Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress

Mikail, Hudu Garba; Dalla, Christina; Kokras, Nikolaos; Kafetzopoulos, Vasilios; Papadopoulou-Daifoti, Z.

doi:10.1016/j.physbeh.2012.06.016

Cited by 39 publications

(31 citation statements)

References 37 publications

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“…Interestingly, the current study shows that neonatal TS was able to decrease depression‐like behavior, as observed by the increased swimming time and the decreased immobility time in FST. This animal model has been widely used to assess potential activity of antidepressant drugs (Cryan et al, 2005; Shaw et al, 2007; Mikail et al, 2012). In this sense, decreased swimming time together with increased immobility time in FST are indicators of depressive behavior, which may be reversed by antidepressant drugs (Cryan et al, 2005; Porsolt et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

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Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Freitas¹,

Antoniazzi

Segat³

et al. 2015

Intl J of Devlp Neuroscience

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It is well known that events which occur in early life exert a significant influence on brain development, what can be reflected throughout adulthood. This study was carried out in order to assess the influence of neonatal tactile stimulation (TS) on behavioral and morphological responses related to depression-like and anxiety-like behaviors, assessed following the administration of sertraline (SERT), a selective serotonin re-uptake inhibitor (SSRI). Male pups were submitted to daily TS, from postnatal day 8 (PND8) to postnatal day 14 (PND14), for 10 min every day. On PND50, adult animals were submitted to forced swimming training (15 min). On PND51, half of each experimental group (UH and TS) received a single sub-therapeutic dose of sertraline (SER, 0.3mg/kg body weight, i.p.) or its vehicle (C, control group). Thirty minutes after injection, depression-like behaviors were quantified in forced swimming test (FST, for 5 min). On the following day, anxiety-like behaviors were assessed in elevated plus maze (EPM), followed by biochemical assessments. TS per se increased swimming time, decreasing immobility time in FST. Besides, TS per se was able to increase frequency of head dipping and time spent in the open arms of EPM, resulting in decreased anxiety index. In addition, groups exposed to TS showed decreased plasma levels of corticosterone per se. Interestingly, while TS exposure significantly potentiated the antidepressant activity of a subtherapeutic dose of SERT, this drug was able to exacerbate TS-induced anxiolytic activity, as observed in FST and EPM, respectively. Decreased plasma levels of both corticosterone and cortisol in animals exposed to TS and treated with SERT are able to confirm the interesting interaction between this neonatal handling and the antidepressant drug. From our results, we conclude that neonatal TS is able to exert beneficial influence on the ability to cope with stressful situations in adulthood, preventing depression and favorably modulating the action of antidepressant drugs.

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Section: Discussionmentioning

confidence: 99%

“…SERT was the antidepressant drug chosen because it has been frequently reported in studies involving animal models (Ulloa et al, 2010; Mikail et al, 2012; Kaygisiz et al, 2014). Thirty minutes following the injections, animals were submitted to forced swimming test (FST).…”

Section: Methodsmentioning

confidence: 99%

Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Freitas¹,

Antoniazzi

Segat³

et al. 2015

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

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“…Similarly, the ratios of DOPAC/DA and HVA/DA were calculated as an index of DA turnover rates. Turnover rates estimate the serotonergic and dopaminergic activities better than individual neurotransmitter and metabolite tissue levels as they reflect 5-HT and DA release and/or metabolic activity as described elsewhere (Dalla et al, 2008; Kokras et al, 2009; Mikail et al, 2012). …”

Section: Methodsmentioning

confidence: 99%

Neudesin is involved in anxiety behavior: structural and neurochemical correlates

Novais

Ferreira

Marques

et al. 2013

Front. Behav. Neurosci.

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Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/dark box (LDB) and novelty suppressed feeding (NSF) tests, but not in the acoustic startle (AS) test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.

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“…Both sexes were tested in the present study because major depression is more prevalent in human females than males (Piccinelli and Wilkinson 2000; Parker and Brotchie 2010; Hirschfeld 2012). In addition, we measured neuronal monoamine activity after adolescent SSRI exposure, since changes in serotonin utilization are associated with the beneficial effects of repeated SSRI treatment (Mikail et al 2012; Nagano et al 2012; Shishkina et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Effects of acute or repeated paroxetine and fluoxetine treatment on affective behavior in male and female adolescent rats

et al. 2015

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Rationale The SSRI antidepressant fluoxetine is one of the few drugs that is effective at treating depression in adolescent humans. In contrast, the SSRI paroxetine has limited efficacy and is more at risk for inducing suicidal behavior. Objective The purpose of the present study was to more fully characterize the differential actions of paroxetine and fluoxetine. Methods In Experiment 1, male and female rats were injected with paroxetine (2.5 or 10 mg/kg), fluoxetine (10 mg/kg), or vehicle for 10 days starting on postnatal day (PD) 35, and affective behaviors were assessed using sucrose preference and elevated plus maze tasks. A separate set of rats were used to examine monoamine levels. In Experiment 2, rats were injected with paroxetine (2.5, 5 or 10 mg/kg), fluoxetine (5, 10 or 20 mg/kg), or vehicle during the same time frame as Experiment 1 and anxiety-like behaviors were measured using elevated plus maze, light/dark box, and acoustic startle. Results Repeated SSRI treatment failed to alter sucrose preference, although both paroxetine and fluoxetine reduced time spent in the open arms of the elevated plus maze and light compartment of the light/dark box. Paroxetine, but not fluoxetine, enhanced acoustic startle and interfered with habituation. Serotonin turnover was decreased by both acute and repeated fluoxetine treatment but unaltered by paroxetine administration. Discussion These results show that repeated treatment with paroxetine and fluoxetine has dissociable actions in adolescent rats. In particular, paroxetine, but not fluoxetine, increases acoustic startle at low doses and may increase sensitivity to environmental stressors.

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Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress

Cited by 39 publications

References 37 publications

Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Neudesin is involved in anxiety behavior: structural and neurochemical correlates

Effects of acute or repeated paroxetine and fluoxetine treatment on affective behavior in male and female adolescent rats

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