Serotype- and virulence-associated gene profile of &lt;i&gt;Streptococcus suis&lt;/i&gt; isolates from pig carcasses in Chiang Mai Province, Northern Thailand

Wongsawan, Kanruethai; Gottschalk, Marcelo; Tharavichitkul, Prasit

doi:10.1292/jvms.14-0380

Cited by 15 publications

(13 citation statements)

References 30 publications

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“…Two studies were carried out in Chiang Mai, northern Thailand. The first study showed that in samples from the submaxillary gland of pig carcasses, serotype 3 was the most prevalent (17.5%), followed by serotypes 2 (12.5%) and 4 (10%) [26]. In the second study, Padungtod et al reported that serotypes 2 (43%) and 7 (14.3%) were more prevalent in healthy pigs than diseased pigs [27].…”

Section: Discussionmentioning

confidence: 99%

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

et al. 2020

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Streptococcus suis is a zoonotic pathogen of economic significance to the swine industry. The number of infected cases is increasing in humans worldwide. In this study, we determined the prevalence and diversity of S. suis carriage in slaughterhouse pigs in Phayao province, Thailand, where an outbreak occurred in 2007. The overall S. suis carriage rate was 35.2% among slaughterhouse pigs. The prevalence rates of serotypes 2 and 14 (the major serotypes infected in humans) were 6.7% and 2.6%, respectively. In both serotypes, 70.4% of isolates of serotypes 2 and 14 revealed sequence types and pulsotypes identical to human isolates in Thailand. It is suggested that pathogenic strains of S. suis are a risk factor for occupational exposure to pigs or the consumption of raw pork products. Food safety, hygiene, and health education should be encouraged to reduce the risk group.

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Section: Discussionmentioning

confidence: 99%

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

et al. 2020

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“…As thiol-activated hemolysin may be associated with the ability of the bacteria to penetrate into deeper tissues, isolates from the lungs might be less capable of penetrating different organs and is not considered a primary agent of pneumonia [6, 22]. The virulence-associated gene distribution patterns of Korean isolates were similar to those of North American isolates in 2003–2005 and Northern Thailand isolates in 2001–2002 [7, 43]: epf − / mrp + / sly − (35.4%) was the most prevalent, followed by epf − / mrp − / sly + (20.0%) and epf − / mrp + / sly + (16.3%). Therefore, overall, the virulence-associated gene distribution in the present study can be characterized by the high prevalence of mrp and low epf prevalence.…”

Section: Discussionmentioning

confidence: 99%

“…Many factors have been suggested to contribute to the virulence of S. suis ; however, most of the studies conducted thus far have focused on identification of the following three factors: muraminidase-released protein (MRP), extracellular protein factor (EF) and suilysin (SLY) [7, 33, 43]. MRP and EF are suspected to be associated with virulence in certain strains of S. suis [42, 45].…”

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Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of <i>Streptococcus suis</i> isolates from pigs in Korea

Jeon

Jung

et al. 2017

The Journal of Veterinary Medical Science

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Streptococcus suis is an important pig pathogen with potential for human transmission. The serotype distributions and phenotypic characteristics vary over time and among regions; however, little is known about the characteristics of S. suis isolates in Korea. In this study, 240 S. suis isolates collected from pigs in Korea in 2009–2010 were serotyped by coagglutination tests, subsequently screened for three virulence-associated genes (mrp, epf and sly) and tested for antimicrobial susceptibility. As for 80 isolates, the serotypes of which were relevant to human infections, clonal complexes (CCs) were further identified by PCR. Serotype 3 was the most prevalent (15.8%), followed by serotype 2 (15.0%), with geographical variation for each serotype. Overall, 55.4% of the isolates carried mrp, whereas only 3.8% carried epf. CC25 was the most prevalent (41.3%) and was related to serotypes 2 and 9. The isolates showed higher susceptibility to ampicillin (93.4%) and ceftiofur (90.8%) than to the other antimicrobial agents tested. The highest resistance rate was observed to tetracycline (98.0%), followed by erythromycin (88.8%). In addition, the resistance to certain antimicrobials was significantly associated, in part, with virulence-associated genes or serotypes. Therefore, continuous characterization of S. suis is essential for the benefit of veterinary and human medicine.

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“…Thirty-seven percent of the isolates was nontypable by multiplex PCR ( Thongkamkoon et al, 2017 ). Another study from Northern Thailand (Chiang Mai Province) found mostly serotype 3 isolates in submaxillary glands of pig carcasses sold in wet markets ( Wongsawan et al, 2015 ). A further study investigated samples from asymptomatic pigs from central Thailand and found mainly serotype 16 strains ( Meekhanon et al, 2017 ).…”

Section: Diversity Of S Suismentioning

confidence: 99%

Streptococcus suis – The “Two Faces” of a Pathobiont in the Porcine Respiratory Tract

et al. 2018

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Streptococcus (S.) suis is a frequent early colonizer of the upper respiratory tract of pigs. In fact, it is difficult to find S. suis-free animals under natural conditions, showing the successful adaptation of this pathogen to its porcine reservoir host. On the other hand, S. suis can cause life-threatening diseases and represents the most important bacterial cause of meningitis in pigs worldwide. Notably, S. suis can also cause zoonotic infections, such as meningitis, septicemia, endocarditis, and other diseases in humans. In Asia, it is classified as an emerging zoonotic pathogen and currently considered as one of the most important causes of bacterial meningitis in adults. The “two faces” of S. suis, one of a colonizing microbe and the other of a highly invasive pathogen, have raised many questions concerning the interpretation of diagnostic detection and the definition of virulence. Thus, one major research challenge is the identification of virulence-markers which allow differentiation of commensal and virulent strains. This is complicated by the high phenotypic and genotypic diversity of S. suis, as reflected by the occurrence of (at least) 33 capsular serotypes. In this review, we present current knowledge in the context of S. suis as a highly diverse pathobiont in the porcine respiratory tract that can exploit disrupted host homeostasis to flourish and promote inflammatory processes and invasive diseases in pigs and humans.

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Serotype- and virulence-associated gene profile of <i>Streptococcus suis</i> isolates from pig carcasses in Chiang Mai Province, Northern Thailand

Cited by 15 publications

References 30 publications

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of <i>Streptococcus suis</i> isolates from pigs in Korea

Streptococcus suis – The “Two Faces” of a Pathobiont in the Porcine Respiratory Tract

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