SERS of the anti‐inflammatory drug piroxicam adsorbed on the surface of silver or gold colloids as nanocarrier model

This review, published annually, provides an overview of advances in the field of Raman spectroscopy as found in papers published in the preceding calendar year in the Journal of Raman Spectroscopy (JRS), as well as in trends over the past decade across journals that have published papers important to the field of Raman spectroscopy. This information is obtained from statistical data on article counts obtained from Clarivate Analytics' Web of Science Core Collection by year and by subfield of Raman spectroscopy. Additional information is gleaned from presentations at the IX International Conference on Advanced Vibrational Spectroscopy (ICAVS‐9) in Victoria, British Columbia, Canada, in June 2017 and those featuring Raman scattering at SCIX 2017 organized by the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) in Reno, Nevada, USA, in October 2017. Coverage is also provided for topics from the European Conference on Non‐linear Optical Spectroscopy (ECONOS 2017) held in April 2017 in Jena, Germany, and the Ninth Congress on the Application of Raman in Art and Archaeology (RAA 2017) in October 2017 in Evora, Portugal. Finally, papers published in JRS in 2016 are highlighted and arranged by topics at the frontier of Raman spectroscopy. Based on this survey information, it is clear that Raman spectroscopy maintains a rapidly expanding influence across a wide range of novel disciplines and applications that provide sensitive photonic information of matter at the molecular level.

Section: Surface‐enhanced Raman Spectroscopymentioning

confidence: 99%

Section: Theoretical Aspects Of Sers Enhancementmentioning

confidence: 99%

Recent advances in linear and non‐linear Raman spectroscopy. Part XI

Nafie

2017

“…Raman spectroscopy has been applied to molecular imaging and analytics for biomedical imaging . Recently, surface‐enhanced Raman scattering (SERS) has been introduced to study the interfacial interactions between biologically important species and nanostructured materials . Over the past several decades, the chemical synthesis has led to the discovery and development of cancer therapeutic agents based on the understanding of drug uptake, molecular interaction, and cellular process .…”

Section: Introductionmentioning

confidence: 99%

“…[1] Recently, surface-enhanced Raman scattering (SERS) has been introduced to study the interfacial interactions between biologically important species and nanostructured materials. [2][3][4][5][6] Over the past several decades, the chemical synthesis has led to the discovery and development of cancer therapeutic agents based on the understanding of drug uptake, molecular interaction, and cellular process. [7] Much attention has been paid to the application of nanoparticulate intracellular delivery of anticancer drugs to cure cancers.…”

Section: Introductionmentioning

confidence: 99%

Raman spectroscopy and density functional theory study of energetically closely separated C₂′‐endo and C₃′‐endo pentose forms in purine nucleoside analogue drug‐gold conjugates

Ganbold

Nguyen

et al. 2018

We performed a vibrational analysis of a cyclin‐dependent kinase inhibitor as an anticancer drug using Raman spectroscopy and quantum mechanical calculations. BMK‐Y101, a purine nucleoside analogue cyclin‐dependent kinase inhibitor, was found to adsorb on gold nanoparticles as evidenced by ultraviolet–visible absorption spectroscopy. Density functional theory (DFT) calculations were introduced to examine the energetic stabilities of the tautomeric amino and imino purine rings as well as C3′‐endo and C2′‐endo pentose forms for the possible binding geometries to 6‐atom gold clusters. DFT calculations predicted that the N9 binding mode of the C2′‐endo amino purine conformer would be the most stable in coordination with the gold atoms, despite very small energy differences of 0.026 kcal/mol to the second stable conformer of the N1 coordinated state. Surface‐enhanced Raman scattering (SERS) spectra were analyzed with appropriate vibrational assignments according to the DFT calculations and potential energy distribution analysis. The vibrational band at ~1,460 cm−1, which can be ascribed to the ν(N9–C4)(20%) + ν(N3–C4)(13%) + ν(C10–C7)(12%) + ν(C7–C8)(12%) + ν(N3–C2)(11%) mode for the N9‐coordination on Au6, appeared to be the most prominent in the SERS spectra, as predicted from the DFT calculations. BMK‐Y101 appeared to be detached from gold nanoparticles efficiently not in cell culture media but in hepatocarcinoma cells. Our findings indicate that quantum mechanical DFT calculations can be successfully implemented to interpret the SERS spectral features of the nucleoside drug on Au surfaces.

“…This spectroscopic approach is an indispensable tool for the investigation of surface phenomena. In particular, the plasmonic properties of nanostructured surfaces as well as the state of adsorbed molecules can be evaluated by SERS. There are many ways to perform a SERS experiment, for example, in colloidal solutions or on planar substrates.…”

Section: Introductionmentioning

confidence: 99%

SERS investigation of neocuproine adsorption on silver: Influence of electrode potential on methyl groups

Solovyeva

Rakhimbekova

Lanchuk

et al. 2017

Study of molecules adsorption on charged surfaces is important for biologically relevant substances where the potential at the interface such as living cell membrane is a significant parameter in the processes of their transportation or transmembrane penetration. In this work, a hybrid optical/electrochemical surface‐enhanced Raman scattering (SERS) technique was applied to get new insight into the adsorption state and conformational equilibrium of neocuproine, which serves as a nucleic acid biosensor in clinical diagnostics and has biological activity towards several types of carcinoma. The density functional theory calculations performed for several rotational conformations and their anion radicals were used to determine the geometrical and energetic characteristics, to evaluate the rotational barrier, to obtain the vibrational assignment, and to consider the metal‐adsorbate charge transfer. The dependence of SERS spectra on surface potential is ascribed to a change of the rotational dynamics of methyl groups from hindered to almost free at potentials ≤−200 mV. It is demonstrated for the first time that SERS spectroscopy is capable to recognize the surface species, which differ in the methyl group internal rotation.