Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Bliziotes, Michael; Eshleman, Amy J.; Burt‐Pichat, Brigitte; Zhang, X.-W.; Hashimoto, Joel G.; Wiren, Kristine M.; Chenu, Chantal

doi:10.1016/j.bone.2006.06.009

Cited by 113 publications

(98 citation statements)

References 51 publications

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“…Functional 5-hydroxytryptamine (5-HT) transporters and receptors are present in osteoblasts, osteocytes, and osteoclasts, and stimulation of these receptors influences bone cell activities [30,31]. Consistent with this, use of SSRIs, but not tricyclic antidepressants, was associated with increased rates of bone loss at the hip in older women [32] and men [33].…”

Section: Discussionmentioning

confidence: 89%

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

et al. 2014

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Summary-We used data from a large, prospective Canadian cohort to assess the association between selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) and fracture. We found an increased risk of fractures in individuals who used SSRI or SNRI, even after controlling for multiple risk factors.Introduction-Previous studies have suggested an association between SSRIs and increasing risk of fragility fractures. However, the majority of these studies were not long-term analyses or were performed using administrative data and, thus, could not fully control for potential confounders. We sought to determine whether the use of SSRIs and SNRIs is associated with increased risk of fragility fracture, in adults aged 50+.

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Section: Discussionmentioning

confidence: 89%

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

et al. 2014

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“…24 One of the possible mechanisms by which antidepressant use may contribute to fracture risk is the effect that antidepressants could have on the microarchitecture of bone. 34 Also, the use of antidepressants has been associated with an increased risk of falling 35 and depression itself might also increase fracture risk. 36 Strengths of our study include its reasonable sample size and the duration of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Risk of fractures in patients with multiple sclerosis

Bazelier¹,

Staa²,

Uitdehaag³

et al. 2012

Neurology

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Objective: To examine the risk of fracture in patients with multiple sclerosis (MS) compared with population-based controls.Methods: A population-based cohort study was performed in the Dutch PHARMO Record Linkage System (1998System ( -2008. Patients with MS (n ϭ 2,415) were matched by year of birth, sex, and practice to up to 6 patients without MS (controls). We used Cox proportional hazards models to estimate the hazard ratio (HR) of fracture in MS. Time-dependent adjustments were made for age, history of disease, and drug use. Results

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“…Physiological roles of 5-HT in osteoblasts have already been reported: for example, 5-HT potentiated the parathyroid hormone-induced increase in AP-1 activity in osteoblastic UMR106 cells (2). In a recent study by Bliziotes et al (2006), 5-HT was reported to stimulate the release of PGE 2 in clonal ostocytic MLO-Y4 cells (3). Their observation indicates that several kinds of osteoblast-like cells are endowed with some functional 5-HT receptors.…”

mentioning

confidence: 92%

Expression of mRNA for 5-HT2 Receptors and Proteins Related to Inactivation of 5-HT in Mouse Osteoblasts

et al. 2009

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Abstract. We analyzed the expression of 5-HT 2 receptors and proteins related to inactivation of 5-HT in primary cultures of mouse osteoblasts. The mRNA for the 5-HT 2A receptor was detectable in anaplastic osteoblasts as well as in differentiated and matured osteoblasts. The mRNA for the 5-HT 2B receptor and 5-HT transporter was undetectable in anaplastic osteoblasts and became detectable in differentiated and matured osteoblasts. It was suggested that 5-HT might regulate the proliferation of anaplastic osteoblasts through the 5-HT 2A receptor without control by 5-HT-inactivating mechanisms. The differentiation and maturation of osteoblasts might be regulated by the activation of the 5-HT 2B receptor under the control of 5-HT inactivation.

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Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells

Cited by 113 publications

References 51 publications

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

Risk of fractures in patients with multiple sclerosis

Expression of mRNA for 5-HT2 Receptors and Proteins Related to Inactivation of 5-HT in Mouse Osteoblasts

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