Sertraline as a treatment for PTSD: a systematic review and meta-analysis

Mooney, Paul; Oakley, Janette; Ferriter, Michael; Travers, Raymond

doi:10.1017/s0790966700008478

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…There were 12 additional pharmacotherapy studies identified from the ACPMH guidelines, of which seven were already present in the above reviews and were removed as duplicates. A further four did not meet our inclusion criteria, [71][72][73][74] leaving one additional study which was included. 75…”

Section: Resultsmentioning

confidence: 99%

Pharmacotherapy for post-traumatic stress disorder: Systematic review and meta-analysis

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Pharmacotherapy for post-traumatic stress disorder: Systematic review and meta-analysis

et al. 2015

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“…A number of meta-analyses of medication treatment for PTSD have been conducted to date, synthesizing data from trials of individual agents (Adamou et al 2007 ;Mooney et al 2004), as well as comparing treatment efficacy across agents (Penava et al 1996 ;Stein et al 2006 ;Stewart & Wrobel, 2009 ;Van Etten & Taylor, 1998). Although the findings of these metaanalyses have in general supported the use of phar-macotherapy, and SSRIs in particular, in treating PTSD, their conclusions have been weakened by methodological shortcomings (listed in Table 2).…”

Section: Meta-analysis Of Pharmacotherapy For Ptsdmentioning

confidence: 99%

Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD)

Ipser

Stein

2011

Int. J. Neuropsychopharm.

174

129

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Post-traumatic stress disorder (PTSD) is a prevalent and disabling disorder. Recognition of neurobiological abnormalities associated with this condition suggests the potential efficacy of medication in its treatment. Nevertheless, questions regarding the efficacy of medications remain, despite general endorsement by clinical practice guidelines of selective serotonin reuptake inhibitors (SSRIs) as first-line agents in treating PTSD. This paper reviews evidence from randomized controlled trials (RCTs) for the efficacy of acute and long-term pharmacotherapy for PTSD, including the treatment of refractory PTSD. In addition, we conducted a systematic meta-analysis to compare the efficacy of different medications in treating PTSD. The effects of methodological study features (including year of publication, duration, number of centres) and sample characteristics (proportion of combat veterans, gender composition) were also tested. The largest body of evidence for short- and long-term efficacy of medication currently exists for SSRIs, with promising initial findings for the selective noradrenergic reuptake inhibitor venlafaxine and the atypical antipsychotic risperidone. Treatment effect was predicted by number of centres and recency of the study, with little evidence that sample characteristics predicted response. Evidence for the effectiveness of benzodiazepines is lacking, despite their continued use in clinical practice. Finally, the α1 antagonist prazosin and the atypical antipsychotics show some efficacy in treatment-resistant PTSD. Adequately powered trials that are designed in accordance with best-practice guidelines are required to provide conclusive evidence of clinically relevant differences in efficacy between agents in treating PTSD, and to help estimate clinical and methodological predictors of treatment response.

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“…La evidencia actual apoya el uso inicial de inhibidores selectivos de la recaptura de serotonina 26,35,38 (ISRS), de los cuales la sertralina es el único que cuenta con metaanálisis que avalan su efectividad 53,54 . Los tratamientos deberían mantenerse por un período largo, en nuestra experiencia, hasta completar al menos un año de remisión de síntomas 35 .…”

Section: Nivel IV Manejo Psiquiátrico Generalunclassified