Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Anxiety Reactivity in Daily Life: A Daily Process Approach to Gene-Environment Interaction

Gunthert, Kathleen C.; Conner, Tamlin S.; Armeli, Stephen; Tennen, Howard; Covault, Jonathan; Kranzler, Henry R.

doi:10.1097/psy.0b013e318157ad42

Cited by 123 publications

(130 citation statements)

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“…An excellent example in the psychiatry literature of the definition of an endophenotype using genetics, ERP, neuroimaging, and behavioral testing, is the work focusing on the serotonin transporter gene and its association to mood disorders and personality traits, most robustly studied in social anxiety and shyness in children (Battaglia et al 2005;Canli and Lesch 2007;Gunthert et al 2007;Hayden et al 2007;Serretti et al 2006). Two common alleles of the serotonin transporter promoter (5-HTTPR), short and long, have been differentially associated with: level of serotonin uptake and transport, amygdala activity in response to angry or fearful faces, and behavioral phenotypes such as anxiety, avoidant personalities and shyness.…”

Section: The Futurementioning

confidence: 99%

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Jeste

Nelson

2008

J Autism Dev Disord

162

160

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In this paper we critically review the literature on the use of event related potentials (ERPs) to elucidate the neural sources of the core deficits in autism. We review auditory and visual ERP studies, and then review the use of ERPs in the investigation of executive function. We conclude that, in autism, impairments likely exist in both low and higher level auditory and visual processing, with prominent impairments in the processing of social stimuli. We also discuss the putative neural circuitry underlying these deficits. As we look to the future, we posit that tremendous insight can be gained by applying ERPs to the definition of endophenotypes, which, in turn, can facilitate early diagnosis and the creation of informed interventions for children with autism. KeywordsEvent related potential (ERP); Autism; Auditory processing; Visual processing Since autism was first described by Kanner over fifty years ago (Kanner 1943), the neurobiology of this disorder has become the focus of intense scientific investigation. While extensive efforts have been made in describing the behaviors that define autism, only in recent years has progress been made to elucidate the underlying neural circuitry involved in autism, through structural and, more recently, functional neuroimaging. Through these studies has come a heightened interest in aberrant neural circuitry in autism. Of the neuroimaging tools that have been used to elucidate brain circuitry, functional electrophysiology stands alone in capacity to define early (i.e. in infancy) neural markers and endophenotypes. This technique, therefore, warrants further scrutiny. Using functional electrophysiology, defined by evoked potentials and then by event related potentials (ERPs), researchers have begun to elucidate sources of the core deficits in autism

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Section: The Futurementioning

confidence: 99%

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Jeste

Nelson

2008

J Autism Dev Disord

162

160

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“…In addition, because electronic diaries contain automatic timestamp information for entries, they allow researchers to monitor and assess participant entries for compliance and reliability (Ebner-Priemer & Trull, 2009). Electronic diaries, sometimes referred to as ecological momentary assessment or ambulatory assessment, are now increasingly used by researchers investigating psychological phenomena such as emotional functioning, mood disorders, stress, organizational behavior, and health treatments (Alpers, 2009;Gunthert, Conner, Armeli, Tennen, Covault, & Kranzler, 2007;EbnerPriemer et al, 2007;Ebner-Priemer, & Sawitzki, 2007;Fahrenberg, Myrtek, Pawlik, & Perrez, 2007;Myrtek, Aschenbrenner, & Brugner 2005;Hoppmann & Riediger, 2009;Jamison et al, 2001;King, Lluch, Stubbs, & Blundell, 1997;Klumb, Elfering, & Herre, 2009).…”

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confidence: 99%

CUE: The continuous unified electronic diary method

Ellis-Davies

Sakkalou

Fowler³

et al. 2012

Behav Res

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In the present article, we introduce the continuous unified electronic (CUE) diary method, a longitudinal, event-based, electronic parent report method that allows real-time recording of infant and child behavior in natural contexts. Thirty-nine expectant mothers were trained to identify and record target behaviors into programmed handheld computers. From birth to 18 months, maternal reporters recorded the initial, second, and third occurrences of seven target motor behaviors: palmar grasp, rolls from side to back, reaching when sitting, pincer grip, crawling, walking, and climbing stairs. Compliance was assessed as two valid entries per behavior: 97 % of maternal reporters met compliance criteria. Reliability was assessed by comparing diary entries with researcher assessments for three of the motor behaviors: palmar grasp, pincer grip and walking. A total of 81 % of maternal reporters met reliability criteria. For those three target behaviors, age of emergence was compared across data from the CUE diary method and researcher assessments. The CUE diary method was found to detect behaviors earlier and with greater sensitivity to individual differences. The CUE diary method is shown to be a reliable methodological tool for studying processes of change in human development.

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“…Methods for studying the individuals' ongoing behaviour, physiology, and experience, as well as the environmental contexts in which they occur are currently being revived and further developed. Contextualised behavioural measurements are obtained, for example, in experimental "miniature situations" in objective personality tests sensu Cattell (Cattell & Warburton, 1967;Kubinger, 2009) or in daily life settings in the field of ambulatory monitoring (Gunthert et al 2007;Mehl & Conner, 2012;Mehl & Pennebaker, 2003) to which Cattell (1957) referred to as Test-data and Life-data respectively.The behavioural study of individual differences involves more than just behavioural measurements, however. It requires meta-theoretical concepts and methodological approaches that differ in parts from those that have been established for judgment-based investigations of individual differences.…”

mentioning

confidence: 99%

Contextualised behavioural measurements of personality differences obtained in behavioural tests and social observations in adult capuchin monkeys (Cebus apella)

Uher

Addessi

Visalberghi

2013

Journal of Research in Personality

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HighlightsPersonality differences studied with a new philosophy-of-science paradigm featuring a behavioural research framework. A non-lexical taxonomic approach applied for comprehensive emic/bottom-up construct generation. In 15 test and 2 group situations, 146 contextualised behaviours measured repeatedly. This is the first comprehensive study on personality differences in capuchin monkeys. Overall no age and sex differences found, but long-term effects of early life experiences. AbstractWe applied a new framework for behavioural research on personality differences in 26 adult tufted capuchin monkeys. Using the Behavioural Repertoire x Environmental Situations Approach, we generated systematically 20 non-lexical emic personality constructs that have high ecological validity for this species. For construct operationalisation, we obtained 146 contextualised behavioural measures repeatedly in 15 experimental situations and 2 group situations using computerised and video-assisted methods. A complete repetition after a 2-3-week break within a 60-day period yielded significant test-retest reliability from individualoriented and variable-oriented viewpoints at different levels of aggregation. In accordance with well-established findings on cross-situational consistency, internal consistency was only moderate. This new and important finding highlights fundamental differences between behavioural approaches and judgment-based approaches to personality differences.Key words: age differences; Behavioural Repertoire x Environmental Situations Approach; capuchin monkeys; cross-situational consistency; early life experiences; individual behaviour; methodology; personality differences; sex differences; situation-behaviour-profiles Uher, J., . Contextualised behavioural measurements of personality differences obtained in behavioural tests and social observations in adult capuchin monkeys (Cebus apella). Journal of Research in Personality, 47, 427-444. http://dx.doi.org/10.1016/j.jrp.2013 www.primate-personality.net 2/36 Theoretical BackgroundPsychologists increasingly advocate for taking behavioural measurements of personality differences in greater consideration (Baumeister, Vohs, & Funder, 2007;Furr, 2009). Methods for studying the individuals' ongoing behaviour, physiology, and experience, as well as the environmental contexts in which they occur are currently being revived and further developed. Contextualised behavioural measurements are obtained, for example, in experimental "miniature situations" in objective personality tests sensu Cattell (Cattell & Warburton, 1967;Kubinger, 2009) or in daily life settings in the field of ambulatory monitoring (Gunthert et al. 2007;Mehl & Conner, 2012;Mehl & Pennebaker, 2003) to which Cattell (1957) referred to as Test-data and Life-data respectively.The behavioural study of individual differences involves more than just behavioural measurements, however. It requires meta-theoretical concepts and methodological approaches that differ in parts from those that have been established f...

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Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Anxiety Reactivity in Daily Life: A Daily Process Approach to Gene-Environment Interaction

Abstract: Our findings highlight the potential value of focusing on genetic vulnerability in the context of everyday environmental triggers.

Cited by 123 publications

References 35 publications

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

CUE: The continuous unified electronic diary method

Contextualised behavioural measurements of personality differences obtained in behavioural tests and social observations in adult capuchin monkeys (Cebus apella)

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