Serum 17β-estradiol fails as a marker in identification of aggressive tumour disease in patients with localized prostate cancer

Schnoeller, Thomas; Steinestel, Julie; Zengerling, Friedemann; Schrader, Andres Jan; Jentzmik, Florian

doi:10.1007/s00345-015-1567-7

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…At least the latter one was suggested to be higher in diabetes in a previous report (Kronig et al 2017). However, as obesity is a risk factor for lymph node metastasis in PCa (Schnoeller et al 2015), higher body weight in diabetes could have confounded earlier analyses. We now excluded this possibility and ascertained more frequent lymph node infiltration in diabetes independent of body weight.…”

Section: Endocrine-related Cancermentioning

confidence: 82%

Higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes

Lutz¹,

Todenhöfer²,

Wagner³

et al. 2018

Endocrine-Related Cancer

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Section: Endocrine-related Cancermentioning

confidence: 82%

Higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes

Lutz¹,

Todenhöfer²,

Wagner³

et al. 2018

Endocrine-Related Cancer

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“…In another study, it was reported that low TTE correlated with high FSH and that both were associated with high-grade tumors (24). A study assessing EST level reported no significant correlation between EST and locally advanced PCa (25). However, our previous EST analysis in a locally advanced PCa (T3a and T3b) group revealed significant correlation between EST and T3b disease (9).…”

Section: Discussionmentioning

confidence: 81%

Predictive Value of Hormonal Evaluation Before Prostate Needle Biopsy on Prostate Cancer T Stage and Prognosis

Çelik¹,

Yörükoğlu²,

Bozkurt³

et al. 2018

uob

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In this study we evaluated the hormone data before prostate needle biopsy (PNB) in patients who underwent retropubic radical prostatectomy (RRP) due to prostate adenocarcinoma (PCa). Correlations between the patients' RRP pathology results, recurrence-free survival (RFS), and hormone data were investigated. Materials and Methods: Patients were evaluated in two groups according to RRP pathologic T stage: T2 (group 1) and T3 (group 2). Then patients were assessed in two groups based on total testosterone (TTE) values: >300 ng/dL and <300 ng/dL. The preoperative data, hormone data, RRP pathologic data, and biochemical recurrence and RFS results were compared between these groups. Results: A total of 81 patients were evaluated. The mean follow-up time was 37.7 months. Mean recurrence free survival (RFS) among all patients was 94.2±7 months. In multivariate analysis of the preoperative data, TTE/prostate volume (p=0.015) and PNB tumor percentage (p=0.004) were significantly higher in group 2 (n=32) compared to group 1 (n=49). In the postoperative data, RRP pathology Gleason score (GS) (p=0.015) and tumor volume (p=0.02) were significantly higher in group 2. RFS was 99.2±5.8 months in group 1 and 77±12.1 months in group 2 (p=0.02). When patients were assessed according to TTE levels, of the pre-and postoperative data only RRP pathology T stage, GS, and lymph node positivity were significantly higher in the TTE <300 ng/dL group (n=30) compared to the TTE >300 ng/dL group (n=51). The biochemical recurrence rates and RFS times (87.7±13.8 months and 91.3±6.4 months, respectively) were similar between the groups (p=0.571). Conclusion: We demonstrated a correlation between locally invasive PCa and low TTE measured before PNB and low TTE density. In particular, TTE values <300 ng/dL were associated with high pathologic T stage, GS, and lymph node positivity.

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“…Conversely, within PCa cell lines characterized by a lower ER-α/ER-β ratio, E2 encourages the upregulation of uncoupling proteins (UCPs) and other antioxidant enzymes [110]. As far as we know, no correlation has been established between obesity and high levels of serum E2 with the development, progression, or aggressiveness of PCa [111]. Nonetheless, a more cohesive correlation has been established between the increased expression of adipokines, in particular leptin, in individuals with obesity and the development and progression of PCa (Figure 3).…”

Section: Can Paternal Obesity Be Promoting Pca Development In the Off...mentioning

confidence: 99%

Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact

Santos-Pereira,

Pereira,

Rebelo

et al. 2023

Nutrients

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In recent decades, the escalating prevalence of metabolic disorders, notably obesity and being overweight, has emerged as a pressing concern in public health. Projections for the future indicate a continual upward trajectory in obesity rates, primarily attributable to unhealthy dietary patterns and sedentary lifestyles. The ramifications of obesity extend beyond its visible manifestations, intricately weaving a web of hormonal dysregulation, chronic inflammation, and oxidative stress. This nexus of factors holds particular significance in the context of carcinogenesis, notably in the case of prostate cancer (PCa), which is a pervasive malignancy and a leading cause of mortality among men. A compelling hypothesis arises from the perspective of transgenerational inheritance, wherein genetic and epigenetic imprints associated with obesity may wield influence over the development of PCa. This review proposes a comprehensive exploration of the nuanced mechanisms through which obesity disrupts prostate homeostasis and serves as a catalyst for PCa initiation. Additionally, it delves into the intriguing interplay between the transgenerational transmission of both obesity-related traits and the predisposition to PCa. Drawing insights from a spectrum of sources, ranging from in vitro and animal model research to human studies, this review endeavors to discuss the intricate connections between obesity and PCa. However, the landscape remains partially obscured as the current state of knowledge unveils only fragments of the complex mechanisms linking these phenomena. As research advances, unraveling the associated factors and underlying mechanisms promises to unveil novel avenues for understanding and potentially mitigating the nexus between obesity and the development of PCa.

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Serum 17β-estradiol fails as a marker in identification of aggressive tumour disease in patients with localized prostate cancer

Abstract: Pretreatment serum 17β-estradiol (E2) cannot be considered as a suitable marker for aggressive tumour disease in patients with localized prostate cancer.

Cited by 4 publications

References 29 publications

Higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes

Higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes

Predictive Value of Hormonal Evaluation Before Prostate Needle Biopsy on Prostate Cancer T Stage and Prognosis

Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact

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