Serum 25-hydroxy vitamin D and exercise capacity in COPD

Ferrari, Marcello; Schenk, Kai; Papadopoulou, Christina; Ferrari, Pietro; Carbonare, Luca Dalle; Bertoldo, Francesco

doi:10.1136/thx.2010.152785

Cited by 22 publications

(22 citation statements)

References 4 publications

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“…Moreover, the TT genotype in GC of the DBP gene was shown to be associated with a 2-fold increase in risk for COPD. Another cohort analysis of 79 COPD patients demonstrated a positive correlation between 25(OH)D and exercise capacity 70 . Nonetheless, a RCT of 182 COPD patients receiving 100,000 IU cholecalciferol (or placebo) every 4 weeks over a period of one year did not show a global difference in rates of exacerbation, hospitalization, quality of life, or death 72 .…”

Section: Associations Between Vitamin D and Diseasementioning

confidence: 94%

Vitamin D and Major Chronic Illness

Quraishi

Camargo

2012

j restorat med

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OBJECTIVE To review the current literature regarding vitamin D insufficiency and supplementation in major illnesses. DESIGN AND METHODS We reviewed Pubmed-indexed, English language manuscripts from January, 2003 to June, 2012 using search terms related to vitamin D, all-cause mortality, cardiovascular disease, pulmonary disease, diabetes mellitus, and cancer. OUTCOME MEASURES Incidence of disease, risk ratios associated with 25-hydroxyvitamin D [25(OH)D] levels, and/or vitamin D supplementation schedules were documented. RESULTS Although 25(OH)D levels ≥20 ng/mL were often associated with improved health outcomes, evidence suggests that 25(OH)D levels ≥30 ng/mL may confer additional health benefits. CONCLUSIONS Based on the available evidence, vitamin D supplementation to restore 25(OH)D levels within a range of 30-50 ng/mL is reasonable in order to optimize potential benefits and minimize potential risks. This, of course, should be considered in the context of individual patient needs and co-morbidities.

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Section: Associations Between Vitamin D and Diseasementioning

confidence: 94%

Vitamin D and Major Chronic Illness

Quraishi

Camargo

2012

j restorat med

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“…In a study of 414 heavy smokers, 25(OH)D serum concentrations were strongly correlated with the severity of chronic obstructive pulmonary disease symptoms and FEV 1 (r=0.28, p<0.0001) . A similar study found a correlation between increased 25(OH)D levels and increased FEV 1 (r=0.504, p<0.001), maximal aerobic capacity (r=0.247, p<0.05), and transfer factor of the lung for carbon monoxide in a single breath (r=0.496, p<0.001) in 79 men with stable chronic obstructive pulmonary disease . The authors speculated that vitamin D supplementation might lead to improvements in exercise capacity due to its effects on muscle mass and function rather than addressing airflow limitations.…”

Section: Unproven Benefits Of Vitamin D Supplementationmentioning

confidence: 99%

Vitamin D Supplementation: What's Known, What to Do, and What's Needed

Haines

Park

2012

Pharmacotherapy

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The use of vitamin D supplements to prevent and treat a wide range of illnesses has increased substantially over the last decade. Epidemiologic evidence links vitamin D deficiency to autoimmune disease, cancer, cardiovascular disease, depression, dementia, infectious diseases, musculoskeletal decline, and more. The Institute of Medicine published an exhaustive report in 2010 that concluded that vitamin D supplementation for indications other than musculoskeletal health was not adequately supported by evidence and that most North Americans receive sufficient vitamin D from their diet and sun exposure. These conclusions are at odds with some clinical practice guidelines; thus, we sought to summarize the best available evidence regarding the benefits of vitamin D supplementation, to examine the potential risks, and to provide practical dosing advice. The adequacy of vitamin D stores is determined by measuring the 25-hydroxyvitamin D serum concentrations. The demarcations between deficiency (< 20 ng/ml), insufficiency (20-30 ng/ml), and optimal (30-80 ng/ml) serum concentrations are controversial. Vitamin D in doses of 800-5000 IU/day improve musculoskeletal health (e.g., reduces the rate of fractures and falls in older adults (aged ≥ 65 yrs). In patients with documented vitamin D deficiency, a cumulative dose of at least 600,000 IU administered over several weeks appears to be necessary to replenish vitamin D stores. Single large doses of 300,000-500,000 IU should be avoided. Vitamin D supplementation should not be offered routinely to other patient populations. Although results from some prospective clinical trials are promising, most have not been robustly designed and executed. The decision by young, otherwise healthy adults to take vitamin D in doses of 2000 IU/day or lower is unlikely to cause harm. For patients who are not at risk for developing vitamin D deficiency, sensible sun exposure is an inexpensive and enjoyable way to maintain vitamin D stores.

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“…Epidemiological studies have further suggested that vitamin D insufficiency is associated with poor lung function in susceptible populations, particularly in patients with asthma and chronic obstructive pulmonary disease (COPD; Gilbert et al, 2009; Chishimba et al, 2010; Forrest and Stuhldreher, 2011; Kunisaki et al, 2011) who are exposed to higher levels of air pollutants (airborne particulates). These susceptible individuals may develop frequent exacerbations, rapid decline in lung function, and exercise capacity (Ferrari et al, 2010; Janssens et al, 2010; Newnham et al, 2010; Hansdottir and Monick, 2011). …”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Susceptibility of Chronic Lung Diseases: Role of Epigenetics

Sundar¹,

Rahman²

2011

Front. Pharmacol.

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Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environmental agents (airborne particulates). Recent studies have highlighted the role of vitamin D and vitamin D receptor (VDR) in regulation of several genes that are involved in inflammation, immunity, cellular proliferation, differentiation, and apoptosis. Vitamin D has also been implicated in reversal of steroid resistance and airway remodeling, which are the hallmarks of chronic obstructive pulmonary disease (COPD) and severe asthma. VDR protein level is decreased in lungs of patients with COPD. VDR deficient mice develop an abnormal lung phenotype with characteristics of COPD, such as airspace enlargement and decline in lung function associated with increased lung inflammatory cellular influx, and immune-lymphoid aggregates formation. Dietary vitamin D may regulate epigenetic events, in particular on genes which are responsible for COPD susceptibility. Active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism. This review provides an update on the current knowledge and understanding on vitamin D, and susceptibility of chronic lung diseases in relation to the possible role of epigenetics in its molecular action. Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency.

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Serum 25-hydroxy vitamin D and exercise capacity in COPD

Cited by 22 publications

References 4 publications

Vitamin D and Major Chronic Illness

Vitamin D and Major Chronic Illness

Vitamin D Supplementation: What's Known, What to Do, and What's Needed

Vitamin D and Susceptibility of Chronic Lung Diseases: Role of Epigenetics

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