Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity

Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

“…These genotype frequencies are distributed in a manner consistent with the Hardy-Weinberg equilibrium and are similar to those observed in previous studies by Lesch et al (1996) (LL-33%, LS-49%, SS-18%) and Preuss et al (2000) (LL-28%, LS-58%, SS-14%). Ages of participants ranged from 18 to 66 years, with a mean age of 41.0 years and an average duration of 11.6 years of problem drinking.…”

The lack of genotype–phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects

“…Regarding clinical and biochemical characteristics that might have affected presented data, no significant association was detected between 5-HTTLPR variants and systolic or diastolic arterial blood pressure, waist circumference, BMI, plasma lipid levels, plasma fasting glucose, or insulin in healthy men [33], and in addition, our subjects were matched for BMI. In agreement with previous data [24,28], no significant differences were found between male and female carriers of L/L, L/S or S/S genotypes, as well as long or short alleles. In line with previous findings suggesting lack of correlation between age and 5-HTT genotypes [33] or platelet 5-HT concentration [22], in our study age was not significantly correlated with platelet 5-HT concentration subdivided according to the 5-HTT genotypes.…”

Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics

“…[48][49][50] All participants were recruited as in patients from a ward for treatment of alcohol dependence. All patients were older than 18 years and met ICD10 and DSM-IV criteria for alcohol dependence.…”