2012
DOI: 10.1016/j.mee.2012.03.022
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SERS analysis on exosomes using super-hydrophobic surfaces

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Cited by 70 publications
(75 citation statements)
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“…Interestingly, most of these pronounced peaks have previously been identified by others when recording Raman spectra of biological samples like erythrocytes [45] or even EVs (by classic Raman or SERS on bulk isolates). [18,19,32,33,36] Next, we could show that the generated spectra, in combination with a PLS-DA classification model, allow us to separate between vesicles derived from B16F10 melanoma cells and RBCderived vesicles. The fact that Raman spectroscopy is able to discriminate between vesicles from different cellular origin is in accordance with the very few reports available to date in which it was shown that classic Raman spectroscopy [18] and SERS [32,33] on bulk or clusters of vesicles has discriminative power, even for more similar parent cells.…”
Section: Discussionmentioning
confidence: 93%
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“…Interestingly, most of these pronounced peaks have previously been identified by others when recording Raman spectra of biological samples like erythrocytes [45] or even EVs (by classic Raman or SERS on bulk isolates). [18,19,32,33,36] Next, we could show that the generated spectra, in combination with a PLS-DA classification model, allow us to separate between vesicles derived from B16F10 melanoma cells and RBCderived vesicles. The fact that Raman spectroscopy is able to discriminate between vesicles from different cellular origin is in accordance with the very few reports available to date in which it was shown that classic Raman spectroscopy [18] and SERS [32,33] on bulk or clusters of vesicles has discriminative power, even for more similar parent cells.…”
Section: Discussionmentioning
confidence: 93%
“…[32,33] These few reports show the feasibility of obtaining SERS spectra from an EV sample and the capability to differentiate between EVs from different origin. [32,33] However, it is important to note that these previous analyses were still performed on bulk vesicles from a single cell type. Yet, clinical samples contain EVs from different origin in a mixture, hampering the further implementation of bulk Raman measurements for diagnostic applications.…”
Section: Introductionmentioning
confidence: 99%
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“…Marin et al 30 demonstrated the ability to deposit a spherical cluster of particles on a superhydrophobic surface due to the receding contact line. Ebrahimi et al, 7 Tirinato et al, 8 and De Angelis et al 9 used superhydrophobic surfaces to facilitate dense packing of molecular deposits for improved nanosensor efficiency/sensitivity. We investigate the influence of superhydrophobic surface morphology on evaporative deposition by employing microstructured surfaces with differing pillar pitch as a mean to control the size and localization of particle deposits.…”
Section: Effect Of Superhydrophobic Surface Morphology On Evaporativementioning
confidence: 99%
“…Kerr et al reported SERS analysis on ovarian tumor derived EVs by mixing the EVs with gold nanoparticles 52 , while Tirinato et al showed SERS spectra purportedly arising from EVs on super-hydrophobic nanopillars 53 . However, because the authors did not correct for the SERS signal of the isolation kit used in the study, a substantial portion of that signal is likely to be from that contaminant 48,54 , highlighting some of the difficulty in performing label-free measurements on chemically complex samples such as EVs.…”
Section: B: Surface Enhanced Raman Scattering (Sers)mentioning
confidence: 99%