Serotonine and Suicide: A Preliminary Study Concerning a Sample of Violent Suicidal Patients

Cremniter, D.; Thenault, M; Jamain, S; Delmas, C.; Guerin, A.; Gaillard, M.J.

doi:10.1097/00002826-199202001-01148

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“…Since serotonergic neurones act to suppress REM sleep, reduced serotonergic function in schizophrenia could explain the association between suicidal behaviour and REM time/activity observed in the present study. Serotonergic hypoactivity has been specifically implicated in violent suicide attempts (29,30). However, we observed no significant difference between violent and non-violent suicide attempters in our sample of schizophrenic patients.…”

Section: Discussioncontrasting

confidence: 71%

Biological predictors of suicidality in schizophrenia

Lewis¹,

Tandon²,

Shipley³

et al. 1995

Biological Psychiatry

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The objective of this study was to determine whether polysomnographic rapid eye movement (REM) sleep abnormalities and cortisol response to the dcxamcthasone suppression test (DST) differentiate between schizophrenic patients with and without a history of suicidal behaviour. We assessed a sample of 96 schizophrenic in-patients at the end of a 2-week medication-free period with the DST, polysomnography, and an extensive clinical assessment battery. Patients exhibiting suicidal behaviour were significantly more likely to have increased total REM time and increased total REM activity. We found no significant relationship between suicidal bchaviour and DST non-suppression. This study confirms a previous finding suggesting an association between REM sleep abnormalities and suicidal bchaviour in Schizophrenia. It is postulated that this observed association may be related to serotonergic dysfunction in schizophrenia.

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Section: Discussioncontrasting

confidence: 71%