilepsy. However, there are many distinct differences between epileptiform discharges and the stimulation induced sharp wave ripples (Behrens et al ., ; Jarosch et al ., ; Ul Haq et al ., ). These concern the number of action potentials (Liotta et al ., ), the rises in potassium concentration, sensitivity to gabazine and bicuculline (Behrens et al, ), and consumption of oxygen (Jarosch et al ., ), to name just a few.…”

Section: Discussionmentioning

confidence: 97%

“…Animal procedures were performed in accordance with the guidelines of the European Communities Council and approved by the Regional Berlin Animal Ethics Committee (LaGeSO Berlin: T0096/02 and T0212/02). Wistar rats (aged 6–8 weeks, ∼200 g) or C57Bl/6N mice (age 10–12 weeks) of either sex were decapitated under deep isoflurane anesthesia and horizontal hippocampal slices (400 μm/at bregma −4.7 to −7.3 mm) were prepared and maintained in vitro as previously described (Behrens et al ., ; Ul Haq et al ., ). Extracellular field potentials (FP) were recorded in an interface chamber from stratum pyramidale of CA3 and CA1 with microelectrodes filled with 154 mM NaCl (5–10 MΩ) with a custom made amplifier and stored on computer disk using a CED 1401 interface (Cambridge Electronic Design, Cambridge, UK).…”

Section: Methodsmentioning

confidence: 97%

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Pretreatment with β‐adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus

et al. 2016

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Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs) in acute slices of rat hippocampus in area CA3. Surprisingly, this facilitating effect persists when slices are only pretreated with β-receptor agonists followed by wash out and application of the unspecific β-adrenoreceptor (βAR) antagonist propranolol. During application of βAR agonists repeated stimulation resulted in facilitated induction of SPW-Rs. Since SPW-Rs are thought to be involved in memory replay we studied the effects of βAR-agonists on spontaneous SPW-Rs in murine hippocampus and found that amplitude and incidence of SPW-Rs increased. These effects involve cyclic-AMP and the activation of protein kinase A and suggest a supportive role in memory consolidation. © 2016 Wiley Periodicals, Inc.

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“…As mentioned previously, the effects of ACh on membrane resistance, AHP, and ADP vary widely, especially among interneurons (Cea‐del Rio et al, ; Chapman & Lacaille, ; Cole & Nicoll, ; McQuiston & Madison, , ). Furthermore, adaptation was not included because typical adaptation timescales are in excess of 100 ms (Fleidervish, Friedman, & Gutnick, ; Madison & Nicoll, ), whereas typical ripple events have a duration of about 50 ms (Malerba et al, ; Sullivan et al, ; ul Haq et al, ). Thus, we cannot rule out these effects as being necessary for the cholinergic suppression of ripples.…”

Section: Discussionmentioning

confidence: 99%

A model of cholinergic suppression of hippocampal ripples through disruption of balanced excitation/inhibition

2018

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Sharp wave‐ripples (140–220 Hz) are patterns of brain activity observed in the local field potential of the hippocampus which are present during memory consolidation. As rodents switch from memory consolidation to memory encoding behaviors, cholinergic inputs to the hippocampus from neurons in the medial septum‐diagonal band of Broca cause a marked reduction in ripple incidence. The mechanism for this disruption in ripple power is not fully understood. In isolated neurons, the major effect of cholinergic input on hippocampal neurons is depolarization of the membrane potential, which affects both hippocampal pyramidal neurons and inhibitory interneurons. Using an existing model of ripple‐frequency oscillations that includes both pyramidal neurons and interneurons, we investigated the mechanism whereby depolarizing inputs to these neurons can affect ripple power and frequency. We observed that ripple power and frequency are maintained, as long as inputs to pyramidal neurons and interneurons are balanced. Preferential drive to pyramidal neurons or interneurons, however, affects ripple power and can disrupt ripple oscillations by pushing ripple frequency higher or lower. Thus, an imbalance in drive to pyramidal neurons and interneurons provides a means whereby cholinergic input can suppress hippocampal ripples.

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Serotonin dependent masking of hippocampal sharp wave ripples

Cited by 23 publications

References 81 publications

Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit

Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit

Pretreatment with β‐adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus

A model of cholinergic suppression of hippocampal ripples through disruption of balanced excitation/inhibition

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