Serotonin6 receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats

Age-Related Change in 5-HT6 Receptor Availability in Healthy Male Volunteers Measured with 11C-GSK215083 PET

“…An age-related decline in 5-HT 2A receptor availability has been shown in the hippocampus and amygdala (15). Because both 5-HT 2A and 5-HT 6 receptors are expressed in the amygdala (29,30) and hippocampus (31,32), the absence of an age effect in these ROIs in our study could be confounded by the relative proportion of 5-HT 6 and 5-HT 2A receptors, low BP ND , or high variability in these small ROIs. Therefore, specific conclusions on changes in 5-HT 6 receptor availability with age in these regions cannot be drawn from our present results.…”

Neuropsychiatric Disorders in Parkinson’s Disease: What Do We Know About the Role of Dopaminergic and Non-dopaminergic Systems?

“…Activation of prelimbic 5-HT 1A receptors produced antidepressant effects while their blockade favored depressive-like behavior in the MFB-lesioned rats (Hui et al, 2014). It has also been shown that the modulation of 5-HT 6 or 5-HT 7 receptors within either the prelimbic cortex or the hippocampus had an impact on depressive-like behaviors (Liu et al, 2015;Zhang et al, 2015Zhang et al, , 2016. After bilateral injection of 6-OHDA in the MFB, rats exhibited depressive-like behavior, which was dramatically exacerbated when lesions of serotonergic and noradrenergic neurons were combined with the DA one (Faggiani et al, 2015).…”

“…Animal model Target region (+ treatment if any) Reduced/reversed by Study Depression-like 6-OHDA-lesioned mice Bilateral dorsolateral striatum Pramipexole, Reboxetine Bonito-Oliva et al, 2014 Bilateral SNc L-DOPA, pramipexole Chiu et al, 2015 6-OHDA-lesioned rats Bilateral dorsal striatum Branchi et al, 2008 Bilateral medial VTA Drui et al, 2014 Bilateral MFB Faggiani et al, 2015 Bilateral MFB and 5-HT/NA lesions Faggiani et al, 2015 Bilateral SNc L-DOPA, Ropinirole, SKF38393, Sumanirole, PD-128907 Carnicella et al, 2014;Drui et al, 2014 Bilateral SNc Ketamine, Imipramine Vecchia et al, 2018 Bilateral SNc Santiago et al, 2010 Bilateral SNc and olfactory bulb Ilkiw et al, 2019 Bilateral ventrolateral dorsal striatum Tadaiesky et al, 2008;da Silva et al, 2016 Olfactory bulb Ilkiw et al, 2019Unilateral MFB Eskow Jaunarajs et al, 2010 Unilateral MFB Sarizotan Zhang et al, 2011 Unilateral MFB 5-HT 1A , 5-HT 6 agonist; 5-HT 7 agonist or antagonist Hui et al, 2014;Liu et al, 2015;Zhang et al, 2015 Unilateral SNc Muscimol Unilateral SNc 5-HT 7 antagonist Han et al, 2015Han et al, , 2016 Unilateral SNc and VTA Citalopram, L-DOPA Winter et al, 2007 MPTP-intoxicated mice Vuckovic et al, 2008 L-DOPA andD2 agonist Mori et al, 2005 MPTP-intoxicated rats Bilateral SNc Santiago et al, 2010 D3 dopamine receptor knockout mice Moraga-Amaro et al, 2014 Engrailed1 heterozygote mice Le Pen et al, 2008 Human α-synuclein overexpressing rats Bilateral SNc Caudal et al, 2015 MitoPark mice Cong et al, 2016 VMAT2 low expression mice Taylor et al, 2009 Anxiety-like 6-OHDA-lesioned mice Bila...…”

A Multi-Gene Synaptic Plasticity Array Identifies Candidate Molecular Underpinnings of Cognitive and Mood Deficits in Rats with Heart Failure

“…SPT relies on the natural preference of rodents for sweet foods and solutions; a decreased preference for a sweet solution versus tap water is assumed to reflect depression-like behavior (Krishnan & Nestler, 2011;Liu et al, 2018). Manipulations that impair DH or PFC function attenuate sucrose preference (Banasr & Duman, 2008;Liu et al, 2015;Kabir et al, 2017), which is consistent with evidence indicating that damage to these areas produces depression in humans (Almeida et al, 2012;O'Donnell et al, 2012). SPT was assessed in home cages with continuous ad libitum access to standard chow.…”