Serotonin2A Receptor Modulation of D1 Dopamine Receptor-Mediated Grooming Behavior

Scalzitti, Joanne M.; Cervera, L.; Smith, Christine E.; Hensler, Julie G.

doi:10.1016/s0091-3057(98)00260-3

Cited by 14 publications

(13 citation statements)

References 26 publications

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“…Interestingly, while 5-HT 2A receptor antagonists can block some behavioral effects of dopamine-releasing agents (Schmidt et al 1992;Martin et al 1997; present results), they generally do not alter the behavioral effects of directly acting D 1 receptor agonists (Molloy and Waddington 1987;O'Neill et al 1999;Scalzitti et al 1999). It will be of interest, in future experiments, to examine whether d-amphetamine's effects on temporal differentiation can be mimicked by directly acting D 1 receptor agonists, and whether MDL-100907 and other 5-HT 2A receptor antagonists can discriminate between the effects of direct and indirect D 1 receptor stimulation.…”

Section: Discussionmentioning

confidence: 41%

Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors

et al. 2006

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Section: Discussionmentioning

confidence: 41%

Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors

et al. 2006

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“…An agonist of 5-HT2c receptor increases grooming behavior 66 and a 5-HT2A receptor antisense oligonucleotide, which increase 5-HT2A cortical sites and central function, and an agonist of 5-HT2 receptors, attenuated grooming behavior induced by an agonist of D1 dopamine receptors. 68 Studies involving OT and other systems, such as dopamine and serotonin, will help to elucidate their participation in the modulation of grooming behavior.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

et al. 2007

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Oxytocin (OT) is a neurosecretory nonapeptide synthesized in hypothalamic cells that project to the neurohypophysis as well as to widely distributed sites in the central nervous system. Central OT microinjections induce a variety of cognitive, sexual, reproductive, grooming and affiliative behaviors in animals. Obsessive-compulsive disorder (OCD) includes a range of cognitive and behavioral symptoms that bear some relationship with OT. Here, we study the neuroanatomical and cellular substrates of the hypergrooming induced by administration of OT in the central nucleus of amygdala (CeA). In this context, this hypergrooming is considered as a model of compulsive behavior. Our data suggest a link between the CeA and the hypothalamic grooming area (HGA). The HGA includes parts of the paraventricular nucleus and the dorsal hypothalamic area. Our data on colocalization of OT (immunohistochemistry for peptide), OT receptor (binding assay) and its retrogradely labeled cells after Fluoro-Gold injection in the CeA suggest that CeA and connections are important substrates of the circuit underlying this OT-dependent compulsive behavioral pattern.

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“…Grooming has also been primarily regarded as a behaviour, the purpose of which is care of the body surface in animals. However, mild stress such as exposure to a novel environment is known to induce grooming behaviour and central dopaminergic activation has been reported to be involved in grooming behaviour via D 1 receptor (Scalzitti et al, 1999). During the total 20 minute session, grooming showed a significant decrease effect.…”

Section: Discussionmentioning

confidence: 96%

Neuropharmacological effects of <em>Alchornea cordifolia</em> (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice

Akanmu¹,

Adeloye²,

Obuotor³

et al. 2012

Int. J. Bio. Chem. Sci

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Alchornea cordifolia (Euphorbiaceae) is a common plant, which has featured prominently in traditional medicinal practice. It has been reported that the decoction of the leaves is taken as central nervous system stimulant. This work was therefore undertaken to examine the central nervous system effects. The neuropharmacological profile of the plant was determined in mice to which the plant extract had been orally administered at respective doses of 250, 500 and 1,000 mg/kg. The behavioral models used included noveltyinduced behaviors (locomotion, rearing and grooming), holeboard and elevated plus maze (anxiolytic) and forced swimming (antidepressant). The Y-maze was used for the investigation of the plant extract on locomotion, learning and memory. The results obtained showed that both locomotor and rearing activities were significantly decreased at the highest dose of 1000 mg/kg orally, while grooming behavior was significantly decreased at all the doses administered. In the hole board experiment, the frequency of head-dips was decreased significantly at 1000 mg/kg, while there was no significant effect observed in the elevated plus maze. Y-maze model results showed that it had no significant effect on spatial memory. There was no significant difference in the immobility duration due to administration of the extract in the forced swimming test. In conclusion, the present study showed that although the ethanolic leaf extract of A. cordifolia exhibited some central inhibitory effect, it is devoid of anxiolytic, antidepressant activities and has no significant effect on learning and memory in mice.

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Serotonin2A Receptor Modulation of D1 Dopamine Receptor-Mediated Grooming Behavior

Cited by 14 publications

References 26 publications

Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors

Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

Neuropharmacological effects of <em>Alchornea cordifolia</em> (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice

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