Serotonin syndrome following SSRI mono-therapy

An Unusual Presentation of Sertraline and Trazodone Overdose

“…5 The probability of serotonin syndrome increases significantly when SSRIs are used in combination with a monoamine oxidase inhibitor, but this syndrome has also been reported when SSRIs are used alone or administered with other serotonergtic agents such as lithium, buspirone, tramadol, or dextromethorphan. 5,6 Overdose situations in which SSRIs are combined with other serotonergic agents, therefore, have the potential for serious toxicity.…”