Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects

Smith, Gwenn S.; Ma, Yilong; Dhawan, Vijay; Gündüz, Handan; Carbon, Maren; Kirshner, Merick; Larson, Jennifer; Chaly, Thomas; Belakhleff, Abdel; Kramer, Elisse; Greenwald, Blaine S.; Kane, John M.; Laghrissi-Thode, Fouzia; Pollock, Bruce G.; Eidelber, David

doi:10.1002/syn.10088

Cited by 38 publications

(54 citation statements)

References 57 publications

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“…The following LDAEP measurements were performed 10, 30 and 60 min after the infusion had ended. Recording was arranged at these times as neuroendocrinological studies showed that the main effect on the central serotonergic system is to be expected during or right after the infusion (Seifritz et al, 1996;Kapitany et al, 1999;Smith et al, 2002). At the end of each testing day, BDI questionnaire had to be answered once more.…”

Section: Methodsmentioning

confidence: 99%

“…enhancement of serotonin in the synapses by reuptake inhibition (Sanchez and Hyttel, 1999). It is known that the intravenous administration of citalopram leads to significant neuroendocrinological changes of prolactin, cortisol, and growth hormone immediately after infusion (Seifritz et al, 1996;Smith et al, 2002). Furthermore, experiments with in vivo microdialysis showed that citalopram produces an enormous increase of serotonin immediately after injection (Bosker et al, 2001;Muraki et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects?

Uhl

Gorynia

Gallinat

et al. 2006

Human Psychopharmacology

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The loudness dependence of auditory evoked potentials (LDAEP) has been discussed as a non-invasive in vivo marker of central serotonergic function. Evidence for this has been found in animal studies, but studies in humans provide less consistent results. In this study, the relationship between LDAEP and directly modulated central serotonergic activity in healthy subjects was investigated. In a single-blind cross-over design, the LDAEP of female participants (age: 24.0 +/- 2.3 years) was measured under two conditions: (1) infusion of 20 mg citalopram diluted in 250 ml 0.9% saline and (2) infusion of 250 ml 0.9% saline as placebo. LDAEP was measured at five different time points before, during and up to 60 min after drug/placebo administration and dipole source analysis was performed. The increase of the central serotonin activity in response to citalopram was not accompanied by a significant change of the LDAEP compared to the placebo condition. The result underlines that the acceptance of LDAEP as a marker of central serotonergic function still needs further discussion.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects?

Uhl

Gorynia

Gallinat

et al. 2006

Human Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Based on these considerations, an alternative approach has been developed to measure serotonin function in vivo by combining the administration of citalopram with positron emission tomography (PET) measurements of cerebral glucose metabolism (Smith et al, 2002b). The initial studies in healthy controls demonstrated that the intravenous administration of citalopram resulted in steady-state plasma concentrations of citalopram for up to 3 h after the end of infusion and time-dependent increases in cortisol and prolactin levels.…”

Section: Introductionmentioning

confidence: 99%

“…The neuroendocrine (prolactin and cortisol) and cerebral glucose metabolic responses to acute citalopram administration were evaluated as described previously (Smith et al, 2002b). Based on previous basic and clinical research with 5-HTTLPR, it was hypothesized that because the s allele is associated with lower serotonin function, the s allele would be associated with less of a neuroendocrine and metabolic response compared to the l allele.…”

Section: Introductionmentioning

confidence: 99%

Effects of Serotonin Transporter Promoter Polymorphisms on Serotonin Function

Smith

Lotrich

Malhotra

et al. 2004

Neuropsychopharmacol

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The serotonin transporter promoter polymorphism (5-HTTLPR) has been associated with vulnerability to stress-induced depressive symptoms and with the speed and rate of response to antidepressant treatment. The goal of the present study was to evaluate the association between the 5-HTTLPR and the functional response of the serotonin system as measured by the neuroendocrine and cerebral metabolic response to intravenous administration of the selective serotonin reuptake inhibitor citalopram in normal control subjects. Genotyping was performed for 5-HTTLPR insertion/deletion polymorphism long (l) and short (s) variant alleles. The ll genotype was compared with the combined sl þ ss and with the ss genotype alone. Citalopram plasma concentrations did not differ significantly between groups. The s allele was associated with a less of an increase in prolactin and cortisol than the ll genotype. The s allele was associated with greater decreases in left frontal, precentral and middle temporal gyri compared to the ll genotype. The ll genotype was associated with greater decreases in right frontal, insula and superior temporal gyrus compared to the ss genotype. These findings suggest that 5-HTTLPR is associated with an altered functional response of the serotonin system, which may represent a neurobiologic substrate for the differential response to antidepressant treatment in late life and the emergence of neuropsychiatric symptoms in neurodegenerative disorders.

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“…More recent studies have focused on the development and application of a method to measure serotonin function in vivo (Meyer et al, 1999;Hume et al, 2001;Smith et al, 1999Smith et al, , 2002bSmith et al, , 2004. Studies conducted thus far in geriatric depression combining acute and chronic SSRI treatment (citalopram) with measures of cerebral glucose metabolism have shown a differential lateralized pattern of acute metabolic effects in the patients in contrast to comparison subjects that are similar to the response in normal subjects who have a s allele of the serotonin transporter promoter polymorphism compared to those normal subjects with a l allele (Smith et al, 2004).…”

Section: Neurochemical Imaging Approachesmentioning

confidence: 99%

Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research

Smith

Gunning-Dixon

Lotrich

et al. 2007

Neuropsychopharmacol

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Clinical and epidemiological studies have consistently observed the heterogeneous symptomatology and course of geriatric depression. Given the importance of genetic and environmental risk factors, aging processes, neurodegenerative and cerebrovascular disease processes, and medical comorbidity, the integration of basic and clinical neuroscience research approaches is critical for the understanding of the variability in illness course, as well as the development of prevention and intervention strategies that are more effective. These considerations were the impetus for a workshop, sponsored by the Geriatrics Research Branch in the Division of Adult Translational Research and Treatment Development of the National Institute of Mental Health that was held on September 7-8, 2005. The primary goal of the workshop was to bring together investigators in geriatric psychiatry research with researchers in specific topic areas outside of geriatric mental health to identify priority areas to advance translational research in geriatric depression. As described in this report, the workshop focused on a discussion of the development and application of integrative approaches combining genetics and neuroimaging methods to understand such complex issues as treatment response variability, the role of medical comorbidity in depression, and the potential overlap between depression and dementia. Future directions for integrative research were identified. Understanding the nature of geriatric depression requires the application of translational research and interdisciplinary research approaches. Geriatric depression could serve as a model for translational research integrating basic and clinical neuroscience approaches that would have implications for the study of other neuropsychiatric disorders.

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Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects

Cited by 38 publications

References 57 publications

Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects?

Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects?

Effects of Serotonin Transporter Promoter Polymorphisms on Serotonin Function

Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research

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