Serrobiochemical Effects of Potassium Bromate on Wistar Albino Rats

Abuelgasim, Afaf I.; Omer, Rehab; Elmahdi, B.

doi:10.3923/ajft.2008.303.309

Cited by 12 publications

(12 citation statements)

References 12 publications

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“…This result is similar to that obtained by 20,21,5 who reported the hepatocyte degeneration and necrosis in liver, congestion and swelling of tubular cells, as well as congestion and dilation of portal veins. The dilation of these veins observed in the present work is in accord with those presented by 22 Degenerative changes and fenestration of endothelial cells in rats administered of KBrO 3 , may be an indication of the destruction of the capillary endothelium of the liver by the chemical substance 20 . Necrosis is evidenced by nuclear disintegration and increased eosinophilic reaction of the cytoplasm.…”

Section: Discussionsupporting

confidence: 92%

“…The toxic or lethal dose of KBrO 3 in humans has not been accurately established 1 . Administration of KBrO 3 to rats was found to induce oxidative stress and passively impair the antioxidant power of rat blood 2,3 reported that KBrO 3 caused congestion of the central vein with blood cells in the hepatocytes, infiltration of the interstitial cells 4 . indicated that KBrO 3 caused vacuolation, neuronal degeneration and haemorrhage.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological Effects of Potassium Bromate on Liver Male Rat's and Possible Protective Role of Ruta chalepensis L. (Rutacae) Oil Extract

Gheth

Eldurssi

Algassi

et al. 2019

Asian J Pharm Res Dev

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Potassium bromate (KBrO3) is an oxidizing agent that has been used as a food additive, mainly in the bread-making process. Ruta chalepensis L. (Family-Rutaceae) is a small shrub, native to the Mediterranean Basin. The present study aimed to investigate the protective and curative effects of R. chalepensis oil extract against KBrO3 toxicity on liver of male rats. Fifty male albino rats were divided into five groups. The first group served as a control group. The second group was administered Rue at an oral daily dose of 0.5 g/Animal for four weeks. The third group received KBrO3 100 mg/kg/b. w. for four weeks. The fourth group (protective group) was initially administered Rue alone for 2 weeks and followed by KBrO3 in association with Rue for 2 weeks. The fifth group (therapeutic group) was first given KBrO3 alone for 2 weeks and was then administered Rue in association with KBrO3 for 2 weeks. At the end of 2nd and 4th weeks of treatment, the liver tissues were dissected out for histopathological studies. Histopathological sections of rats administered with Rue showed the same histological observations as in the liver of control animals. KBrO3 treated rats exhibited marked congestion and dilatation of the blood vessels, the central veins and the portal veins. Additionally, marked infiltrative inflammatory cells were revealed. The occurrence of the cellular necrobiotic lesions and nuclei in these necrotic cells showed pyknosis. They also, showed cellular atrophied and hyaline degeneration of the cytoplasm. Vacuoles of different shapes and sizes were developed in the hepatocytes. Blood vessels being thick walled and fibrotic encircled by an inflammatory area rich in leucocytes. The protective and therapeutic groups showed marked hepatoprotective activity and better improvement than that noticed in the group which was given KBrO3 only. It may be concluded from the results that the hepatotoxic effect of KBrO3 and the ameliorative effect of Rue an effective when administrated as protective and therapeutic measures. Keywords: Rat, Liver, Potassium Bromate, Ruta chalepensis, Histopathology.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Histopathological Effects of Potassium Bromate on Liver Male Rat's and Possible Protective Role of Ruta chalepensis L. (Rutacae) Oil Extract

Gheth

Eldurssi

Algassi

et al. 2019

Asian J Pharm Res Dev

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“…The same injuries occurred after four weeks, in addition to severe disorganization of kidney, fibrosis tissue bands, desquamated epithelial cells and loss of brush border. Similar results have been reported by 21 Dilatation of tubules with loss of brush border was reported by 22 Degenerative changes in the proximal convoluted tubules reinforce the views of 21,23 where it was found that many chemicals have a direct nephrotoxic action and exerted their effects principally on the proximal convoluted tubule. Hemorrhage and congestion of the blood vessels of the kidneys were seen in the rats fed KBrO 3 .…”

Section: Discussionsupporting

confidence: 87%

Protective Effects of Ruta Chalepensis L. (Rutacae) Oil Extract Against Potassium Bromate Induced Nephrotoxicity in Male Rats: Histopathological Study

Eldurssi

Gheth

et al. 2019

Asian J Pharm Res Dev

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Ruta chalepensis L. (Rutaceae) is a perennial herb, widely distributed in the Mediterranean area, with glabrous stem, alternate bipinnatisect leaves. It is an ancient medicinal plant still being used in the traditional medicine of many countries. Potassium bromate (KBrO3) is a strong oxidizing agent that has been used in flour milling, as a cheese making, in beer malting, as a component of cold hair-wave liquids. This study studies the protective and curative effects of R. chalepensis oil extract against KBrO3 toxicity on kidney of male rats. Accordingly, a total number of fifty male albino rats were divided into five groups. The first group served as a control animals. The second group was administered Rue at an oral daily dose of 0.5 g/Animal for four weeks. The third group received KBrO3 100 mg/kg/b. w. for four weeks. The fourth group (protective group) was initially administered with Rue alone for 2 weeks and followed by KBrO3 in association with Rue for 2 weeks. The fifth group (therapeutic group) was first given KBrO3 alone for 2 weeks and was secondly administered Rue in association with KBrO3 for 2 weeks. At the end of 2nd and 4th weeks of treatment, the kidney tissues were collected for histopathological studies. Histopathological studies revealed that the renal reactions of rats from the Rue group showed normal architecture pattern same that observations as in the control rats. The rats treated with KBrO3 showed vacuolation and contraction of glomerular tuft, separation in intertubular connective tissue, necrotic changes in some areas and hyaline changes in tubules. Furthermore, lymphoid infiltration and intratubular hemorrhage, dilated in tubules with loss of cellular boundary. In the protective group minimal changes in the structure of the kidney was revealed compared to control. Both glomeruli and convoluted tubules gained the normal features. In therapeutic group, renal sections revealed improvement in the histological structure though there was a mild necrosis and slight in inflammatory leucocytic infiltration. The results of this study suggest the nephrotoxic effect of KBrO3 and the ameliorative effect of Rue when administrated for protective and therapeutic purposes.

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“…Concomitantly, KBrO 3 induced pathological changes on the histological level in the brain tissue of the treated rats which may be considered as another important causative factor for the negative behavioral changes. Previous studies have reported hemorrhage, neuronal degeneration and vacuolation of the brain tissue sections of rats after KBrO 3 treatment [ 19 ]. Taken together, our data illustrate that oral administration of KBrO 3 has a direct effect on the behavioral level, neurotransmitters content, antioxidant status and brain histomorphology of white albino rat and that using two different doses of KBrO 3 has different outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that KBrO 3 induces oxidative stress in tissues [ 15 – 18 ] that could be the basis of bromate-induced behavioral changes. Moreover, KBrO 3 induces hemorrhage, neuronal degeneration and vacuolation of the brain tissue sections [ 19 ]. The present study attempts to assess the effect of oral administration of KBrO 3 on the behavioral changes, neurotransmitters, antioxidant status and brain histomorphology of white albino mice using two different doses of KBrO 3 to compare their effects.…”

Section: Introductionmentioning

confidence: 99%

Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice

et al. 2016

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BackgroundPotassium bromate (KBrO3) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO3 administration on the brain functions and behaviour of albino mice.MethodsAnimals were divided into three groups: control, low dose KBrO3 (100 mg/kg/day) and high dose KBrO3 (200 mg/kg/day) groups.ResultsAdministration of KBrO3 led to a significant change in the body weight in the animals of the high dose group in the first, second and the last weeks while water consumption was not significantly changed. Neurobehavioral changes and a reduced Neurotransmitters levels were observed in both KBrO3 groups of mice. Also, the brain level of reduced glutathione (GSH) in KBrO3 receiving animals was decreased. Histological studies favoured these biochemical results showing extensive damage in the histological sections of brain of KBrO3-treated animals.ConclusionsThese results show that KBrO3 has serious damaging effects on the central nervous system and therefore, its use should be avoided.

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Serrobiochemical Effects of Potassium Bromate on Wistar Albino Rats

Cited by 12 publications

References 12 publications

Histopathological Effects of Potassium Bromate on Liver Male Rat's and Possible Protective Role of Ruta chalepensis L. (Rutacae) Oil Extract

Histopathological Effects of Potassium Bromate on Liver Male Rat's and Possible Protective Role of Ruta chalepensis L. (Rutacae) Oil Extract

Protective Effects of Ruta Chalepensis L. (Rutacae) Oil Extract Against Potassium Bromate Induced Nephrotoxicity in Male Rats: Histopathological Study

Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice

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