Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period

O’Brien, Kimberly; Donangelo, Carmen M.; Ritchie, Lorrene D.; Gildengorin, Ginny; Abrams, Steven A.; King, Janet C.

doi:10.3945/ajcn.111.029231

Cited by 20 publications

(11 citation statements)

References 45 publications

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“…Detailed data on vitamin D metabolism, including 25(OH)D, parathyroid hormone, 1,25-dihydroxyvitamin D, serum total calcitriol, vitamin D receptor, placental cytochrome P (CYP) 27B1 and CYP24A1, interleukin-6 (IL-6), leptin, and osteoprotegerin, have been previously published. 8,15,[44][45][46][47][48] …”

Section: Biochemical Assessment Of Vitamin D Statusmentioning

confidence: 99%

Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents

et al. 2015

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Vitamin D is linked to a number of adverse pregnancy outcomes through largely unknown mechanisms. This study was conducted to examine the role of vitamin D status in metabolomic profiles in a group of 30 pregnant, African American adolescents (17.1 + 1.1 years) at midgestation (26.8 + 2.8 weeks), in 15 adolescents with 25-hydroxy vitamin D (25(OH)D) !20 ng/mL, and in 15 teens with 25(OH)D <20 ng/mL. Serum metabolomic profiles were examined using gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry. A novel hierarchical mixture model was used to evaluate differences in metabolite profiles between low and high groups. A total of 326 compounds were identified and included in subsequent statistical analyses. Eleven metabolites had significantly different means between the 2 vitamin D groups, after correcting for multiple hypothesis testing: pyridoxate, bilirubin, xylose, and cholate were higher, and leukotrienes, 1,2-propanediol, azelate, undecanedioate, sebacate, inflammation associated complement component 3 peptide (HWESASXX), and piperine were lower in serum from adolescents with 25(OH)D !20 ng/mL. Lower maternal vitamin D status at midgestation impacted serum metabolic profiles in pregnant adolescents.

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Section: Biochemical Assessment Of Vitamin D Statusmentioning

confidence: 99%

Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents

et al. 2015

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“…23 Based on our results; the mean dietary vitamin D of all study participants was significantly lower than the RDA but was similar to those reported in previous studies. 24,25 Serum 25(OH)D concentration associated with the RDA for vitamin D is 50 nmol/L. 23 All participants at baseline and 1-year postpartum had sufficient serum concentrations of 25(OH)D, greater than 50 nmol/L.…”

Section: Discussionmentioning

confidence: 99%

The Effect of an Exercise Intervention During Early Lactation on Bone Mineral Density During the First Year Postpartum

Colleran¹,

Hiatt²,

Wideman³

et al. 2019

Journal of Physical Activity and Health

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Background: During lactation, women may lose up to 10% of bone mineral density (BMD) at trabecular-rich sites. Previous studies show that resistance exercise may slow BMD; however, the long-term effects of exercise on BMD during lactation have not been reported. Objective: To evaluate the effect of two 16-week exercise interventions (4-to 20-wk postpartum) in lactating women at 1-year postpartum on lumbar spine, total body, and hip BMD. Methods: To increase sample size at 1-year postpartum, two 16-week exercise interventions were combined for analysis. At 4-week postpartum, 55 women were randomized to intervention group (weight bearing aerobic exercise and resistance exercise) or control group (no exercise) for 16-week, with a 1-year postpartum follow-up. BMD was measured by dual-energy X-ray absorptiometry. Repeated-measures analysis of covariance was used to test for time and group differences for BMD controlling for prolactin concentration and dietary calcium at 1-year postpartum. Results: Change in lumbar spine BMD was significantly different over time and between groups from 4week to 1-year postpartum, when controlling for prolactin concentration and dietary calcium. There were no significant differences between groups in total body and hip BMD. Conclusion: These results suggest that resistance exercise may slow bone loss during lactation, resulting in higher BMD levels at 1-year postpartum.

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“…The other reason might be mothers’ perception of the beneficial effect of calcium supplementation on maternal bone loss during lactating. Some studies found little benefits of calcium supplementation on maternal bone loss during lactating [36,39,40], whereas other studies carried out in the U.S. and Brazil suggested that higher calcium intake during early lactation could minimize the bone loss for the mothers who had daily calcium intake less than 500 mg [20,21]. Further investigation on the factors contributing to difference of calcium supplementation between breastfeeding mothers and non-breastfeeding mothers as well as the effect of calcium supplementation on reducing maternal bone loss during lactation or enhancing maternal skeleton remodeling and remineralization after weaning of breastfeeding is recommended.…”

Section: Discussionmentioning

confidence: 99%

“…However, low dietary calcium intake in lactating women has been reported in different regions of China, as shown in Table 1. This suggests that calcium supplementation for lactating women is an important public health issue to mothers in China based on the current evidence about the benefits of calcium intake during lactation on reducing maternal bone loss [20,21,22,23]. …”

Section: Introductionmentioning

confidence: 99%

Increased Calcium Supplementation Postpartum Is Associated with Breastfeeding among Chinese Mothers: Finding from Two Prospective Cohort Studies

Zhao

Binns

et al. 2016

Nutrients

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The calcium supplementation status during the postpartum period among Chinese lactating women is still unclear. The objective of this study is to utilize data from two population-based prospective cohort studies to examine the calcium supplementation status and to identify whether breastfeeding is associated with increased calcium supplementation among Chinese mothers after child birth. Information from 1540 mothers on breastfeeding and calcium supplementation measured at discharge, 1, 3, and 6 months postpartum were extracted to evaluate the association between breastfeeding and calcium supplementation postpartum. A generalized linear mixed model was applied to each study initially to account for the inherent correlation among repeated measurements, adjusting for socio-demographic, obstetric factors and calcium supplementation during pregnancy. In addition, breastfeeding status measured at different follow-up time points was treated as a time dependent variable in the longitudinal analysis. Furthermore, the effect sizes of the two cohort studies were pooled using fixed effect model. Based on the two cohort studies, the pooled likelihood of taking calcium supplementation postpartum among breastfeeding mothers was 4.02 times (95% confidence interval (2.30, 7.03)) higher than that of their non-breastfeeding counterparts. Dietary supplementation intervention programs targeting different subgroups should be promoted in Chinese women, given currently a wide shortage of dietary calcium intake and calcium supplementation postpartum.

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Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period

Cited by 20 publications

References 45 publications

Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents

Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents

The Effect of an Exercise Intervention During Early Lactation on Bone Mineral Density During the First Year Postpartum

Increased Calcium Supplementation Postpartum Is Associated with Breastfeeding among Chinese Mothers: Finding from Two Prospective Cohort Studies

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