Serum 25-hydroxyvitamin D and parathyroid hormone in relation to plasma B-type natriuretic peptide: the Hoorn Study

Ballegooijen, Adriana J. van; Visser, Marjolein; Snijder, Marieke B.; Dekker, Joost; Nijpels, Giel; Stehouwer, Coen D.A.; Diamant, Michaëla; Brouwer, Ingeborg A.

doi:10.1530/ec-12-0033

Cited by 7 publications

(7 citation statements)

References 36 publications

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“…Vitamin D status was assessed by measuring serum 25OHD concentrations with a competitive binding protein assay (DiasSorin) (25). Plasma B-type natriuretic peptide (BNP), a sensitive marker of ventricular dysfunction, was determined using an immunoradiometric assay (Shionoria, Osaka, Japan) (27). We measured LV mass as an estimate of myocardial structure using echocardiography (21).…”

Section: Additional Measurements At Baselinementioning

confidence: 99%

Serum Parathyroid Hormone in Relation to All-Cause and Cardiovascular Mortality: The Hoorn Study

Ballegooijen

Reinders

Visser

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context: Higher PTH concentrations have been associated with fatal cardiovascular diseases (CVDs), but data in the general population are scarce.Objective: We investigated whether higher PTH concentrations are prospectively associated with all-cause and CVD mortality.Design, Setting, Participants: This study used data from the Hoorn Study, a prospective populationbased cohort with baseline measurements between 2000 and 2001. We included 633 participants, mean age 70.1 Ϯ 6.6 years, 51% female. Serum intact PTH was measured using a 2-site immunoassay. Main Outcome Measures:Outcomes were all-cause and CVD mortality based on clinical files and coded according to the International Classification of Diseases, ninth revision. We used KaplanMeier plots to estimate survival curves and Cox regression to estimate hazard ratios (HRs) using season-specific PTH quartiles.Results: During a median follow-up of 7.8 years, 112 participants died, of which 26 deaths (23%) were cardiovascular. Survival curves by PTH quartiles differed for all-cause mortality (log-rank P ϭ .054) and CVD mortality (log-rank P ϭ .022). In a multivariate model, the highest PTH quartile was associated with all-cause mortality; HR ϭ 1.98 (1.08, 3.64). Kidney function slightly attenuated the PTH risk association, but risk persisted; HR ϭ 1.93 (1.04, 3.58). The results for CVD mortality showed a similar pattern, although the association was significant only in a threshold model (quartile 4 vs quartile 1-3); HR ϭ 2.56 (1.11, 5.94). Conclusions:Among a general older population, higher PTH concentrations were associated with higher all-cause mortality risk, mostly explained by fatal CVD events. We suggest to evaluate whether individuals with high PTH concentrations benefit from therapeutic approaches targeted to decrease PTH concentrations. and novel factors (fibroblast growth factor23 [FGF23] and klotho). Individuals with excessive PTH concentrations that result from primary or secondary hyperparathyroidism have a higher risk of cardiovascular disease

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Section: Additional Measurements At Baselinementioning

confidence: 99%

Serum Parathyroid Hormone in Relation to All-Cause and Cardiovascular Mortality: The Hoorn Study

Ballegooijen

Reinders

Visser

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…16 Hypertension, prior CVD 15 and an estimate of kidney function-glomerular filtration rate-were calculated as previously described. 20 All participants, except those with previously diagnosed diabetes, underwent a standard 75 g oral glucose tolerance test to assess glucose status and were then classified into normal, impaired glucose metabolism or type 2 diabetes according to the 2006 World Health Organization criteria. 21 Participants filled out questionnaires to obtain information on medication use, smoking status, education level and physical activity.…”

Section: Additional Measurementsmentioning

confidence: 99%

Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study

et al. 2013

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“…Other prior studies generally have not found cross‐sectional associations of vitamin D with BNP or NT‐proBNP. In cross‐sectional analyses, 25(OH)D was not associated with BNP in the Hoorn study (older general population of white men and women), in a population of CHD patients, or in dialysis patients . In the Cardiovascular Health Study, 25(OH)D was inversely associated with NT‐proBNP in unadjusted analyses but not in analyses adjusted for demographic and CVD risk factors .…”

Section: Discussionmentioning

confidence: 91%

“…Whether low vitamin D levels are associated with subclinical myocardial damage and wall stress is not well established. Prior cross‐sectional studies have shown conflicting results . To our knowledge, however, there have been no prospective population‐based studies evaluating the association of low vitamin D with changes in levels of hs‐cTnT or NT‐proBNP.…”

Section: Introductionmentioning

confidence: 97%

“…Prior cross-sectional studies have shown conflicting results. [13][14][15][16][17] To our knowledge, however, there have been no prospective population-based studies evaluating the association of low vitamin D with changes in levels of hs-cTnT or NT-proBNP. It is unknown whether low 25(OH)D is associated with incident subclinical myocardial damage and wall stress and whether this association varies by age, sex, or race subgroups.…”

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confidence: 99%

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25‐Hydroxyvitamin D Levels and Markers of Subclinical Myocardial Damage and Wall Stress: The Atherosclerosis Risk in Communities Study

Michos

Selvin

Misialek

et al. 2016

JAHA

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BackgroundLow 25‐hydroxyvitamin D (25[OH]D) is associated with increased cardiovascular disease risk. Less known is whether 25(OH)D deficiency contributes to subclinical myocardial damage and wall stress (high‐sensitivity cardiac troponin T [hs‐cTnT] and N‐terminal pro–brain natriuretic peptide [NT‐proBNP]) or whether associations vary among subgroups.Methods and ResultsOverall, 11 311 Atherosclerosis Risk in Communities participants without prevalent cardiovascular disease had 25(OH)D, hs‐cTnT, and NT‐proBNP measured at baseline (1990–1992), and 8990 had measurements of hs‐cTnT and NT‐proBNP repeated 6 years later. We examined associations of deficient 25(OH)D (<20 ng/mL) with prevalent elevated hs‐cTnT (≥14 ng/L) and NT‐proBNP (≥100 pg/mL), change in hs‐cTnT and NT‐proBNP, and incident elevated hs‐cTnT and NT‐proBNP. We tested for interactions by age (<56 and ≥56 years), sex, and race. In fully adjusted models, 25(OH)D was not associated with prevalent elevated hs‐cTnT and NT‐proBNP. Deficient 25(OH)D, however, was associated with increased 6‐year change in hs‐cTnT (β=0.54 ng/L [95% CI 0.08–1.01]) but not change in NT‐proBNP. Deficiency in 25(OH)D was not associated with incident elevated hs‐cTnT in the overall cohort but was associated with incident elevated hs‐cTnT in younger but not older adults (relative risk 2.18 [95% CI 1.21–3.94] versus 0.78 [95% CI 0.56–1.08], respectively; P=0.01 for interaction by age). Deficient 25(OH)D was also associated with incident elevated NT‐proBNP in men but not women (P=0.01 for interaction by sex).ConclusionsVitamin D deficiency was associated with increased 6‐year change in hs‐cTnT levels. Hypothesis‐generating differences in associations by age and sex, but not race, were observed. If these associations are causal, further research is needed to understand mechanisms by which low 25(OH)D confers increased risk in these subgroups and whether treating deficient 25(OH)D can prevent myocardial damage and wall stress.

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Serum 25-hydroxyvitamin D and parathyroid hormone in relation to plasma B-type natriuretic peptide: the Hoorn Study

Cited by 7 publications

References 36 publications

Serum Parathyroid Hormone in Relation to All-Cause and Cardiovascular Mortality: The Hoorn Study

Serum Parathyroid Hormone in Relation to All-Cause and Cardiovascular Mortality: The Hoorn Study

Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study

25‐Hydroxyvitamin D Levels and Markers of Subclinical Myocardial Damage and Wall Stress: The Atherosclerosis Risk in Communities Study

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