Sertaconazole Nitrate Shows Fungicidal and Fungistatic Activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, Causative Agents of Tinea Pedis

Abstract

The fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 g/ml, respectively, although values were higher for T. mentagrophytes than for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.

Antifungal drug susceptibility testing of dermatophytes: Laboratory findings to clinical implications

“…[52] Other than terbinafine, clotrimazole, and itraconazole, newly introduced antifungal drugs including sertaconazole, luliconazole and lanoconazole, amorolfine, bifonazole, and miconazole have also been evaluated by in- vitro antifungal testing against dermatophytes. [555657] ME1111 is a newer antifungal agent mainly used as a topical agent for the treatment of onychomycosis. Ghannoum and co-workers evaluated and standardized the activity of the ME 1111 antifungal agent by performing CLSI M38- A2 methodology against three isolates ( T. mentagrophytes , T. rubrum , and E. floccosum ) along with ATCC strain of T. rubrum and T. mentagrophytes as quality control.…”

<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

“…This increase has numerous causes such as susceptible population, immunocompromised individuals, fact associated with the practice of sports, wearing shoes with poor ventilation, use of public pools, and manicure instruments [2,3].…”

A comparative randomized open label study to evaluate efficacy, safety and cost effectiveness between topical 2% sertaconazole and topical 1% butenafine in tinea infections of skin

“…[ 3 ] Sertaconazole possesses both fungistatic and fungicidal activity depending upon its concentration. [ 4 5 ] It has anti- inflammatory activity also. Adverse events reported with sertaconazole are contact dermatitis, dry skin, application site reactions.…”