Serotype analysis of pediatric enteroviral meningitis in Gwangju, Republic of Korea: Number of annual cases, distribution by age group, and characteristics of each serotype

Lee, Sanghoon; Yang, Jae Hyuk; Lee, Jieun; Kim, Young Ok

doi:10.1016/j.jcv.2022.105192

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…However, numerous studies corroborate the occurrence of various complications in CVB1-infected HFMD patients, including viral meningitis, viral myocarditis, viral hepatitis, type I diabetes, acute delayed disease, and multiorgan damage. [27][28][29][30][31][32][33][34][35][36] Consequently, CVB1 infection during the acute phase may initially present only with the fundamental clinical symptoms of HFMD. Second, our long-term observations post-CVB1 infection revealed that viral shedding was sustained for up to 21 d.p.i.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of clinical cases of CVB1 are typified by HFMD symptoms. However, numerous studies corroborate the occurrence of various complications in CVB1‐infected HFMD patients, including viral meningitis, viral myocarditis, viral hepatitis, type I diabetes, acute delayed disease, and multiorgan damage 27–36 . Consequently, CVB1 infection during the acute phase may initially present only with the fundamental clinical symptoms of HFMD.…”

Section: Discussionmentioning

confidence: 99%

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A 3‐month‐old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism

Suqin,

Yongjie,

Wei

et al. 2024

Journal of Medical Virology

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Coxsackievirus B1 (CVB1), an enterovirus with multiple clinical presentations, has been associated with potential long‐term consequences, including hand, foot, and mouth disease (HFMD), in some patients. However, the related animal models, transmission dynamics, and long‐term tissue tropism of CVB1 have not been systematically characterized. In this study, we established a model of CVB1 respiratory infection in rhesus macaques and evaluated the clinical symptoms, viral load, and immune levels during the acute phase (0–14 days) and long‐term recovery phase (15–30 days). We also investigated the distribution, viral clearance, and pathology during the long‐term recovery period using 35 postmortem rhesus macaque tissue samples collected at 30 days postinfection (d.p.i.). The results showed that the infected rhesus macaques were susceptible to CVB1 and exhibited HFMD symptoms, viral clearance, altered cytokine levels, and the presence of neutralizing antibodies. Autopsy revealed positive viral loads in the heart, spleen, pancreas, soft palate, and olfactory bulb tissues. HE staining demonstrated pathological damage to the liver, spleen, lung, soft palate, and tracheal epithelium. At 30 d.p.i., viral antigens were detected in visceral, immune, respiratory, and muscle tissues but not in intestinal or neural tissues. Brain tissue examination revealed viral meningitis‐like changes, and CVB1 antigen expression was detected in occipital, pontine, cerebellar, and spinal cord tissues at 30 d.p.i. This study provides the first insights into CVB1 pathogenesis in a nonhuman primate model of HFMD and confirms that CVB1 exhibits tissue tropism following long‐term infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A 3‐month‐old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism

Suqin,

Yongjie,

Wei

et al. 2024

Journal of Medical Virology

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“…In China, since hand, foot, and mouth disease (HFMD) was classified as a Class C statutory infectious disease in May 2008, CVB1 is frequently detected in HFMD outbreaks or sporadically (Guan et al, 2015 ; Chen et al, 2019 ; Ji et al, 2019 ). Except for HFMD, CVB1 also causes life-threatening infections, such as encephalitis (Jain et al, 2014 ), myocarditis (Verma et al, 2009 ), aseptic meningitis (Lee et al, 2022 ), and necrotizing hepatitis (Wong et al, 1989 ; Wang et al, 1998 ), and CVB1 can even cause death (Wikswo et al, 2009 ). CVB1 has also been confirmed to be associated with type 1 diabetes (T1DM) (Oikarinen et al, 2014 ; Sioofy-Khojine et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Screening of a new candidate coxsackievirus B1 vaccine strain based on its biological characteristics

Zhang

Liu

et al. 2023

Front. Microbiol.

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Coxsackievirus B1 (CVB1) is one of the significant pathogens causing viral myocarditis, hand, foot, and mouth disease (HFMD), and aseptic meningitis, and it has been associated with type 1 diabetes (T1DM). No effective antiviral drugs against CVB1 infection or preventive vaccines are available. Due to the success of two inactivated vaccines against enterovirus 71 and poliovirus, an inactivated Vero cell-based CVB1 vaccine could be developed. In this study, we isolated a high-growth CVB1 virus strain KM7 in Vero cells and developed a Vero-adapted vaccine candidate strain KM7-X29 via three rounds of plaque purification and serial passages. The KM7-X29 strain was grouped into the GII sub-genotype, which belonged to the Chinese epidemic strain and grew to a titer of more than 107 CCID50/ml in Vero cells. The inactivated CVB1 vaccine produced by the KM7-X29 strain induced an effective neutralizing antibody response in BALB/c mice, and maternal antibodies were able to provide a 100% protective effect against lethal challenges with a CVB1 strain in suckling BALB/c mice. Thus, the KM7-X29 strain might be used as a new candidate coxsackievirus B1 vaccine strain. The neonatal murine model of CVB1 infection will contribute to the development of the CVB1 vaccine.

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Serotype analysis of pediatric enteroviral meningitis in Gwangju, Republic of Korea: Number of annual cases, distribution by age group, and characteristics of each serotype

Cited by 2 publications

References 28 publications

A 3‐month‐old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism

A 3‐month‐old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism

Screening of a new candidate coxsackievirus B1 vaccine strain based on its biological characteristics

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