Serotonin-positive neuroendocrine neoplasm with pancreatic ductal dilation in which cytological immunostaining contributed to the diagnosis

Ariga, Hiroyuki; Kashimura, Junya; Horigome, Yuichi; Okada, Kenta

doi:10.1007/s12328-022-01632-6

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Dysregulated serotonin signaling may also contribute to changes in angiogenesis, impacting tumor vascularization, and involving downstream effects such as the activation of angiogenic factors and pathways like vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF). Additionally, serotonin signaling's potential involvement in the activation of in ammatory pathways may lead to downstream effects involving the upregulation of pro-in ammatory genes and the recruitment of immune cells to the tumor microenvironment [105].…”

Section: Impact Of This Damage Onmentioning

confidence: 99%

Investigating Carcinoid Tumor Oncogenesis through the lens of Developmental Dynamics involved in Small Intestinal Neuroendocrine Cells

Shafi,

Yaqub

2024

Preprint

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Background: Carcinoid tumors from small intestinal Neuroendocrine Cells (SI-NECs) present clinical challenges with increasing incidence. Investigating the genetic architecture is crucial, as dysregulation in transcription factors and signaling pathways contributes to aberrant behavior, including uncontrolled proliferation and hormone secretion. Understanding these mechanisms holds promise for identifying therapeutic targets and biomarkers, not only for carcinoid tumors but also for broader applications in neuroendocrine neoplasms and gastrointestinal malignancies. Methods: Databases, including PubMed, MEDLINE, Google Scholar, and open access/subscription-based journals were searched for published articles without any date restrictions, to investigate the intricate genetic architecture and developmental dynamics underlying the development of carcinoid tumors originating from small intestinal Neuroendocrine Cells (SI-NECs). Based on the criteria mentioned in the methods section, studies were systematically reviewed to investigate carcinoid tumor oncogenesis. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Results: This investigation into the genetic architecture of small intestinal neuroendocrine cells (SI-NECs) reveals intricate dysregulations contributing to carcinoid tumor development. Dysfunctional expression of key transcription factors, including Neurogenin 3, Pdx1, Isl1, Foxa1/2, Hes1, and others, disrupts neuroendocrine differentiation, impacting hormone expression profiles. Chromogranin A dysregulation affects the maturation of SI-NECs, while alterations in Delta-like 1/4 and serotonin contribute to abnormal behavior. Dysfunctional Tcf4 and Gfi1b influence cell fate decisions, and NeuroD1 alterations impact maturation. Dysregulation of GATA factors, Nkx2.2, Sox factors, and Neurotrophins further complicates SI-NECs. Protein Kinase A signaling dysregulation contributes to uncontrolled proliferation. These findings advance our understanding of the complexity of carcinoid tumor development, possibly providing a framework for targeted therapeutic strategies addressing the specific aberrations identified in SI-NECs. Conclusion: The dysregulation in the genetic architecture of small intestinal Neuroendocrine Cells (SI-NECs) precipitates carcinoid tumor development. Alterations in key transcription factors, signaling pathways, and developmental processes disrupt neuroendocrine differentiation, hormone expression, and cell fate determination. Dysfunctional molecular cascades including Notch and Wnt signaling drive uncontrolled proliferation and aberrant hormone secretion characteristic of carcinoid tumors. Understanding the intricate molecular landscape of SI-NEC dysregulation is paramount for targeted therapies. Insights emerging from this research may pave the way for novel interventions aimed at mitigating carcinoid tumor progression and improving patient outcomes.

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Section: Impact Of This Damage Onmentioning

confidence: 99%

Investigating Carcinoid Tumor Oncogenesis through the lens of Developmental Dynamics involved in Small Intestinal Neuroendocrine Cells

Shafi,

Yaqub

2024

Preprint

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A Rare Neuroendocrine Tumor at the Junction of the Cystic and Common Hepatic Ducts: The Value of a Multimodal Approach in Preoperative Diagnosis

Saito,

Ishida,

Sukeda

et al. 2024

Cureus

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Neuroendocrine tumors (NETs) of the biliary tract are extremely rare due to a paucity of Kulchitsky cells. While their preoperative diagnosis remains challenging due to the lack of specific diagnostic markers and imaging findings, there have been no detailed reports describing the diagnostic utility of various imaging modalities for bile duct NETs at the junction of the cystic and common hepatic ducts. We report a case of a woman in her 40s who presented with jaundice and elevated hepatobiliary enzymes. Imaging studies identified a 17 mm × 15 mm × 13 mm nodule at the junction of the cystic and common hepatic ducts. Contrast-enhanced computed tomography (CT) demonstrated a well-enhanced nodule from the early phase, while magnetic resonance imaging showed slightly high intensity on T2-weighted images and strong diffusion restriction. Fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/CT revealed mild 18F-FDG uptake with a maximum standardized uptake value of 3.5. Endoscopic retrograde cholangiopancreatography (ERCP) suggested extramural compression by a submucosal tumor, and endoscopic ultrasonography (EUS) and intraductal ultrasound (IDUS) revealed a well-circumscribed, homogeneous, hypoechoic submucosal nodule. This comprehensive multimodal approach allowed for the inclusion of NET in the preoperative differential diagnosis. The patient underwent cholecystectomy and extrahepatic bile duct resection, and histopathological examination confirmed a World Health Organization grade 1 NET at the junction of the cystic and common hepatic ducts. The patient remains recurrence-free after two years of follow-up. This is the first detailed report demonstrating the potential utility of a multimodal approach, including ERCP, EUS, and IDUS, in the preoperative diagnosis of biliary tract NET at this specific anatomical location, particularly in identifying the characteristic features of a submucosal tumor.

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Serotonin-positive neuroendocrine neoplasm with pancreatic ductal dilation in which cytological immunostaining contributed to the diagnosis

Cited by 2 publications

References 10 publications

Investigating Carcinoid Tumor Oncogenesis through the lens of Developmental Dynamics involved in Small Intestinal Neuroendocrine Cells

Investigating Carcinoid Tumor Oncogenesis through the lens of Developmental Dynamics involved in Small Intestinal Neuroendocrine Cells

A Rare Neuroendocrine Tumor at the Junction of the Cystic and Common Hepatic Ducts: The Value of a Multimodal Approach in Preoperative Diagnosis

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