Serum 25-hydroxyvitamin D and risk of breast cancer: results of a large population-based case–control study in Mexican women

Fedirko, Veronika; Torres-Mejı́a, Gabriela; Ortega-Olvera, Carolina; Biessy, Carine; Ángeles-Llerenas, Angélica; Lazcano‐Ponce, Eduardo; Saldaña-Quiroz, Vicente A.; Romieu, Isabelle

doi:10.1007/s10552-012-9984-z

Cited by 35 publications

(30 citation statements)

References 41 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current study is among the first, to our knowledge, to evaluate the association between serum 25(OH)D and breast cancer in women residing in Saudi Arabia, an area of high UV sunlight exposure, but potentially low vitamin D status related to skin type and cultural practices of dress. A study in Mexican women showed a 47% reduction in breast cancer risk in women with circulating concentrations of 25(OH)D .30 mg/mL (36). A study of women in the military did not show a significant relation between vitamin D status and breast cancer; however, among women sampled within 90 d of diagnosis, women in the lowest quintile had an OR of 3.3 for incident breast cancer (37) similar to our findings.…”

Section: Discussionsupporting

confidence: 83%

Vitamin D status and breast cancer in Saudi Arabian women: case-control study

Yousef¹,

Jacobs²,

Kang³

et al. 2013

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 83%

Vitamin D status and breast cancer in Saudi Arabian women: case-control study

Yousef¹,

Jacobs²,

Kang³

et al. 2013

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…Several observational studies and one RCT, suggest supplementation with vitamin D+calcium reduced cancer risk more than supplementation with vitamin D alone [24],[13],[25],[26]. Thus, to determine the effect of vitamin D alone, either the effect of calcium supplementation alone has to be determined if calcium supplementation is given solely to the treatment arm, as was the case in the later Lappe study [13], or both arms should receive calcium supplementation.…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trials of vitamin D and cancer incidence: A modeling study

Grant

Boucher

2017

PLoS ONE

View full text Add to dashboard Cite

Although geographic ecological studies and observational studies find that ultraviolet B exposure and 25-hydroxyvitamin D [25(OH)D] concentrations are inversely correlated with 15–20 types of cancer, few randomized controlled trials (RCTs) of vitamin D support those findings. The poor design of some RCTs may account for that lack of support. Most vitamin D RCTs to date have considered the vitamin D dose, rather than initial, final, or changes in, serum 25(OH)D concentrations. Here a model is developed for use in designing and analyzing vitamin D RCTs with application to cancer incidence. The input variables of the model are vitamin D dose, baseline and achieved 25(OH)D concentrations, known rates of cancer for the population, and numbers of participants for the treatment and placebo arms is estimated—vitamin D dosage and numbers of participants are varied to achieve desired hazard ratio significance, using information from two vitamin D RCTs on cancer incidence conducted in Nebraska with good agreement between the model estimates and reported hazard ratios. Further improvements to the conduct of vitamin D RCTs would be to start the trial with a moderate bolus dose to achieve the desired 25(OH)D concentrations, and bloodspot 25(OH)D assay use in summer and winter annually to monitor seasonal and long-term changes in 25(OH)D concentration and compliance, and to allow dosage adjustment for achievement of desired vitamin D status.

show abstract

“…Mexican women with serum vitamin D levels < 20 ng/ml (defined as cutoff value for deficiency) had a higher risk of BC than women with a level > 20 ng/ml. In addition, a significant inverse dose-response was observed at higher levels of vitamin D associated with lower risk of BC 55 . Similarly, higher serum levels of vitamin D (> 27.3 ng/ml) were significantly inversely associated with lower percent mammographic density among young Mexican women with BMI < 27 kg/m 2 (median value), suggesting that some groups of women may benefit from vitamin D supplementation 56 .…”

Section: Vitamin Dmentioning

confidence: 92%

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

Romieu

Amadou

Chajès

2017

RIC

View full text Add to dashboard Cite

The incidence of breast cancer (BC) is rising worldwide, with an increase in aggressive neoplasias in young women. Traditionally, BC in young women has been thought to be etiologically driven, primarily by genetic/hereditary factors. However, these factors explain only a small proportion of BCs, pointing to a role of the environment. Suspected factors responsible for this increase include lifestyle changes, notably alcohol consumption, diet with high intake of refined carbohydrates and saturated fat and low intake of polyunsaturated fatty acids (PUFA), fiber and vitamins (such as folate, vitamin D, and carotenoids), low physical activity, and body fatness, all of which may act from childhood and adolescent years through adulthood. Despite limited data on BC in young women, evidence points to the importance of a healthy lifestyle, including high intake of vegetables, fruits, legumes, fish, and poultry, low intake of sugar and fat, daily physical activity, low alcohol consumption, steady weight, and breastfeeding in preventing BC in young women. Preventive efforts should begin in early life to provide important benefits much later in life by shifting the long-term trajectory of risk accumulation. Data from Latin America and developing regions are still sparse. There is a need to harmonize studies in a global effort to fight the rise of BC incidence in low-and middle-income countries, where the nutritional transition is occurring rapidly. The stratification of BC by specific tumor characteristics needs to be considered since risk factors may be more particularly associated with the promotion of, or protection from, a defined type of BC.

show abstract

Serum 25-hydroxyvitamin D and risk of breast cancer: results of a large population-based case–control study in Mexican women

Abstract: The results of this large population-based case-control study indicate an inverse association between circulating vitamin D levels and breast cancer risk among pre- and postmenopausal Mexican women.

Cited by 35 publications

References 41 publications

Vitamin D status and breast cancer in Saudi Arabian women: case-control study

Vitamin D status and breast cancer in Saudi Arabian women: case-control study

Randomized controlled trials of vitamin D and cancer incidence: A modeling study

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

Contact Info

Product

Resources

About