Serotonin-Mediated Activation of Serotonin Receptor Type 1 Oppositely Modulates Voltage-Gated Calcium Channel Currents in Rat Sensory Neurons Innervating Hindlimb Muscle

Abstract

Serotonin (5-HT); dorsal root ganglia (DRG); peripheral artery disease (PAD); serotonin receptor type 1 (5-HT1); DiI (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate; dimethylsulfoxide (DMSO); 8-hydroxy-2-(di-n-propylamino)tetralin (8OH-DPAT); blood pressure (BP); half-inhibition concentration (IC 50 ); voltage-gated Ca 2+ channel (Ca V ); mean arterial pressure (MAP).