Serotype influences on dengue severity: a cross-sectional study on 485 confirmed dengue cases in Vitória, Brazil

Vicente, Creuza Rachel; Herbinger, Karl‐Heinz; Fröschl, Günter; Romano, Camila Malta; Cabidelle, Aline de Souza Areias; Cerutti, Crispim

doi:10.1186/s12879-016-1668-y

Cited by 106 publications

(83 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the patients, 30.7% showed improved management of DF diagnosis and treatment. The indings of the present study are also lower than those derived in research in Brazil (i.e., 6.5%) (Vicente et al, 2016).…”

Section: The Relationship Between Subclinical Characteristics and Dencontrasting

confidence: 83%

The correlation of clinical and subclinical presentations with dengue serotypes and plasma viral load: the case of children with dengue hemorrhagic fever in Vietnam

Tran

et al. 2019

ijrps

View full text Add to dashboard Cite

Numerous studies have been carried out on patients afflicted with dengue hemorrhagic fever (DHF), but various issues related to the disease, including the characteristics of the dengue virus (DENV), remain unclear. To address this deficiency, the current research was conducted to determine the correlation of clinical and subclinical presentations with dengue serotypes and plasma viral load. This prospective cohort study, which was performed at Tien Giang General Hospital from 2009 to 2014, involved 481 children who were under 15 years of age and had DHF for less than 72 hours. Results showed that among the patients, the highest proportion were composed of those suffering from DENV-1 infection (44.7%). The progression of the disease to dengue shock syndrome (DSS) owing to infection with DENV-2 and DENV-1 was significantly higher than that caused by infection with DENV-3 and DENV-4. No statistically significant differences in DENV viremia were found between the non-shock DHF and DSS groups. Finally, no correlation was found between dengue plasma viral load and clinical and subclinical presentations. The findings led to the conclusion that dengue serotypes can be used as a basis in ascertaining the prognosis of DSS and DHF.

show abstract

Section: The Relationship Between Subclinical Characteristics and Dencontrasting

confidence: 83%

The correlation of clinical and subclinical presentations with dengue serotypes and plasma viral load: the case of children with dengue hemorrhagic fever in Vietnam

Tran

et al. 2019

ijrps

View full text Add to dashboard Cite

show abstract

“…methods such as detecting SNVs in RNA or compatibility with isothermal amplification of substrate 29 . At the level of RNA, by appending a Reverse Transcription (RT) step prior to amplification, we could successfully distinguish two Dengue virus serotypes (West Pac/74 and P23085, designated 1 and 2) that lead to variable mortality rates in patients (Supplementary Figure 6) 30,31 . To circumvent the need of complex instrumentation for preamplification, we optimized Recombinase Polymerase Amplification (RPA) for generating amplicons that can contribute to a field deployable assay prototype (Supplementary Figure 7A-B) 32 .…”

Section: Feluda Detection Can Be Customized With Other Features Of Cumentioning

confidence: 99%

Rapid, field-deployable nucleobase detection and identification using FnCas9

Azhar

Phutela

Ansari

et al. 2020

Preprint

View full text Add to dashboard Cite

Detection of pathogenic sequences or variants inDNA and RNA through a point-of-care diagnostic approach is valuable for rapid clinical prognosis. In recent times, CRISPR based detection of nucleic acids has provided an economical and quicker alternative to sequencing-based platforms which are often difficult to implement in the field. Here, we present FnCas9 Editor Linked Uniform Detection Assay (FELUDA) that employs a highly accurate enzymatic readout for detecting nucleotide sequences, identifying nucleobase identity and inferring zygosity with precision. We demonstrate that FELUDA output can be adapted to multiple signal detection platforms and can be quickly designed and deployed for versatile applications including rapid diagnosis during infectious disease outbreaks like COVID-19.

show abstract

“…Once the biological prognostic markers for severe dengue fever are identified, their validation will require large and independent cohorts of dengue patients who differ in ages and immune status. Regarding the pathogenic properties of DENV, it has been widely reported that DENV-2 infection causes a greater number of severe cases than other serotypes [22].…”

Section: Asymptomatic and Symptomatic Cases Of Denguementioning

confidence: 99%

Dengue: a growing threat requiring vaccine development for disease prevention

Bos

Gadéa

Desprès

2018

Pathogens and Global Health

View full text Add to dashboard Cite

Dengue disease is the most prevalent mosquito-borne viral infection in humans. At least one half of the global population is estimated at risk of infection and an estimated 390 million people are infected each year. Over the past few years, dengue burden continued to increase, mainly impacting developing countries. Alarming changes in dengue epidemiology were observed highlighting a spread from tropical to subtropical regions as well as urban to rural areas. An increase in the co-infections with the four serotypes has also been noticed, involving a shift in the targeted population from pediatric to adult. Facing these global changes, authorities will have to reinforce preventive actions and adapt healthcare management. New prophylactic strategies are urgently needed to prevent severe forms of dengue disease. The lack of specific antiviral therapies available turns vaccine development into a socio-economic challenge. In this review, we propose an update on the dengue global trends and different vaccine strategies in development. A particular attention will be paid to up-to-date information on dengue transmission and the protective efficacy of newly commercialized tetravalent dengue vaccine Dengvaxia®, as well as the most advanced candidate vaccines in clinical development.

show abstract

Serotype influences on dengue severity: a cross-sectional study on 485 confirmed dengue cases in Vitória, Brazil

Cited by 106 publications

References 29 publications

The correlation of clinical and subclinical presentations with dengue serotypes and plasma viral load: the case of children with dengue hemorrhagic fever in Vietnam

The correlation of clinical and subclinical presentations with dengue serotypes and plasma viral load: the case of children with dengue hemorrhagic fever in Vietnam

Rapid, field-deployable nucleobase detection and identification using FnCas9

Dengue: a growing threat requiring vaccine development for disease prevention

Contact Info

Product

Resources

About