Serotonin-related gene pathways associated with undifferentiated somatoform disorder

Koh, Kyung Bong; Choi, Eun Hee; Lee, Young Joon; Han, Mooyoung

doi:10.1016/j.psychres.2011.04.002

Cited by 13 publications

(3 citation statements)

References 35 publications

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“…In several clinical groups, somatisation of chronic pain tendencies coincided with hypercortisolism in the hypothalamic pituitary adrenocortical axis (HPA)9, which can aggravate respective illnesses with an inflammatory component610. Genetic association studies have linked the somatisation trait (as measured with Rief's Somatization Index SOMS-2 or the somatisation subscale of Derogatis' SCL-90) significantly to the long alleles of the serotonin transporter (5-HTTLPR, SLC6A4, chromosome 17)1112 and serotonin receptor type 2A (HTR2A, chromosome 13)1213 genes. Furthermore, individuals with somatisation syndrome showed different immunological alterations14, and greater tryptophan depletion effects61516, relative to individuals with major depression.…”

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confidence: 99%

Somatization Severity Associated with Postero-Medial Complex Structures

Lemche

Giampietro

Brammer

et al. 2013

Sci Rep

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Somatisation is a frequent problem in various psychiatric disorders, yet the cerebral mechanisms of somatisation remain unexamined. To test if somatisation is susceptible to emotional states, we investigated relationships between somatisation severity, neural effective connectivity, and autonomic responses to emotional facial expressions. Volunteering participants (N = 20) were presented with facial expressions of happy and sad emotion at three intensity levels (0%–50%–100%) in a fast implicit ER-fMRI design with concurrent derivation of skin conductance levels (SCL). Self-reported somatisation severity as assessed with Rief's SOMS-2 index was correlated with neural response controlling for other clinical traits to ascertain brain bases of somatisation. Regression analyses estimated effective connectivity of main clusters so determined with peripheral autonomic responses. Regions in which magnitude of activity correlated with somatisation severity consisted in both happy and sad conditions of the anterior ventral precuneus (BA7), along with posterior cingulate gyrus (PCC, BA23, sad condition) and anteromedial thalamus (happy condition).

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confidence: 99%

Somatization Severity Associated with Postero-Medial Complex Structures

Lemche

Giampietro

Brammer

et al. 2013

Sci Rep

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“…TPH2 has its most significant impact in the serotonin pathway. The study of somatization in other conditions often also points to serotonin [ 30 , 31 , 32 ]. A study showed increased methylation of the oxytocin receptor gene in 15 patients with motor functional neurological disorder compared with healthy controls [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Genetics of Functional Seizures; A Scoping Systematic Review

Asadi-Pooya,

Hallett,

Mirzaei Damabi

et al. 2023

Genes

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Background: Evidence on the genetics of functional seizures is scarce, and the purpose of the current scoping systematic review is to examine the existing evidence and propose how to advance the field. Methods: Web of science and MEDLINE were searched, from their initiation until May 2023. The following key words were used: functional neurological disorder(s), psychogenic neurological disorder(s), functional movement disorder(s), psychogenic movement disorder(s), functional seizures(s), psychogenic seizure(s), nonepileptic seizure(s), dissociative seizure(s), or psychogenic nonepileptic seizure(s), AND, gene, genetic(s), polymorphism, genome, epigenetics, copy number variant, copy number variation(s), whole exome sequencing, or next-generation sequencing. Results: We identified three original studies. In one study, the authors observed that six (5.9%) patients with functional seizures carried pathogenic/likely pathogenic variants. In another study, the authors observed that, in functional seizures, there was a significant correlation with genes that are over-represented in adrenergic, serotonergic, oxytocin, opioid, and GABA receptor signaling pathways. In the third study, the authors observed that patients with functional seizures, as well as patients with depression, had significantly different genotypes in FKBP5 single nucleotide polymorphisms compared with controls. Conclusion: Future genetic investigations of patients with functional seizures would increase our understanding of the pathophysiological and neurobiological problems underlying this common neuropsychological stress-associated condition.

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“… 13 27 28 29 Moreover, BDNF influences the serotonin neurotransmitters that are linked to somatoform disorder and hypochondriasis. 12 30 31 32 33 On these bases, we assumed that there may be some changes of the BDNF levels of the patients with somatization disorder compared with the healthy control volunteers. The aim of the present study was to clarify the magnitudes of the relationships between somatization disorder and serum BDNF.…”

Section: Introductionmentioning

confidence: 99%

Decreased Plasma BDNF Levels of Patients with Somatization Disorder

Kang

Park

Kim

et al. 2016

Psychiatry Investig

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ObjectiveBrain-derived neurotrophic factor (BDNF), one of the most abundant and important neurotrophins, is known to be involved in the development, survival, maintenance, and plasticity of neurons in the nervous system. Some studies have suggested that BDNF may play a role in the pathophysiology of several psychiatric illnesses such as depression and schizophrenia. Similarly, it is likely that the alteration of BDNF may be associated with the neuro-modulation that contributes to the development of somatization disorder.MethodsThe purpose of this study was to determine whether there is an abnormality of plasma BDNF levels in patients with somatization disorder, and to analyze the nature of the alteration after pharmacotherapy using an enzyme-linked immunosorbent assay (ELISA).ResultsThe plasma BDNF levels of the patients with a somatization disorder were significantly lower compared with those of the control volunteers (83.61±89.97 pg/mL vs. 771.36±562.14 pg/mL); moreover, the plasma BDNF levels of those patients who received an antidepressant were significantly increased after the treatment (118.13±91.45 pg/mL vs. 72.92±88.21 pg/mL).ConclusionThese results suggest that BDNF may play a role in the pathophysiology of somatization disorder.

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Serotonin-related gene pathways associated with undifferentiated somatoform disorder

Cited by 13 publications

References 35 publications

Somatization Severity Associated with Postero-Medial Complex Structures

Somatization Severity Associated with Postero-Medial Complex Structures

Genetics of Functional Seizures; A Scoping Systematic Review

Decreased Plasma BDNF Levels of Patients with Somatization Disorder

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