“…In clinical practice, however, various specific factors have to be considered. It concerns the higher vulnerability for anticholinergic and motor side effects as well as delirious states, drug-drug interactions and even a serotonin syndrome [24]. Concerning the available antidepressants, the SSRI citalopram seems to be relatively safe since its efficacy is demonstrated in the elderly with comparable neurologic or somatic co-morbidity [4,5,7,20], and no significant drug-drug interactions have been reported [17,21,22].…”