Serous cystadenocarcinoma of the spleen

Abstract

The commonly seen primary malignant neoplasms of the spleen are angiosarcoma and lymphoma. We present a case of serous cystadenocarcinoma of the spleen. It was presumed to be originated from dropped nonmalignant ovarian tissue, which was accidentally implanted to the splenic surface during hysterectomy and bilateral salpingooophorectomies for torsion of right fallopian tube 9 and half years ago and transformed into serous cystadenocarcinoma later. Computed tomography demonstrated a multilocular predominantly cystic tumor with internal soft tissue components in the spleen.

A unique case of splenic tumor exhibiting a serous carcinoma phenotype

“… 7 , 8 However, the origin of splenic serous carcinoma remains unknown. 6 In our case, metastasis from latent serous tubal intraepithelial carcinoma could not be ruled out, but it was possible that the tumor developed from an ectopic fallopian tube-like epithelium, that is, endosalpingiosis. Endosalpingiosis is a müllerianosis and is frequently observed in organs such as the lymph nodes, ovaries, or peritoneum where müllerian epithelium is normally absent.…”

“…Primary serous carcinomas of the spleen are extremely rare, and we could find only one reported case. 6 Serous tubal intraepithelial carcinoma is the plausible origin of most pelvic serous carcinomas. 7 , 8 However, the origin of splenic serous carcinoma remains unknown.…”

“… 10 – 12 According to some reports, mesothelial cells have the potential to differentiate into fallopian tube-like epithelium, and splenic endosalpingiosis arises from the invaginated splenic capsule or peritoneum. 6 , 10 , 12 Another hypothesis is that aberrant remnants of the proximal portion of the müllerian ducts develop into fallopian tube-like epithelium. 9 , 10 The term “secondary müllerian system” is used to explain these theories, 9 , 10 but the mechanism remains unproven.…”

Isolated splenic high-grade serous carcinoma: A case report

“…Primary neoplasms of the spleen are rare and are typically lymphomas, angiosarcomas, hemangiomas, or hamartomas ( Chou and Chou, 2017 ). A prior case of isolated serous carcinoma was described by Chou et al The authors theorized that non-malignant tissue from either the ovary, stomach, colon, or pancreas was incidentally implanted on the spleen during a total abdominal hysterectomy/bilateral salpingo-oophorectomy 9.5 years earlier after torsion of the right fallopian tube ( Chou and Chou, 2017 ). Here, we present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor in the ovary, fallopian tubes, omentum, or uterus.…”

Primary Splenic Melanoma Associated with Small Intestinal Serosal Implants Causing Intussusception - A Case Report

“…Lymphoid tumors include Non-Hodgkin's lymphoma, Hodgkin's disease, plasmacytoma, localized lymphoid hyperplasia, Castleman's tumor, and inflammatory pseudotumor. Vascular tumors include malignant lesions such as hemangiosarcoma -which arises from the vascular endothelial cells-, borderline lesions such as hemangiopericytoma, hemangioendothelioma and littoral cell angioma as well as benign lesions such as hemangioma -which is the most common one-, lymphangioma and hamartoma (4-8) Primary mucinous and serous cystadenocarcinoma as well as pleomorphic carcinosarcoma have been reported(9)(10)(11).…”