Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort

Vaht, Mariliis; Merenäkk, Liis; Mäestu, Jarek; Veidebaum, Toomas; Harro, Jaanus

doi:10.1007/s00213-013-3427-8

Cited by 31 publications

(24 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies on the association of the 5-HTTLPR genotype with alcohol consumption have been equivocal in their conclusions, but analysis of the two birth cohorts of the ECPBHS has suggested a possible reason for the inconsistency in findings: Carriers of the s-allele, with higher amygdalar response to threats, have a highly variable association with alcohol use. Specifically, we found a statistically highly significant genotype × gender × birth cohort interaction effect on the age of first consumption of half a unit of alcohol [21]: While in the older cohort of the ECPBHS the female s/s homozygotes were the group that started to drink alcohol later than any other group, the female 5-HT-TLPR homozygotes of the younger cohort made the alcohol debut earlier than males and on average at almost three years younger age than their counterparts in the older cohort.…”

mentioning

confidence: 78%

Does psychiatric molecular genetics need to account for the birth cohort effect?

Харро

Laas

Вахт

et al. 2019

V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

View full text Add to dashboard Cite

Major psychiatric disorders including alcohol use disorder are considered multigenic and the smallness of effects of individual genes may be attributed to either complex biological mechanisms or geneenvironment interactions. The latter explanation is highlighted by the relatively fast changes in secular trends and in cohort effects on alcohol use disorder. Interactions of candidate gene variants with birth cohort have been found in the Estonian Children Personality Behaviour and Health Study, a longitudinal investigation from 1998 with a sample highly representative of birth cohorts within a region. Such interactions regarding initiation of alcohol use or alcohol use disorder have been revealed for e.g., 5-HTTLPR, VMAT1, OXR and NRG1, and suggest that rapid alterations in the socioeconomic environment promote changes in the genetic vulnerability to environmental risks factors such as alcohol.

show abstract

mentioning

confidence: 78%

Does psychiatric molecular genetics need to account for the birth cohort effect?

Харро

Laas

Вахт

et al. 2019

V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

View full text Add to dashboard Cite

show abstract

“…It is of notice that genotype associations with behavioural measures in these two birth cohorts have not been similar in a variety of previous analyses. Indeed, for behaviours with strong secular changes such as age of alcohol use debut, striking genotype by birth cohort interactions have been revealed (Vaht et al, 2014(Vaht et al, , 2016. These may be related to changes in attitudes toward alcohol use in adolescents and alcohol availability during the societal changes that were very rapid in some of the countries of Central and Eastern Europe during the period when the two birth cohorts were in critical age .…”

Section: Discussionmentioning

confidence: 99%

Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour

et al. 2019

Self Cite

View full text Add to dashboard Cite

Highlights• Orexins are involved in the regulation of stress response • The HCRTR1 rs2271933 G>A genotype was associated with aggressiveness • A/A homozygotes were more aggressive and relapsed to drunk driving • A-allele carriers were more frequently involved in traffic accidents• The genotype effect is sensitive to stressful life events AbstractOrexins, alternatively called hypocretins, are neuropeptides with crucial role in maintaining wakefulness. The orexin system is thought to mediate a coordinated defense response but thus far investigated from the flight, but never fight, response perspective. An HCRTR1 gene variant (rs2271933 G > A) leading to amino acid substitution (Ile408Val) has been associated with migraine and mood disorders. We genotyped, and assessed aggressive behaviour in both birth cohorts (n=655 and 583) of the Estonian Children Personality Behaviour and Health Study (ECPBHS). Measures of aggressiveness were collected at age 25 or 33 and data on stressful life events (SLE-s) at age 15. Violations of traffic law were monitored in the samples of the Estonian Psychobiological Study of Traffic Behaviour. In both birth cohorts of the ECPBHS, the HCRTR1 the A/A homozygotes reported higher aggression in both Buss-Perry Aggression Questionnaire and the Life History of Aggression Interview. With either measure of aggressiveness, the HCRTR1 genotype effect was dependent on experience of SLE, the highest level of aggressiveness increase by environment being found in female A/A homozygotes. The HCRTR1 A/A homozygotes scored higher in the ANGER facet of the Affective Neuroscience Personality Scale, while such an effect on FEAR was found only in females. Male HCRTR1 A/A homozygotes were more likely to relapse into drunk driving of a passenger car, and in two independent samples the A-allele carriers were causing traffic accidents more often. Conclusively, self-report, interview, and traffic record data converge indicating that the HCRTR1 Ile408Val genotype is associated with aggressiveness and breach of law.This article is part of the Special Issue entitled "Current status of the neurobiology of aggression and impulsivity".

show abstract

“…One study in a Han Chinese population reported that alcohol-dependent patients were more likely to carry the low-functional genotypes of 5-HTTLPR, such as SS, SL G , or L G L G [47], while other studies which considered triallelic functional 5-HTTLPR found no such association between the selected SNP and alcohol dependence [48]. Evidence from animal and human studies supports a role for 5 - HTTLPR gene-environment interactions in the development of excessive alcohol intake [49,50]. Studies in humans have provided evidence for earlier and heavier alcohol use only among 5 - HTTLPR S allele carriers following stressful life events [51,52], while another recently published study found no significant environment × genotype interaction among males, but it found that in the general population male carriers of 5-HTTLPR SS reported the highest consumption of alcohol [50].…”

Section: Discussionmentioning

confidence: 99%

“…Evidence from animal and human studies supports a role for 5 - HTTLPR gene-environment interactions in the development of excessive alcohol intake [49,50]. Studies in humans have provided evidence for earlier and heavier alcohol use only among 5 - HTTLPR S allele carriers following stressful life events [51,52], while another recently published study found no significant environment × genotype interaction among males, but it found that in the general population male carriers of 5-HTTLPR SS reported the highest consumption of alcohol [50]. In risk settings, binge drinking decreased with each copy of the S allele [53].…”

Section: Discussionmentioning

confidence: 99%

Alcohol Dependence and Genetic Variability in the Serotonin Pathway among Currently and Formerly Alcohol-Dependent Males

et al. 2015

View full text Add to dashboard Cite

Background: Genes involved in the serotonin pathway may determine the susceptibility to alcohol dependence and its severity. The present study explored whether specific polymorphisms in the serotonin pathway could be associated with alcohol dependence or alcohol-related psychopathological symptoms. Methods: The cohort comprised 101 currently and 100 formerly alcohol-dependent males, as well as 97 male healthy blood donors. The following questionnaires were employed: the Alcohol Use Disorders Identification Test, the Zung Depression and Anxiety Scale, the Brief Social Phobia Scale, the Yale-Brown Obsessive Compulsive Scale and Obsessive Compulsive Drinking Scale, and the Buss-Durkee Hostility Inventory. Subjects were genotyped for bi- and triallelic SLC6A4 5-HTTLPR,HTR1A rs6295, and HTR1B rs13212041. Results: Statistical differences in bi- and triallelic SLC6A4 5-HTTLPR genotype distribution were observed between the 3 groups investigated (p = 0.008 and p = 0.023, respectively); however, no gene-dose effect was observed. The severity of the alcohol problems was higher in currently alcohol-dependent subjects with the 5-HTTLPR LL (p = 0.039) and L′L′ genotypes (p = 0.027). Formerly dependent subjects with the 5-HTTLPR S′S′ genotype showed more social anxiety, depressive, and anxiety traits (p = 0.009, p = 0.006, and p = 0.036, respectively). Healthy controls with the 5-HTTLPR SS genotype showed more traits of social anxiety (p = 0.020). Conclusions: Our findings suggest that bi- and triallelic SLC6A4 5-HTTLPR has some effects on the severity of alcohol dependence. Triallelic 5-HTTLPR was associated with social anxiety, anxiety, and depressive traits in alcohol-dependent subjects.

show abstract

Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort

Abstract: Expression of genetic vulnerability to alcohol use is influenced by birth cohort effects. The 5-HTTLPR genotype is associated with alcohol consumption in general population, but the effect depends on gender and birth cohort.

Cited by 31 publications

References 72 publications

Does psychiatric molecular genetics need to account for the birth cohort effect?

Does psychiatric molecular genetics need to account for the birth cohort effect?

Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour

Alcohol Dependence and Genetic Variability in the Serotonin Pathway among Currently and Formerly Alcohol-Dependent Males

Contact Info

Product

Resources

About