SERS Encoded Silver Pyramids for Attomolar Detection of Multiplexed Disease Biomarkers

Abstract

Three disease biomarkers can simultaneously be detected at the attomolar level because of a novel surface-enhanced Raman scattering (SERS) encoded silver pyramid sensing system. This newly designed pyramidal sensor with well-controlled geometry exhibits highly sensitive, selective, and reproducible SERS signals, and holds promising potential for biodetection applications.

Dynamic Chiral Nanoparticle Assemblies and Specific Chiroplasmonic Analysis of Cancer Cells

“…The SAXS diameter of the dispersed species associated with these peaks was calculated to be 60.7 ± 2.2 nm. [ 15 ] The hydrodynamic size of the Ag@Au 1 NP assemblies characterized by dynamic light scattering (DLS) was 63.4 ± 3.6 nm, which was similar to those determined by SAXS, illustrating the good uniformity of the assemblies in solution (Figure 3 E). The Ag@Au 1 NP assemblies exhibited an 8 nm red-shifted SPR peak compared to that of monodisperse Ag@Au 1 NPs (Figure 2 F).…”

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

“…Thanks to the developments in the spectroscopic information techniques, nanofabrication routines and novel detection schemes, SERS has been established as a powerful tool in sensing and detecting at molecular level [3,203]. Since the pioneering works of Nie and Emory [204] and Kneipp et al [205] reporting the single molecule detection via SERS, it has been extensively exploited for the detection of different molecules and disease markers at the molecular level [206][207][208][209][210][211][212].…”

Spatially, Temporally, and Quantitatively Controlled Delivery of Broad Range of Molecules into Selected Cells through Plasmonic Nanotubes

“…[ 14 ] The introduction of plasmonic systems in this kind of experiments can be of great interest since it enables the exploitation of Raman spectroscopy that provides a deeper insight into the cellular biochemical environment and its local changing at the molecular level. [15][16][17][18][19] Finally, both chemical and physical methods do not afford precise control over the amount of molecules effectively delivered inside the cell. Moreover, they allow virtually any molecule present in the extracellular fl uid to pass into the cell thus inducing nonspecifi c uptake.…”