Serratia marcescens

Hejazi, A.; Falkiner, FrederickR.

doi:10.1099/00222615-46-11-903

Cited by 517 publications

(423 citation statements)

References 31 publications

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“…In 2007, Shanks et al demonstrated the role of oxyR and type I fimbrial genes and concluded that they are involved in cell-cell and cell-biotic surface interactions. In addition, two classes of pili, mannose-resistant and mannose-sensitive pili may also play a role in the attachment of bacteria to epithelial cells [67].…”

Section: Adhesionmentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

181

121

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Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for causing ocular disease. Clinical features include redness, pain, tearing, blur vision and inflammation but symptoms vary depending on the causative agent. The underlying molecular mechanisms associated with microbial pathogenesis include virulence factors as well as the host factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The treatment therefore should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the rational development of therapeutic interventions. This is a timely review of our current understanding of the advances made in this field in a comprehensible manner. Coupled with the recently available genome sequence information and high throughput genomics technology, and the availability of innovative approaches, this will stimulate interest in this field.

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Section: Adhesionmentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

181

121

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“…marcescens is a known nosocomial pathogen and can cause a variety of infections in humans including blindness in the susceptible host [17,20,52]. It is thus important to understand its proliferative mechanisms in relation to its existence in the DUWL environment to inform the future development of disinfection regimes.…”

Section: Vermiformis Dominates the Duwl Environment [7] And Their mentioning

confidence: 99%

“…marcescens is known to be a nosocomial pathogen which can acquire antimicrobial resistance [27]. This bacterium can cause a variety of infections in the susceptible host including septicaemia, meningitis, endocarditis and blindness [17,20,52]. Previous work from our laboratory on grazing habits of V. vermiformis [14] indicated that small sized bacteria were favoured as a food source.…”

mentioning

confidence: 99%

Risk Assessment for the Spread of Serratia marcescens Within Dental-Unit Waterline Systems Using Vermamoeba vermiformis

et al. 2015

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(2015) Risk assessment for the spread of Serratia marcescens within dental unit waterline systems using Vermamoeba vermiformis. Current Microbiology, 71 (4). pp. 434 442.It is advisable to refer to the publisher's version if you intend to cite from the work.http://dx.doi.org/10.1007/s00284-015-0872-0For more information about UCLan's research in this area go to http://www.uclan.ac.uk/researchgroups/ and search for . Conflict of interest disclosure statementAll named authors declare that there is no conflict of interest.2 Title: Risk assessment for the spread of Serratia marcescens within dental-unit waterline systems using Vermamoeba vermiformis Abstract:Vermamoeba vermiformis is associated with the biofilm ecology of dental-unit waterlines (DUWLs). This study investigated whether V. vermiformis is able to act as a vector for potentially pathogenic bacteria and so aid their dispersal within DUWL systems. Clinical dental water was initially examined for Legionella species by inoculating it onto Legionella selective-medium plates. The molecular identity/profile of the glassy colonies obtained indicated none of these isolates were Legionella species. During this work bacterial colonies were identified as a non-pigmented Serratia marcescens. As the water was from a clinical DUWL which had been treated with Alpron™ this prompted the question as to whether S. marcescens had developed resistance to the biocide. Exposure to Alpron™ indicated that this dental biocide was effective, under laboratory conditions, against S. marcescens at up to 1x10 8 colony forming units/millilitre (cfu/ml). V. vermiformis was cultured for eight weeks on cells of S. marcescens and Escherichia coli. Subsequent electron microscopy showed that V.vermiformis grew equally well on S. marcescens and E. coli (p = 0.0001). Failure to detect the presence of S.marcescens within the encysted amoebae suggests that V. vermiformis is unlikely to act as a vector supporting the growth of this newly isolated, nosocomial bacterium.

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“…Among enteric bacteria, S. marcescens is unique, because it secretes extracellular enzymes (e.g., chitinase, DNase, lipase, protease), produces red pigment prodigiosin and surfactant serrawettin used in the surfaces colonization 1 . Carotenoid pigments (e.g., β-carotene) are produced also in S. marcescens 2 , and the pigment biosynthesis acts as a protective mechanism in unfavorable conditions 1 . Bacterial strains living in the polluted environments must cope with the toxic compounds (e.g., organic solvents) which result from humans activity.…”

Section: Introductionmentioning

confidence: 99%