Serratia marcescens bacteremia cases: A pseudo-outbreak experience

Mumcuoğlu, İpek; Kanyılmaz, Dilek; Yetkin, Meltem Arzu; Cetin, Feyza; Özmen, Büşra Betül; Karahan, Zeynep Ceren; Baran, İrmak; Kayaaslan, Bircan; Bodur, Hürrem; Aksu, Neriman

doi:10.1016/j.ajic.2016.01.029

Cited by 4 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the superbug E. coli bacteria with mcr‐1 gene is resistant to colistin, an antibiotic which is the last choice for treating multidrug‐resistant (MDR) bacterial infections . The increasing emergence of MDR bacteria not only caused the failure of antibiotic treatment but also aggravated the economic burden of the patients due to the prolonged hospitalizations . Therefore, it is urgent and of great importance to develop novel antibacterial materials for resolving the as‐mentioned issues.…”

Section: Introductionmentioning

confidence: 99%

Dendritic Fe₃O₄@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

et al. 2018

Adv Funct Materials

288

169

View full text Add to dashboard Cite

Nowadays, antibiotic abuse increases the emergence of multidrug-resistant bacterial strains, which is the major reason for the failure of conventional antibiotic therapies. Therefore, developing novel antibacterial materials or therapies is an urgent demand. In the present study, photothermal and NOreleasing properties are integrated into a single nanocomposite to realize more efficient bactericidal effects. To this end, polydopamine (PDA) coated iron oxide nanocomposite (Fe 3 O 4 @PDA) is used as a photoconversion agent and the core, first three generation dendritic poly(amidoamine) (PAMAM-G3) is grafted on the surface of Fe 3 O 4 @PDA, and subsequently NO is loaded with the formation of NONOate. The resultant Fe 3 O 4 @PDA@PAMAM@NONOate displays controllable NO release property under intermittent 808 nm laser irradiation and excellent bacteria-separation efficiency. Moreover, excellent synergistic photothermal and NO antibacterial effects are observed against both Gramnegative Escherichia coli and Gram-positive Staphylococcus aureus, where bacterial viability and biofilm are significantly reduced. An antibacterial mechanism study reveals that the materials first adsorb onto the bacterial membrane, then cause damage to the membrane by the increased local temperature and the released NO under laser irradiation conditions, finally leak the intracellular components like DNA and induce bacteria death. The work provides a novel way for designing of antibacterial materials with higher efficiency.

show abstract

Section: Introductionmentioning

confidence: 99%

Dendritic Fe₃O₄@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

et al. 2018

Adv Funct Materials

288

169

View full text Add to dashboard Cite

show abstract

Chitosan-graft-PAMAM loading nitric oxide for efficient antibacterial application

Wang

et al. 2018

Chemical Engineering Journal

View full text Add to dashboard Cite

Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment

Zhou

Lin

et al. 2021

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Serratia marcescens bacteremia cases: A pseudo-outbreak experience

Abstract: sustainable care and development and nosocomial infection management. The government and the director of the hospital should emphasize the role of rational design of the wards and hospital layout and balance the costs and benefits in prevention of infection.

Cited by 4 publications

References 8 publications

Dendritic Fe₃O₄@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

Dendritic Fe₃O₄@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

Chitosan-graft-PAMAM loading nitric oxide for efficient antibacterial application

Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment

Contact Info

Product

Resources

About

Serratia marcescens bacteremia cases: A pseudo-outbreak experience

Abstract: sustainable care and development and nosocomial infection management. The government and the director of the hospital should emphasize the role of rational design of the wards and hospital layout and balance the costs and benefits in prevention of infection.

Cited by 4 publications

References 8 publications

Dendritic Fe3O4@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

Dendritic Fe3O4@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

Chitosan-graft-PAMAM loading nitric oxide for efficient antibacterial application

Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment

Contact Info

Product

Resources

About

Dendritic Fe₃O₄@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study

Dendritic Fe₃O₄@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study