Sertoliform Cystadenoma of the Rete Testis: Report of a Case and Review of the Literature

Lahouti, Arash H.; Brodherson, Michael; Larish, Yaniv; Unger, Pamela

doi:10.1177/1066896917704304

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The most recent case of Sertoliform cystadenoma was presented by Lahouti et al in a 39-year-old male with a right superior pole testicular mass, 5 in which serum tumor markers were negative. The final pathology report revealed sertoliform cystadenoma with immunohistochemical examination intense positive for Inhibin, cytokeratin CAM5.2, PAX8.…”

Section: Discussionmentioning

confidence: 99%

“…The most important morphologic criteria required for diagnosis are the involvement of testicular mediastinum with the preservation of the parietal tunica vaginalis, in the absence of other lesions. 5,10 Although current recommendations are in favor of considering every scrotal mass as malignant until proven otherwise, we propose in selected cases where clinical history is in favor of benign lesion and patients desire maximum fertility preservation the alternative of organ sparing surgery. Testispreserving surgery should always be accompanied by frozen section examination, due to the fact that it has a high concordance with the final pathology result.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…4 All previously reported cases of sertoliform cystadenoma have been managed by radical surgery-inguinal orchiectomy. 5,6 We present the first case of a Sertoliform cystadenoma in a 42-year-old male managed by conservative surgery.…”

Section: Introductionmentioning

confidence: 99%

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First report of testis‐sparing surgery for sertoliform cystadenoma: case presentation and review of literature

Rahota¹,

Ploussard²,

Gautier³

et al. 2021

IJU Case Reports

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Introduction: Sertoliform cystadenoma is a very rare, benign lesion of the rete-testis difficult to distinguish from other malignancies of the testicle. Case presentation: We present the case of a 42-year-old male who presented with a right testicular mass, asymptomatic for 1 year. Clinical examination revealed a palpable, painless, and well-delimited right testicular superior pole nodule. Testicular ultrasound confirmed the nodule, whereas serum tumoral markers were normal. The patient underwent inguinal partial orchiectomy. Intraoperative excisional biopsy and frozen section pathology were performed, reporting undetermined tumoral origin with negative surgical margins. Ischemia time was 12 minutes. The final pathology report showed a Sertoliform cystadenoma of rete testis, with immunomorphology positive for AE1, CK7, and negative surgical margins. Conclusion: To our knowledge, this is the first report of testicular sparing surgery for Sertoliform cystadenoma, a very rare benign tumor of rete testis. All previously reported cases were managed by radical inguinal orchidectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

First report of testis‐sparing surgery for sertoliform cystadenoma: case presentation and review of literature

Rahota¹,

Ploussard²,

Gautier³

et al. 2021

IJU Case Reports

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Testis and Paratesticular Tissues

Wilkerson

Liu

2022

Handbook of Practical Immunohistochemistry

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The Morphologic Spectrum of Sertoliform Cystadenoma of the Rete Testis

Paluru¹,

Ulbright

Amin

et al. 2018

American Journal of Surgical Pathology

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Sertoliform cystadenoma of the rete testis (SCRT) is rare with only 9 cases reported to date in the literature, none with follow-up. Four large genitourinary pathology consult services were searched. We identified 15 cases of SCRT. Men were 21 to 84 years old (mean, 46 y) and had testicular discomfort or mass. Other findings were seminoma (n=1), spermatocele (n=2), hydrocele (n=1), varicocele (n=1), and scrotal hematoma (n=1). Eight had preoperative serum tumor markers, which were normal. Tumors ranged from 0.3 to 4 cm (mean, 1.5 cm). All of them were well circumscribed with solid and cystic features and occupied on average, 73% of the rete (20% to 100%). The tumors were mostly confined within dilated channels of the rete testis and showed classic features consisting of: (1) tubules with well-formed lumina in 87% of cases; (2) well-formed tubules with no lumina in 87% of cases; and (3) cords/nests in hyalinized or myxoid stroma in 73% of cases. Other patterns included: (1) solid/sheet growth in 26% of cases; (2) individual cells in 13% of cases; (3) festoons in 13% of cases; (4) branching tubules in 7% of cases; and (5) papillary in 7% of cases. Cells were cuboidal with round to oval nuclei with small nucleoli, except at the periphery where projections into rete tubules had a more columnar appearance. In the festooning pattern, nuclei were pseudostratified and columnar with prominent nucleoli and nuclear grooves. In 4 cases, tumor extended into adjacent seminiferous tubules surrounded by dense peritubular fibrosis, with in some cases small cysts lined by flattened epithelium containing pale lightly granular material. All cases lacked necrosis and significant atypia. Mitoses ranged from 0 to 2 per 10 high-power field. Follow-up ranged from 4 to 170 months with mean of 97 months. For the 13 cases with information, all patients were alive, except for 3 who died of either unrelated causes (9.2 and 10 y) or of unknown cause (4.8 y at age 89 y). We performed immunohistochemistry for steroidogenic factor 1 and inhibin in 4 of our cases, where 3 (75%) were positive for both markers. We also describe 2 additional cases which morphologically resembled SCRT but had more atypical features. This study highlights that SCRT has variable morphology. We also verify the benign nature of the lesion and its lack of association with any syndromes.

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Sertoliform Cystadenoma of the Rete Testis: Report of a Case and Review of the Literature

Cited by 4 publications

References 8 publications

First report of testis‐sparing surgery for sertoliform cystadenoma: case presentation and review of literature

First report of testis‐sparing surgery for sertoliform cystadenoma: case presentation and review of literature

Testis and Paratesticular Tissues

The Morphologic Spectrum of Sertoliform Cystadenoma of the Rete Testis

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