Serous Carcinoma of the Testicle and the Paratesticular Tissue: Case Report and Literature Review

Pease, Garrison; Chou, Pauline M.

doi:10.1016/j.urology.2017.05.039

Cited by 4 publications

(11 citation statements)

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“…Most cases are cytokeratin (CK)7-positive, and CK20negative, and also display expression of other epithelial markers, including CAM5.2, AE1/AE3, Ber-EP4, and MOC-31 [6,36]. In addition, consistent positivity for markers of Mullerian differentiation, such as PAX-8, WT-1, estrogen receptor (ER), progesterone receptor (PR), and CA-125, has been observed [5,18]. Some cases also exhibit reactivity to CA19-9, carcinoembryonic antigen (CEA), S100, and Leu-M1 (CD15) [19,20].…”

Section: Serous Tumorsmentioning

confidence: 96%

“…Serous tumors, comprising benign serous cystadenomas, serous borderline tumors (SBTs), and serous carcinomas, are the most common ovarian-type neoplasm arising in the testicular region, with approximately 60 cases reported in the literature thus far [1,[4][5][6]. The location of the mass may be either intratesticular or paratesticular.…”

Section: Serous Tumorsmentioning

confidence: 99%

“…SBTs may be either solid, cystic, or have components of both, often with papillary excrescences arising from the cyst wall [4,6]. In contrast, serous carcinomas are usually solid, ill-defined masses, sometimes with a characteristic gritty quality due to calcifications [3,5].…”

Section: Serous Tumorsmentioning

confidence: 99%

“…Some cases also exhibit reactivity to CA19-9, carcinoembryonic antigen (CEA), S100, and Leu-M1 (CD15) [19,20]. However, in all cases authors reported negative staining for mesothelial markers (such as calretinin, D2-40, and thrombomodulin), mesonephric markers (such as GATA3 and CD10), and germ cell markers (such as OCT4 and placental alkaline phosphatase [PLAP]) [5,20]. Ki-67 proliferation index has been reported as less than 1% in serous cystadenoma, 5.5% in serous borderline tumor, and up to 80-85% in serous carcinoma [6,10,38].…”

Section: Serous Tumorsmentioning

confidence: 99%

“…While benign and borderline tumors generally remain localized, malignant tumors are capable of distant metastasis. Commonly reported metastatic sites include lymph nodes, peritoneum, and lungs [5]. The pathogenesis of ovarian-type epithelial tumors of the testis is still not fully understood, and several theories have been proposed for their histologic origin.…”

Section: Introductionmentioning

confidence: 99%

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Ovarian-type Tumors (Mullerian Tumors) of the Testis: Clinicopathologic Findings with Recent Advances

Lin

Ayala

2019

ann urol oncol

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Ovarian-type epithelial tumors rarely occur in the human testis and paratesticular region. Histologically, these tumors closely resemble their ovarian counterparts and are therefore classified similarly to ovarian epithelial tumors. Most reported ovarian-type tumor cases are serous tumors, but the full spectrum of ovarian neoplasms has been described, including mucinous, endometrioid, clear cell, and Brenner tumors. In this review, we describe the clinical, morphologic, and immunohistochemical features of Mullerian-type epithelial tumors seen in the testis, with an emphasis on comparison with ovarian tumors. We also discuss theories of pathogenesis, considerations in the differential diagnosis, and recent advances in molecular characterization and therapeutic modalities.

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