Serotonin in Trichinella pseudospiralis: An immunocytochemical study

Abstract

SummaryThis is the fi rst report on the presence and localization of the neurotransmitter serotonin (5-HT) in the nervous system of the nematode Trichinella pseudospiralis, the causative agent of trichinellosis. The orientation of the 5-HT-immunoreactive (5-HT-IR) nerve cells in the adult worm is described. In the anterior region of the worm 5-HT-IR occurs in 7 neurons. Longitudinal nerve cords extend posteriorly from the anterior end. They are connected by transverse commissures. The vulval area is intensively supplied with 5-HT-IR nerve cells and fi bres forming a plexus. Two rows of small 5HT-IR structures, hypodermal glands, are visible along the whole nematode body. Because of the conserved structural features among nematodes the 5-HT-IR neurons observed are likely to have counterparts in the model worm, Caenorhabditis elegans. Some basic differences are evident and demand further study.

Genes‐to‐Pathways Species Conservation Analysis: Enabling the Exploration of Conservation of Biological Pathways and Processes Across Species

“…The results from the analysis of the numbers of entities and reactions follow similar patterns and confirmed previous considerations (Figure 4B). These findings are in agreement with widely published literature, where it is reported that the neurotransmitter serotonin has a very early origin and is expected to be conserved throughout metazoans, as well as prokaryotes and plants, playing a variety of critical roles (Campos et al, 2016; Pilowsky, 2018; Romero‐Reyes et al, 2021; Terenina et al, 2016; Turlejski, 1996). The full output is reported in Supporting Information 3, Case Study 3.…”