Serous adenocarcinoma of retroperitoneum: a case report

Kohada, Yuki; Teishima, Jun; Hattori, Yui; Kurimura, Yoshimasa; Fujii, Shinsuke; Sadahide, Kousuke; Fukuoka, Kenichiro; Ueno, Takeshi; Kohno, Hiroyuki; Goto, Keisuke; Hieda, Keisuke; Shinmei, Shunsuke; Sentani, Kazuhiro; Inoue, Shogo; Hayashi, Tetsutaro; Yasui, Wataru; Matsubara, Akio

doi:10.1007/s13691-017-0296-8

Cited by 6 publications

(9 citation statements)

References 14 publications

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“…PRSA is an epithelial tumor bearing histological resemblance with ovarian serous carcinoma. To date, there have been eight reported cases of PRSA, all of which were in females [1–8]. We describe the first case of PRSA in a male.…”

Section: Discussionmentioning

confidence: 96%

“…The common histological patterns include fibrosarcoma, lymphoma and teratoma. [8] The epithelial subtype is the least prevalent of all. PRSA is an epithelial tumor bearing histological resemblance with ovarian serous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…It has been advocated that adjuvant chemotherapy with carboplatin alongside docetaxel or paclitaxel be given following surgery in patients with risk factors for recurrence [4]. Although surgical resection of tumor with adjuvant chemotherapy is accepted as an appropriate treatment for PRSA [6–8], definitive guidelines cannot be established.…”

Section: Discussionmentioning

confidence: 99%

“…Out of the eight cases previously described in literature, one patient received upfront chemotherapy with carboplatin and cyclophosphamide as the first line treatment and underwent a partial response [3]. Two patients underwent surgical resection followed by chemotherapy and were in remission after 6 and 21 months of primary treatment, respectively [6, 8]. However, in three other cases, no response was shown; these patients were then subjected to additional chemotherapy but none of them exhibited complete response [4, 5, 7].…”

Section: Discussionmentioning

confidence: 99%

“…Primary retroperitoneal serous adenocarcinoma (PRSA) is a rare clinical entity. To date, a handful of cases have been reported all of which occurring in female patients [1–8]. While there have been some reports of mucinous subtype of retroperitoneal adenocarcinoma in males [9, 10], no case of serous subtype has been presented in this subgroup to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Exceptional response to chemotherapy followed by concurrent radiotherapy and immunotherapy in a male with primary retroperitoneal serous Adenocarcinoma: a case report and literature review

et al. 2019

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Background Primary retroperitoneal serous adenocarcinoma (PRSA) is an extremely uncommon malignancy exclusively reported in females. Due to the rarity of the disease, it is difficult to establish a standardized treatment. Case presentation We describe a unique case of PRSA in a 71-year-old male who presented with right-sided lower back pain and numbness. Magnetic resonance imaging identified a mass invading the adjacent psoas muscle and twelfth rib. Tissue biopsy confirmed poorly differentiated PRSA. Patient was initially treated with neoadjuvant carboplatin and paclitaxel chemotherapy regimen. This resulted in complete radiological resolution of the tumor. However, 12 weeks later, rapid recurrence was noted on follow-up CT scan. The patient was then treated with external radiotherapy with concurrent nivolumab, an anti-PD-1 antibody. The patient displayed a positive response to treatment with reduction in primary tumor and metastases and had a sustained disease control. Conclusion Treatment with radiotherapy in combination with anti-PD-1 antibody could be an effective modality of management for PRSA. Electronic supplementary material The online version of this article (10.1186/s12885-019-5934-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exceptional response to chemotherapy followed by concurrent radiotherapy and immunotherapy in a male with primary retroperitoneal serous Adenocarcinoma: a case report and literature review

et al. 2019

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FDG PET/CT in Primary Retroperitoneal Serous Carcinoma

Otsuka¹,

Honma

2023

Clin Nucl Med

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Primary retroperitoneal tumors are rare. Of these, primary retroperitoneal serous carcinoma is extremely rare, with only 15 cases having been reported. A 62-year-old woman presented with abdominal bloating. PET/CT demonstrated 2 tumors showing increased FDG uptake lateral and medial to the right common iliac vessels, without other abnormal uptake. A laparotomy revealed no ascites or abnormalities except a myomatous uterus in the peritoneal cavity. After surgical removal of these retroperitoneal tumors, the patient received adjuvant paclitaxel/carboplatin chemotherapy and remained well for 80 months. This case points to the significance of 18 F-FDG PET/CT in determining the nature of retroperitoneal tumors.

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Added value of contrast-enhanced ultrasound (CEUS) in the diagnosis of primary retroperitoneal serous adenocarcinoma: a case report

et al. 2021

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Background Primary retroperitoneal serous adenocarcinoma (PRSA) is a rare malignant disease. Given the rarity of the disease, the imaging features of PRSA are unclear. Contrast-enhanced ultrasound (CEUS) also plays an important role in the evaluation of the differential diagnosis of retroperitoneal lesions. Case presentation We report the case of a 62-year-old woman of with increased CA125 levels for 1 year who was referred to our hospital. After conducting contrast-enhanced computed tomography and magnetic resonance imaging, the mass was misdiagnosed as a chocolate cyst. After transvaginal ultrasound (TUS) combined with CEUS, cystadenocarcinoma was considered as the initial diagnosis. Pathology results confirmed PRSA as the final diagnosis. Conclusions CEUS features of PRSA are reported for the first time based on this case, potentially aiding in the differential diagnosis of this rare entity before surgery.

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Serous adenocarcinoma of retroperitoneum: a case report

Cited by 6 publications

References 14 publications

Exceptional response to chemotherapy followed by concurrent radiotherapy and immunotherapy in a male with primary retroperitoneal serous Adenocarcinoma: a case report and literature review

Exceptional response to chemotherapy followed by concurrent radiotherapy and immunotherapy in a male with primary retroperitoneal serous Adenocarcinoma: a case report and literature review

FDG PET/CT in Primary Retroperitoneal Serous Carcinoma

Added value of contrast-enhanced ultrasound (CEUS) in the diagnosis of primary retroperitoneal serous adenocarcinoma: a case report

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