1993
DOI: 10.1016/0303-7207(93)90016-d
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Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells

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Cited by 27 publications
(13 citation statements)
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“…In relation to this observation, one of the two mechanisms are detected independently for other G protein-coupled receptors in different cell lines. Indeed, the activation of receptor gene transcription after high concentration of agonist exposure was detected in the expression of 5-HT2 and ␤1-adrenergic receptors (40,41). In a similar vein, receptor RNA destabilization is observed after prolonged agonist exposure in ␣1-adrenergic and M1 muscarinic receptors (42,43).…”
Section: Discussionmentioning
confidence: 99%
“…In relation to this observation, one of the two mechanisms are detected independently for other G protein-coupled receptors in different cell lines. Indeed, the activation of receptor gene transcription after high concentration of agonist exposure was detected in the expression of 5-HT2 and ␤1-adrenergic receptors (40,41). In a similar vein, receptor RNA destabilization is observed after prolonged agonist exposure in ␣1-adrenergic and M1 muscarinic receptors (42,43).…”
Section: Discussionmentioning
confidence: 99%
“…The peripheral expression of 5-HT2 receptor subtypes is still a matter of controversy. If the 5-HT2C receptor is considered to be mainly restricted to the CNS, 5-HT2A receptor expression in the periphery has been reported in platelets, SMC of blood vessels [17,30] and myometrium [31], but not gut or lung [32]. Therefore the 5-HT2B receptor may represent a major 5-HT2-1ike receptor in SMC.…”
Section: Discussionmentioning
confidence: 99%
“…However, in both instances they did not observe a significant difference in the affinity for the ligand or 5HT 2 receptor numbers. 36 Changes in the levels of mRNA without analogous changes in the corresponding protein has also been shown for other receptors, like EGF and interleukin-2, 37,38 and in some instances this was found to be the result of specific processes regulating receptor turnover. 39,40 Moreover, the disparity between mRNA levels and receptor densities could be the result of mechanisms regulating distinct steps of protein synthesis like transcription and translation.…”
Section: Discussionmentioning
confidence: 98%
“…Ligandinduced upregulation of 5HT 2 receptor mRNA has been demonstrated in myometrial SMC. 36 Ligand-mediated upregulation of receptor mRNA levels has also been reported for EGF and inerleukin-2. 37,38 Incubation of SMC with EPA or DHA downregulated the 5HT 2 receptor mRNA.…”
Section: Discussionmentioning
confidence: 99%
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