2015
DOI: 10.1016/j.neubiorev.2015.05.013
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Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders

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Cited by 29 publications
(24 citation statements)
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References 256 publications
(251 reference statements)
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“…No matter if the serotonin derives from platelets, mast cells, T-cells, or even from neurons. For example, it influences diseases like gut inflammation (109), allergic asthma (110), rheumatoid arthritis (111), and neuroinflammation such as ALS (60) and autism (112). In the recent years, we could observe the anti-inflammatory effects of antidepressant (influencing serotonin levels in the body) in clinical practice that are, for example, mediated via macrophage modulation (113).…”
Section: Resultsmentioning
confidence: 99%
“…No matter if the serotonin derives from platelets, mast cells, T-cells, or even from neurons. For example, it influences diseases like gut inflammation (109), allergic asthma (110), rheumatoid arthritis (111), and neuroinflammation such as ALS (60) and autism (112). In the recent years, we could observe the anti-inflammatory effects of antidepressant (influencing serotonin levels in the body) in clinical practice that are, for example, mediated via macrophage modulation (113).…”
Section: Resultsmentioning
confidence: 99%
“…Increases in the expression or the presence of active β3 integrin variants and enhanced integrin signalling to focal adhesion kinase (FAK, also known as PTK2), an important non-receptor tyrosine kinase, modulate the function of the serotonin 5-HT transporter (SERT) and thus increase whole-blood serotonin levels, which have been implicated in developmental abnormalities of ASD (Cook and Leventhal, 1996;Dohn et al, 2017;Jaiswal et al, 2015) and in chronic schizophrenia (DeLisi et al, 1981). Currently, it remains unclear whether β3 integrin contributes to ASD and schizophrenia in its capacity as an adhesion receptor and/or as a cytoskeletal regulator, or whether it serves some kind of adhesion-independent scaffolding function that is distinct to those reported in non-neuronal cells.…”
Section: Box 2 Integrin Ligands In the Cnsmentioning
confidence: 99%
“…There is evidence suggesting that the immune system might play a role in the pathophysiology of OCD (for a review see Marazziti, Mucci, & Fontenelle, 2018). Serotonin has shown to be able to modulate a wide range of immune functions; for example, inflammation, phagocytosis, T cell migration, and cytokine production (Jaiswal, Mohanakumar, & Rajamma, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…In patients with PANDAS, the presence of auto-antibodies has been reported providing evidence of the possible autoimmune etiology of this disorder (Nicolini et al, 2015). Genetic variants influencing serotonin availability, and consequently the immune response, as 5-HTTLPR polymorphisms, might be particularly relevant in PANDAS (Jaiswal et al, 2015). Therefore, the identification of genetic variants associated with auto-antibody production in patients with this OCD subtype is crucial to explain the pathophysiology underlying PANDAS.…”
Section: Introductionmentioning
confidence: 99%