SERS sensing for cancer biomarker: Approaches and directions

Vázquez-Iglesias, Lorena; Stanfoca Casagrande, Giovanna Maria; García-Lojo, Daniel; Ferro Leal, Letícia; Ngo, Tien Anh; Pérez-Juste, Jorge; Reis, Rui Manuel; Kant, Krishna; Pastoriza-Santos, Isabel

doi:10.1016/j.bioactmat.2023.12.018

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2023.12.018

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SERS sensing for cancer biomarker: Approaches and directions

Lorena Vázquez-Iglesias,

Giovanna Maria Stanfoca Casagrande,

Daniel García-Lojo

et al.

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Cited by 20 publications

References 162 publications

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Stable Hydrogen‐Bonded Cobalt‐porphyrin Framework for High‐Performance Electrochemical Detection of Carcinoembryonic Antigen

Wang,

Han,

Waterhouse

et al. 2024

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The accurate and sensitive detection of low‐abundance cancer‐related biomarkers in blood remains a key technical challenge in clinical applications. Herein, a simple and accurate sandwich‐type electrochemical immunosensor based on a stable hydrogen‐bonded cobalt‐porphyrin framework (Co‐HOF) was successfully developed for the ultrasensitive detection of the cancer‐related biomarker, carcinoembryonic antigen (CEA). The antibody‐modified Co‐HOF forms a sandwich structure with the CEA aptamer electrode exclusively in the presence of CEA, enabling the specific electrochemical detection of CEA. The electrochemical signal increased linearly with the concentration of CEA, demonstrating a wide linear range (0.001–50 ng mL−1) and a low detection limit (0.22 pg mL−1), surpassing the performance of commercial ELISA kits and most reported detection methods. The sensor was successfully employed for CEA detection in spiked human serum, with recoveries ranging from 85.04% to 105.20%. Additionally, we collected blood samples from colorectal cancer patients and healthy individuals to clinically validate the sensor, observing that CEA levels increased with cancer progression. The sensor detection results showed strong consistency (R2 = 0.995) with those obtained from commercial ELISA kits, demonstrating the proposed sensor's practicality for clinical detection of CEA and related cancer biomarkers.

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Stable Hydrogen‐Bonded Cobalt‐porphyrin Framework for High‐Performance Electrochemical Detection of Carcinoembryonic Antigen

Wang,

Han,

Waterhouse

et al. 2024

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show abstract

Plasmonics-enhanced spikey nanorattle-based biosensor for direct SERS detection of mRNA cancer biomarkers

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Atta,

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et al. 2024

Anal Bioanal Chem

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Photonics-powered augmented reality skin electronics for proactive healthcare: multifaceted opportunities

Taha,

Addie,

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SERS sensing for cancer biomarker: Approaches and directions

Cited by 20 publications

References 162 publications

Stable Hydrogen‐Bonded Cobalt‐porphyrin Framework for High‐Performance Electrochemical Detection of Carcinoembryonic Antigen

Stable Hydrogen‐Bonded Cobalt‐porphyrin Framework for High‐Performance Electrochemical Detection of Carcinoembryonic Antigen

Plasmonics-enhanced spikey nanorattle-based biosensor for direct SERS detection of mRNA cancer biomarkers

Photonics-powered augmented reality skin electronics for proactive healthcare: multifaceted opportunities

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