Sertraline and its iodine product: Experimental and theoretical vibrational studies

Escudero, Graciela; Curotto, Verónica Ferraresi; Laino, Carlos Horacio; Diez, Reinaldo Pis; Williams, Patricia Ana María; Ferrer, Evelina G.

doi:10.1016/j.saa.2012.11.076

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…Previous work showed that sertraline hydrochloride in presence of iodine led immediately to the appearance of a new CT band located at 257 nm. This band has a K c value of 3277.48 L mol − 1 that indicates strong activity (much larger than the 100 L mol − 1 reference value) [17]. In this work, sequential addition of increasing concentrations of (SerH 2 ) 2 [CuCl 4 ] complex on iodine solution produced a reduction of the iodine band intensity but no CT band was observed.…”

Section: Antimicrobial Activitymentioning

confidence: 52%

“…Iodine complexation was assayed following our reported methods, based on Lang's method [17]. Experiments concerning lactoperoxidase from bovine milk (LPO)-inhibition were performed as follows using phosphate buffer (pH 7) at 25°C.…”

Section: In Vitro Biological and Pharmacological Activities 231 Anmentioning

confidence: 99%

“…Based in those possibilities, the ability of the complex to form charge transfer-iodine complex and to inhibit LPO has been evaluated. Due to the fact that sertraline hydrochloride-iodine interaction was previously shown to lead to charge-transfer complex with iodine [17], its effect on LPO was only assessed in this work.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…The formation of stable charge-transfer complexes with the compound of our interest and the iodine molecule were studied at the beginning of our research. In this context, a series of methimazole-derived complexes were considered, as well as the demonstration that sertraline efficiently acted as an iodine captor [17,18]. According to these considerations, the determination of the antithyroid activity of the sertraline-derived complex and lactoperoxidase inhibition experiments were measured.…”

Section: Introductionmentioning

confidence: 99%

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Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]

Martini

Parente

Toledo³

et al. 2017

Journal of Inorganic Biochemistry

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In the current study the ability of copper complex to exert multiple biological activities is combined with the pharmacological action of sertraline (SerHCl, antidepressant drug). The hydrated and anhydrous forms of the tetrachlorocuprate(II) salts, namely (SerH)[CuCl]·½HO and (SerH)[CuCl], were synthesized and characterized by physicochemical methods. The crystal structures were determined by X-ray diffraction methods. The hydrate complex crystallizes in the monoclinic P2 space group with a=8.0807(2) Å, b=36.2781(8) Å, c=12.6576(3) Å, β=95.665(2)°, and Z=4 molecules per unit cell and the un-hydrate in P2 with a=13.8727(6) Å, b=7.5090(3) Å, c=18.618(1) Å, β=104.563(6)°, and Z=2. It has been suggested that Cu(II) ions might be critical in the development of mood disorders, showed potent biocidal activity, and also acted as analgesic adjuvant. To improve sertraline efficiency, the antidepressant and analgesic activities of the complex have been assessed in rats denoting a marked synergistic effect. Antithyroid and antimicrobial activities were also evaluated. Because depressive disorders and hyperthyroidism diseases led to an oxidative stress state, antioxidant capability has also been tested. The complex behaved as a good superoxide radical scavenger (IC=6.3×10M). The ability of the complex to act as bromoperoxidase mimic was assessed. A pseudo-first order constant of k=0.157±0.007min has been determined. The complex evidences promising biological-pharmacological activities and the albumin binding studies showed a K of 2.90×10M showing an improvement in the uptake of sertraline by albumin at 8h incubation (time required for effective interaction of sertraline with the protein).

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Section: Antimicrobial Activitymentioning

confidence: 52%

Section: In Vitro Biological and Pharmacological Activities 231 Anmentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]

Martini

Parente

Toledo³

et al. 2017

Journal of Inorganic Biochemistry

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“…Iodine complexation was assayed based on Lang's method [23] Iodine was bi-sublimated and kept in dark in a desiccator containing P 2 O 5 . Spectroscopic grade solvent were used.…”

Section: Anti-thyroid Activitymentioning

confidence: 99%

Antidepressant and antinociceptive activities in animal models and in vitro assessment of the anti-thyroid activity of bis(DL-pyroglutamate)magnesium complex

Martini

Parente

Toledo

et al. 2019

Pharmacological Reports

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Background: Magnesium is an essential element related with biochemistry of the brain and different types of depression have been associated with its deficiency. Methods: The structure of a novel magnesium bis(DL-pyroglutamate) (Mg(DL-pGlu) 2 ) was elucidated by X-ray crystallography. Wistar rats were used in the in vivo experiments. The antidepressant-like effect was assessed by the forced swim test (FST) and the antinociceptive activity was evaluated using hot plate test. In both, non-specific effects were evaluated by the open field test. Anti-thyroid activity was examined using Lang's method. Albumin binding behavior was evaluated by 3D fluorescence spectroscopy.Results: For the Mg(DL-pGlu) 2 complex (30 mg/kg), the FST test on Wistar rats revealed a decrease of 22% in the immobility time and an increment of 106% in the swimming time. The compound alters neither the locomotor activity nor the body weight after chronic administration. At the same dose, it showed antinociceptive activity, increasing the response latency. It blocks iodination reactions generating a charge transfer complex with iodine hence indicating anti-thyroid activity (K c = 45366.5 AE 29 M À1 ). Albumin 3D fluorescence spectroscopy experiments showed intensity increase of peak A and decrease of peak B. Conclusions: The results showed that the new compound produced a lowering of the immobility time and an increment of the swimming ability of the rats. The compound is able to increase the response latency in 70.0%, to capture iodine (anti-thyroid activity) and to interact with albumin through covalent type of interaction of the free NH groups.

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DFT study of sertraline hydrochloride antidepressant drug

et al. 2023

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Sertraline and its iodine product: Experimental and theoretical vibrational studies

Cited by 9 publications

References 29 publications

Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]

Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]

Antidepressant and antinociceptive activities in animal models and in vitro assessment of the anti-thyroid activity of bis(DL-pyroglutamate)magnesium complex

DFT study of sertraline hydrochloride antidepressant drug

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