Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers

Kim, Hyunki; Chung, Hanshik; Lê, Hương Giang; Na, Byoung-Kuk; Cho, Min-Chul

doi:10.1371/journal.pone.0246541

Cited by 14 publications

(11 citation statements)

References 39 publications

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“…Simultaneously to dynamic increase of 25(OH)D 3 and 1,25(OH) 2 D 3 , we noted early triggering of catabolic pathway. We found that serum 24,25(OH) 2 D 3 concentration was positively correlated with serum 25(OH)D 3 , which is in accordance with the study published by Kim et al [44], in which strong correlation between 25(OH)D 3 and 24,25(OH) 2 D 3 was observed (r = 0.868, p < 0.001). This relationship may be explained by the fact that enzymatic synthesis of 24,25(OH) 2 D is regulated by 25(OH)D concentration and vitamin D receptor activity in CYP24A1 [44,45].…”

Section: Discussionsupporting

confidence: 92%

“…We found that serum 24,25(OH) 2 D 3 concentration was positively correlated with serum 25(OH)D 3 , which is in accordance with the study published by Kim et al [44], in which strong correlation between 25(OH)D 3 and 24,25(OH) 2 D 3 was observed (r = 0.868, p < 0.001). This relationship may be explained by the fact that enzymatic synthesis of 24,25(OH) 2 D is regulated by 25(OH)D concentration and vitamin D receptor activity in CYP24A1 [44,45]. CYP24A1 is also inducible by its substrate 1,25(OH) 2 D 3 , which is a protective mechanism from excess VDR pathway activation.…”

Section: Discussionsupporting

confidence: 92%

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The Effect of a Single High Dose of Vitamin D on Serum Levels of Its Metabolites in the Elderly

Leszczyńska¹,

Szatko²,

Kowalski³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Vitamin D is a dietary micronutrient responsible for calcium and phosphorus metabolism and multiple extraskeletal actions. The assessment of vitamin D status is commonly based on measurement of 25(OH)D total concentration in serum. However, the usage of LC-MS/MS technique allows to reliably assess a panel of vitamin D metabolites in serum or plasma, which may help to investigate the metabolic paths of vitamin D, especially in populations at risk of deficiency. Methods: A randomized, two-arms, open study was conducted on 58 patients (28 female and 30 male; aged from 61 to 96 years old). The primary aim was to assess the effects of a single, high, oral dose of vitamin D3 ( 120,000 IU) on serum 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, 3-epi-25(OH)D3, 1,25(OH)2D3, 24,25(OH)2D3/25(OH)D3 ratio, and 25(OH)D3/3-epi-25(OH)D3 ratio concentration (measured by LC-MS/MS) at baseline, 3 days and 7 days after administration, compared to control group. The secondary aim was assessment of influence of percentage of fat tissue on serum metabolites of vitamin D and their changes after bolus dose. Results: 56.6% study group attained a serum 25(OH)D3 concentration >30 ng/mL. All subjects, except for one patient achieved a serum 25(OH)D3 concentration >20 ng/mL after administration. No one exceed reference value of vitamin D (30-50 ng/mL). Among participants who received vitamin D3 there were significant increase in 25(OH)D3, 3-epi-25(OH)D3, 1,25(OH)2D3, 24,25(OH)2D3 on 3rd day after administration. 24,25(OH)2D3 concentration gradually grew, achieving the highest concentration on 7th day. The percentage increase of 25(OH)D3 was negatively correlated with baseline 25(OH)D3 (r = -0.688, p = 0.001). Positive correlation between percentage increase in 25(OH)D3 and a percentage increase serum concentration of 24,25(OH)2D3 (r = 0.954, p < 0.001), 3-epi-25(OH)D3 (r = 8.03, p < 0.001) and 1,25(OH)2D3 (r = 0.789, p < 0.001) were found. None of the study participants developed hypercalcemia. The baseline concentration of analyzed metabolites of vitamin D in serum and their percentage increase were neither dependent on BMI nor percentage of fat tissue. Conclusions: High dose of vitamin D rapidly increases 25(OH)D3 concentration in the elderly patients. The response to the bolus of vitamin D includes activation of 3-epimerase, followed by production of 24,25(OH)2D3, which protects from excessive increase of active form of vitamin D.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

The Effect of a Single High Dose of Vitamin D on Serum Levels of Its Metabolites in the Elderly

Leszczyńska¹,

Szatko²,

Kowalski³

et al. 2022

Front. Biosci. (Landmark Ed)

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“…However, only free (unbound) and albumin-bound vitamin D reflect biological activity; 44 in addition, the effects of vitamin D should be identified through vitamin D receptor polymorphisms. Nevertheless, a study involving an Asian sample reported that total 25(OH)D concentrations were closely correlated with bioavailable 25(OH)D. 45 Therefore, 25(OH)D can be regarded as a primary marker of vitamin D status. Sixth, peripheral NfL levels do not represent total NfL levels in the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder

Chen

Huang²,

Chiu³

et al. 2022

BJPsych open

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Background Bipolar disorder is a chronic mental disorder related to cognitive deficits. Low serum vitamin D levels are significantly associated with compromised cognition in neuropsychiatric disorders. Although patients with bipolar disorder frequently exhibit hypovitaminosis D, the association between vitamin D and cognition in bipolar disorder, and their neuroaxonal integrity, is unclear. Aims To investigate the interaction effects between vitamin D and neurofilament light chain (NfL) levels on cognitive domains in bipolar disorder. Method Serum vitamin D and NfL levels were determined in 100 euthymic patients with bipolar disorder in a cross-sectional study. Cognitive function was measured with the Brief Assessment of Cognition in Affective Disorders. We stratified by age groups and used general linear models to identify associations between vitamin D and NfL levels and their interaction effects on cognitive domains. Results The mean vitamin D and NfL levels were 16.46 ng/nL and 11.10 pg/mL, respectively; 72% of patients were vitamin D deficient. In the older group, more frequent hospital admissions and lower physical activity were identified in the group with versus without vitamin D deficiency. The age-modified interaction effect of vitamin D and NfL was associated with composite neurocognitive scores and verbal fluency in both age groups, and with processing speed domain in the younger group. Conclusions We observed a high vitamin D deficiency prevalence in bipolar disorder. We identified the interaction of vitamin D and NfL on cognitive domains, and the effect was modified by age. Longitudinal or randomised controlled studies enrolling patients with various illness durations and mood statuses are required to validate our findings.

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“…Vitamin D deficiency can accelerate and exacerbate osteopenia, osteoporosis, and fractures in adults ( 31 – 33 ). In Korea, vitamin D status is still deteriorating, and vitamin D deficiency is a fairly common health problem ( 34 , 35 ). In the susceptible population, cholecystectomy may play an important role in the risk of fracture.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea

et al. 2021

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ObjectivesTo evaluate the risk of fracture in individuals with a history of cholecystectomy in Korean population.MethodsIndividuals (n = 143,667) aged ≥ 40 y who underwent cholecystectomy between 2010 and 2015 and the controls (n = 255,522), matched by age and sex, were identified from the database of the Korean National Health Insurance Services. The adjusted hazard ratio (aHR) and 95% confidence interval (CI) of fracture were estimated following cholecystectomy, and a Cox regression analysis was performed.ResultsThe incidence rates of all fractures, vertebral, and hip fractures were 14.689, 6.483 and 1.228 cases per 1000 person-years respectively in the cholecystectomy group, whereas they were 13.862, 5.976, and 1.019 cases per 1000 person-years respectively in the control group. After adjustment for age, sex, income, place of residence, diabetes mellitus, hypertension, dyslipidemia, smoking, alcohol drinking, exercise, and body mass index, patients who underwent cholecystectomy showed an increased risk of all fractures, vertebral fractures, and hip fractures (aHR [95% CI]: 1.095 [1.059-1.132], 1.134 [1.078-1.193], and 1.283 [1.139-1.444] for all fractures, vertebral fractures, and hip fractures, respectively). The risk of vertebral fractures following cholecystectomy was more prominent in the young age group (40 to 49 y) than in the old age group (≥ 65 y) (1.366 [1.082-1.724] vs. 1.132 [1.063-1.206], respectively). However, the incidence of hip fractures following cholecystectomy was not affected by age.ConclusionIndividuals who underwent cholecystectomy have an increased risk of fracture. In the younger population, the risk of vertebral fractures may be further increased following cholecystectomy.

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Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers

Cited by 14 publications

References 39 publications

The Effect of a Single High Dose of Vitamin D on Serum Levels of Its Metabolites in the Elderly

The Effect of a Single High Dose of Vitamin D on Serum Levels of Its Metabolites in the Elderly

The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder

The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea

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