Serum 11-deoxycorticosterone levels in adrenal-regeneration hypertension under conditions of quiescence and stress

Bergon, Lloyd; Gallant, Samuel; Brownie, Alexander C.

doi:10.1016/0039-128x(75)90090-2

Cited by 25 publications

(11 citation statements)

References 43 publications

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“…Since no data were available for nonhuman primates, we included in each experiment a plasma sample obtained from a naïve rat that served as a control for the assay. The average rat basal value was comparable to previous published data (Bergon et al 1975).…”

Section: Discussionsupporting

confidence: 81%

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Hypothalamic–pituitary–adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys

et al. 2005

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Section: Discussionsupporting

confidence: 81%

“…Each assay included a rat plasma sample as an internal control. The rat values were 1.43± 0.05 (n=18), which are comparable to previously published data (Bergon et al 1975). The antiserum for DOC was purchased from MP Biomedicals (Orangeburg, NY, USA) and diluted according to manufacturer's instructions.…”

Section: Pharmacological Profilingsupporting

confidence: 85%

Hypothalamic–pituitary–adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys

et al. 2005

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“…Later, and Bergon et al(1975) have confirmed this above controls in peripheral plasma levels of DOC 3 weeks after enucleation in ARH rats. They have supported the hypothesis, initially proposed by Brownie and Skelton (1965), that DOC is the steroid responsible for adrenal regeneration hypertension.…”

Section: Endocrinolsupporting

confidence: 64%

Effect of a Spironolactone Derivative (SC 14266) on Plasma Renin Activity in Adrenal Regeneration Hypertension

et al. 1976

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SynopsisThe effects of treatment with a spironolactone derivative (SC 14266) for 9 experimental weeks on blood pressure and plasma renin activity (PRA) were investigated in unilaterally nephroadrenalectomized rats drinking 1% saline ("unilateral nephrectomy"), unilaterally nephroadrenalectomized and contralaterally adrenal-enucleated rats drinking 1% saline ("adrenal enucleation") and intact rats drinking tap water ("normal").The development of hypertension in"adrenal enucleation"rats was prevented by treatment with SC 14266 and the drug did not significantly affect the blood pressure in either"unilateral nephrectomy"or"normal"rats. SC 14266 did not influence a low level of basal PRA and the blunted response of PRA to furosemide administration in either"unilateral nephrectomy"or"adrenal enucleation"rats. On the other hand, PRA after furosemide administration in "normal" rats receiving SC 14266 was significantly higher than that in those rats treated with vehicle.The results suggest that the mineralocorticoid(s) secreted by the enucleated adrenal has a hypertensogenic property but no effect on the suppression of renin secretion under a high sodium intake and the unilateral nephrectomy.

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“…15 DOC in the fractions collected was measured by radioimmunoassay. 16 Levels of corticosterone were determined by direct radioimmunoassay. 17 …”

Section: Collection Of Serum and Steroid Analysismentioning

confidence: 99%

Resistance to mineralocorticoid-induced hypertensive vascular disease.

Sciotti¹,

Gallant²

1987

Hypertension

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SUMMARY To support our contention that the Wistar-Furth rat is resistant to mineralocorticoid hypertension, we assessed the effects of deoxycorticosterone (DOC) administration or renal artery stenosis on the development of hypertension in the Sprague-Dawley and Wistar-Furth rat strains. Weekly administration of mineralocorticoid in the form of DOC pivalate resulted in rapid, severe hypertensive cardiovascular disease in Sprague-Dawley rats. Within 5 weeks the mean conscious systolic blood pressures in steroid-treated and control rats were 186 ± 4 and 118 ± 5 mm Hg, respectively. In contrast, blood pressures of Wistar-Furth rats were only moderately elevated, even after 10 weeks of DOC pivalate administration (136 ± 2 vs 116 ± 2 mm Hg for controls). Furthermore, none of the steroid-treated Wistar-Furth animals exhibited cardiovascular lesions. In parallel studies, littermates of these rat strains were subjected to renal artery stenosis and blood pressures were determined weekly in conscious rats. Silver clip constriction of the left renal artery, in the presence of the contralateral kidney, resulted in a rapid, sustained elevation of blood pressure in both SpragueDawley and Wistar-Furth rat strains (177 ± 4 and 176 ± 5 mm Hg, respectively). Corticosteroid levels were also determined in DOC-treated Sprague-Dawley and Wistar-Furth rats. The regimen employed resulted in a 10-fold increase in DOC levels as compared with controls, and the levels achieved were comparable in both strains. Thus, the Wistar-Furth rat appears to be selectively resistant to mineralocorticoid hypertensive vascular disease and thus affords a model for studying mechanisms of steroid hypertension. (Hypertension 10: 176-180, 1987) KEY WORDS • hypertension • deoxycorticosterone • resistance • Wistar-Furth rats W E have previously reported that adrenal regeneration hypertension fails to develop in the Wistar-Furth rat strain. 1 WistarFurth rats (W/Fu) do exhibit cardiac and renal hypertrophy, but systolic blood pressure (BP) is minimally elevated and there is a virtual absence of cardiovascular lesions. This model of experimental hypertension was described by Skelton 2 in 1955 and is generally thought to be mediated by mineralocorticoid excess. 3 The identity of the hormone (or hormones) involved has not been clearly defined, although several steroids, including 11-deoxycorticosterone (DOC) and 19-nordeoxycorticosterone have been implicated. 4 ation as compared with those of controls. Again, BP was mildly elevated but cardiovascular lesions were absent. This study and our previous one 1 suggested the possibility that the W/Fu are resistant to mineralocorticoid hypertension. In contrast to our observations, Hall et al. 9 reported that W/Fu exhibit adrenal regeneration hypertension that is indistinguishable from that seen in SpragueDawley rats (SD). However, in a follow-up study, the same authors found that adrenal regeneration hypertension developed in SD at a much faster rate and with greater intensity than in the W/Fu. 10 In fact, BPs of the ...

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Serum 11-deoxycorticosterone levels in adrenal-regeneration hypertension under conditions of quiescence and stress

Cited by 25 publications

References 43 publications

Hypothalamic–pituitary–adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys

Hypothalamic–pituitary–adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys

Effect of a Spironolactone Derivative (SC 14266) on Plasma Renin Activity in Adrenal Regeneration Hypertension

Resistance to mineralocorticoid-induced hypertensive vascular disease.

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